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Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization:State-of-the-art in bone and associated tissue regeneration

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Bioactive Materials 2023年第10期28卷 284-310页

作者： Sayan Deb Dutta Tejal v.patil Keya Ganguly Aayushi Randhawa Ki-Taek Lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Republic of Korea Institute of Forest Science Kangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

关键词： Macrophage Immunomodulation Biomaterials 3D bioprinting Tissue engineering

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Mesenchymal stem cells,the secretome and biomaterials:Regenerative medicine application

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BIOCELL 2022年第10期46卷 2201-2208页

作者： KI-TAEK LIM TEJAL v.patil DINESH KPATEL SAYAN DEB DUTTA KEYA GANGULY AAYUSHI RANDHAWA Department of Biosystems Engineering Interdisciplinary Program in Smart AgricultureKangwon National UniversityChuncheon341Korea

Mesenchymal stem cells(MSCs)are multipotent cells usually isolated from bone marrow,endometrium,adipose tissues,skin,and dental *** played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material ***,MSCs have been widely explored for their application in regenerative medicine and COvID-19 *** approaches to evaluate the future of biomaterials and stem cell properties have been ***,misconceptions and ethical issues still exist,such as MSCs being non-angiogenic,anti-apoptotic,and immunoregulatory *** stem cells isolation primarily requires the consent of donors and can include the killing of fertilized *** issues generate questions related to ethical and moral ***,MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory *** are capable of secreting a broad range of biomolecules such as proteins,nucleic acids,exosomes,microRNAs,and membrane vesicles,collectively known as *** are released in response to the surrounding *** this article,we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.

关键词： Mesenchymal Stem Cells Secretome Biomaterials Regenerative Medicine

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Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration

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BIOCELL 2023年第4期47卷 789-808页

作者： AAYUSHI RANDHAWA SAYAN DEB DUTTA KEYA GANGULY TEJAL v.patil RACHMI LUTHFIKASARI KI-TAEK LIM Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Korea

Tissues are made up of cells and the extracellular matrix(ECM)which surrounds *** cells and tissues are actively adaptable to enduring significant stress that occurs in daily *** astonishing mechanical stress develops due to the interaction between the live cells and the non-living *** in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells,including growth,proliferation,and ***,the matrix’s characteristic features also impact the repair and regeneration of the damaged *** current study reviewed how the cell-ECM interaction regulates cellular behavior and physicochemical ***,we have described the response of cells to mechanical stresses,the importance of substrate stiffness and geometry in tissue regeneration,and the development of scaffolds to mimic the nature of native ECM in 3D for tissue engineering applications has also been ***,the study summarizes the conclusions and promising prospects based on the cell-ECM interplay.

关键词： ECM Stress Mechanical force Scaffold Mechanotransduction Tissue engineering

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Nanocellulose,a versatile platform:From the delivery of active molecules to tissue engineering applications

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Bioactive Materials 2022年第3期7卷 566-589页

作者： Tejal v.patil Dinesh K.Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra Ki-Taek Lim Department of Biosystems Engineering Institute of Forest ScienceKangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea Deptarment of Engineering Design Indian Institute of TechnologyMadras600036India

Nanocellulose,a biopolymer,has received wide attention from researchers owing to its superior physicochemical properties,such as high mechanical strength,low density,biodegradability,and *** can be extracted from wide range of sources,including plants,bacteria,and *** on the extraction process and dimensions(diameter and length),they are categorized into three main types:cellulose nanocrystals(CNCs),cellulose nanofibrils(CNFs),and bacterial nanocellulose(BNC).CNCs are a highly crystalline and needle-like structure,whereas CNFs have both amorphous and crystalline regions in their *** is the purest form of *** nanocellulose properties can be tuned by chemical functionalization,which increases its applicability in biomedical *** review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules,such as drugs,proteins,and ***-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and *** applications of nanocellulose and its composites in tissue engineering have been ***,the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

关键词： Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering

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Fully-inorganic strontium incorporated CsPbI_(2)Br perovskite solar cells with promoted efficiency and stability

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Journal of Energy Chemistry 2021年第11期30卷 451-458,I0010页

作者： Jyoti v.patil Sawanta S.Mali Chang Kook Hong Optoelectronic Convergence Research Center School of Advanced Chemical EngineeringChonnam National UniversityGwangju 61186South Korea Polymer Energy Materials Laboratory School of Advanced Chemical EngineeringChonnam National UniversityGwangju 61186South Korea

In the present investigation, we fabricated strontium (Sr2+) incorporated CsPbI2Br-based inorganic perovskite solar cells in ambient conditions. The morphology, crystallinity, absorption, elemental composition and photoluminescence analysis of the bare CsPbI2Br and CsPb1-xSrxI2Br perovskite thin films were studied systematically to investigate the role of Sr2+ incorporation. It is observed that the surface morphology of the CsPbI2Br perovskite thin film has been improved by partial substitution of Pb2+ by Sr2+ which facilitates photoactive black phase-stabilization and defect passivation. The champion device having CsPb0.98Sr0.02I2Br composition exhibited a power conversion efficiency (PCE) of 16.61% which is much higher than the bare device (13.65%). Furthermore, our CsPb0.98Sr0.02I2Br-based devices maintain > 85% of its initial efficiency over 100 h in ambient conditions.

关键词： All-inorganic perovskites Strontium incorporation Deposition method Phase stability Promoted efficiency

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Differently synthesized gold nanoparticles respond differently to functionalization with L-amino acids

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Particuology 2020年第5期18卷 97-104页

作者： Darshana v.Havaldar Reshma v.patil Disha N.Moholkar Priyanka S.Magdum Akash P.vadrale Kiran D.Pawar School of Nanoscience and Biotechnology Shivaji UniversityKolhapurMaharashtraIndia

The potential utility of gold nanoparticles(AuNPs)synthesized via different methods for biomedical applications vary greatly due to inherent differences in their surface *** the present study,we investigated the functionalization of AuNPs synthesized by chemical reduction,plant extract,and bacteria-mediated methods with 22 L-amino *** produced by bacteria-mediated(B_AuNPs)and plant-mediated(P_AuNPs)methods showed good potential,as they were able to be functionalized with six(histidine,lysine,methionine,phenylalanine,tryptophan,and tyrosine)and four(cystine,tryptophan,tyrosine,and valine)amino acids,*** contrast,AuNPs produced by chemical reduction(C_AuNPs)were not found to be suitable for *** functionalization conditions were found to be amino acid concentration of 20-25 mM and neutral pH(7)for P_AuNPs,whereas B_AuNPs tolerated more variable *** electrophoretic mobility of P_AuNPs after functionalization indicated that these nanoparticles were less sensitive than B_AuNPs to the deviations from optimal conditions.A significant change in mobility was observed when B_AuNPs were functionalized with either methionine or ***,the results of this study suggest that the suitability of the three differently synthesized AuNPs with amino acids is in the following order:B_AuNPs>P_AuNPs>C_AuNPs.

关键词： Gold nanoparticles Biogenic synthesis Amino acids Functionalization Electrophoretic mobility

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Effects of different levels of urea supplementation on nutrient intake and growth performance in growing camels fed roughage based complete pellet diets

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Animal Nutrition 2015年第4期1卷 356-361页

作者： Ntiranyibagira Emmanuel Niteen v.patil Shekbar R.Bhagwat Abdul Lateef Kang Xu Hongnan Liu Faculté d’Agronomie et de Bio-Ingénierie(FABI) Université du Burundi National Research Centre on Camel Indian Council for Agriculture Research College of veterinary Science & Animal Husbandry Sardarkrushinagar Dantiwada Agricultural University Department of Physiology and Biochemistry College of veterinary Science and Animal Husbandry Sardarkrushinagar Dantiwada Agricultural University Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences

The utilization of urea in camels has beneficial and negative effects. The aims of this study were to investigate the effects of different levels of urea supplementation on nutrients intake, digestibility,growth performance, feed efficiency and economics in growing camels fed roughage based complete pellet diets. In the present study, eighteen growing camels with an average live body weight of306.17 ± 2.05 kg were randomly assigned in three treatments: T1 = roughage complete pellet diet without urea,T2 = T1 plus 1% urea,and T3 = T1 plus 2% urea. The results showed that the urea supplementation significantly affected average daily feed and nutrient intake of dry matter(DM), organic matter(OM), crude protein(CP), neutral detergent fiber(NDF), and acid detergent fiber(ADF)(P verage daily intake of nitrogen free extract(NFE) and water were not influenced by increasing urea supplementation(P > 0.05). Similarly, digestion coefficient of DM, CP, ether extract(EE),crude fiber(CF) and ADF was influenced by increasing urea level(P vel(P > 0.05). The intake of digestive nutrients was similar among all treatment groups. Total body live weight gain and average daily gain were significantly higher in urea supplemented groups(P ved(P vely improve nutrients intake, digestibility, growth performance and feed conversion efficiency of growing camels.

关键词： Urea Nutrient intake Growth performance Complete pellet diet Feed conversion ratio

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Genetic Diversity and Population Structure in Landraces and Improved Rice varieties from India

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Rice science 2015年第3期22卷 99-107页

作者： Shailesh D.KUMBHAR Pawan L.KULWAL Jagannath v.patil Chandrakant D.SARAWATE Anil P.GAIKWAD Ashok S.JADHAv State Level Biotechnology Centre Mahatma Phule Agricultural University Agricultural Research Station Directorate of Sorghum Research

A set of 50 rice genotypes comprising landraces, local selections, and improved varieties were characterized using simple sequence repeat（SSR） and inter simple sequence repeat（ISSR） markers to study genetic diversity and population structure. Following unweighted pair group method with arithmetic mean based clustering using binary data of polymorphic markers, the genotypes were grouped into 5 clusters and 11 sub-clusters, whereas population structure analysis separated 50 rice genotypes into 5 sub-populations. Grouping of rice genotypes showed better resemblance with the pedigree information of the genotypes. Both genetic diversity and population structure analysis separated majority of the improved varieties from landraces and local selections. Some of the SSR markers amplified unique alleles which were specific to a particular genotype and could distinguish them from the rest. The results indicate that these rice genotypes exhibit a higher genetic diversity and can be very useful in rice improvement program.

关键词： rice genetic diversity molecular marker population structure simple sequence repeat

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清棉机打手速度对纱线性能的影响

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国际纺织导报 2015年第6期43卷 39-40,59页

作者： A.S.Bagwan P.Harshal v.patil 郝媛媛颜雪 Mukesh Patel技术管理与工程学院(印度) Priyadarshini Sahakari Soot Girni公司(印度) 不详

为优化ERM清棉机打手速度,将H4中级棉混合生产29.15 tex的纱线,研究了2种不同打手速度对纱线性能的影响,并利用乌斯特纱线条干均匀仪测试纱线性能,发现当打手速度从525 r/min增至650 r/min时,纱线Cv值、细节、粗节、棉结等有所减少,断... 详细信息

为优化ERM清棉机打手速度,将H4中级棉混合生产29.15 tex的纱线,研究了2种不同打手速度对纱线性能的影响,并利用乌斯特纱线条干均匀仪测试纱线性能,发现当打手速度从525 r/min增至650 r/min时,纱线Cv值、细节、粗节、棉结等有所减少,断裂强度有所增加。

关键词： ERM清棉机打手速度疵点断裂强度

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榕属植物提取物止泻作用的研究(英文)

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中西医结合学报 2012年第3期10卷 347-352页

作者： vikas v.patil Shandavi C.Bhangale Prashant J.Chaudhari Kundan P.Chaudhari Rajanikant T.Kakade vinod M.Thakare Chandrakant G.Bonde vijay R.patil Department of Pharmaceutical Chemistry Tapi Valley Education Society's Honorable Loksevak MadhukarraoChaudhari College of Pharmacy School of Pharmacy and Technology Management Narsee Monjee Institute of Management Studies University

目的:印度贾尔贡地区森林里的榕属植物多年来被当地人用来治疗腹泻。本研究根据当地人的用药传统选取3类榕属植物的特定部位来研究它们对不同大鼠腹泻模型的治疗及缓解作用。方法:不限性别地选取体质量在180~200 g的Wistar大鼠240只,在... 详细信息

目的:印度贾尔贡地区森林里的榕属植物多年来被当地人用来治疗腹泻。本研究根据当地人的用药传统选取3类榕属植物的特定部位来研究它们对不同大鼠腹泻模型的治疗及缓解作用。方法:不限性别地选取体质量在180~200 g的Wistar大鼠240只,在每个独立实验中,大鼠分别被分为8组,每组10只。通过蓖麻油诱导大鼠腹泻、大鼠胃肠蠕动测试及前列腺素E2诱导大鼠小肠淤积的3个独立实验来评估孟加拉榕树树皮、聚果榕树叶以及无花果叶的乙醇提取物治疗腹泻的作用。结果:孟加拉榕树树皮、聚果榕树叶和无花果叶的提取物具有显著抑制由蓖麻油诱发的大鼠腹泻及前列腺素诱导的大鼠小肠淤积的作用。当给予大鼠400、600 mg/kg的乙醇提取物时,腹泻显著减少。与标准对照药组对比,服用3种植物乙醇提取物的大鼠表现出显著的剂量依赖性腹泻缓解现象(P<0.01)。与蓖麻油诱导大鼠腹泻实验中的对照组相比,榕属植物的乙醇提取物被证实具有显著的降低粪便排泄量及排泄次数的作用(P<0.01)。所有的植物提取物具有显著减缓木炭餐在大鼠小肠内的推进速度并抑制由前列腺素E2引起的大鼠小肠淤积的作用。结论:印度贾尔贡地区的榕属植物具有止泻作用。这些植物的作用机制主要通过解痉和抗小肠淤积来缓解腹泻,这可能与榕属植物的乙醇提取物内含有鞣酸及类黄酮有关。

关键词：止泻药榕属植物皮植物叶植物提取物大鼠

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