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Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-bin Cai Xuan Wu Yin-bing tang Jin-Yan Wang Jun-Qin mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan Jie-Ni Xiong Wan-Xin Peng Jin-hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes:a retrospective cohort study of 12,218 fresh transfer cycles

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Reproductive and Developmental Medicine 2024年第3期8卷 151-161页

作者： mao Wang Li Tan Yu-bin Ding Xiao-Jun tang Tian Li Xin-Yue hu hu-Cen Zhong Qi Wan Zhao-hui Zhong Department of Epidemiology School of Public HealthResearch Center for Medicine and Social DevelopmentInnovation Center for Social Risk Governance in HealthChongqing Medical UniversityChongqing 400016China The Reproductive Center Chengdu Xinan Gynecology HospitalChengdu 610011China Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China School of Public HealthChongqing Medical UniversityChongqing 400016China Academician Workstation Department of PharmacologyChangsha Medical UniversityChangsha 410219China The Department of Reproductive Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Gynecology and Obstetrics West China Second HospitalSichuan UniversityChengdu 610041China

Objective:To investigate the potential relationships among the ovarian response prediction index(ORPI),follicle-oocyte index(FOI),and clinical pregnancy rate(CPR)in women undergoing their first in vitro fertilization/intracytoplasmic sperm injectionembryo transfer(IVF/ICSI-ET)fresh cycle ***:In this retrospective cohort study,we included 12,218 women who underwent their first IVF/ICSI-ET cycle between December 2014 and January *** primary and secondary outcomes of our study were CPR and cumulative live birth rate(CLBR),*** data were divided into three groups according to the ORPI and FOI *** logistic regression analyses,stratification analyses,interaction,restricted cubic splines,and receiver operating characteristic(ROC)curves were constructed to identify the relationships among ORPI,FOI,and ***:A statistically significant increase in CPR was detected from the lowest to the highest tertile group(ORPI:48.12%,54.07%,and 53.47%,P<0.001;FOI:49.99%,52.95%,and 52.71%,P=0.012).A higher CLBR was observed in the high group(ORPI:38.63%,44.62%,and 44.19%,P<0.001;FOI:41.02%,43.78%,and 42.59%,P=0.039).Multivariate logistic regression analysis revealed no statistically significant differences between ORPI,FOI,and neither CPR(odds ratio[OR][95%confidence interval{CI}],0.99[0.97–1.00]vs.[1.02{0.84–1.24}])nor CLBR(OR[95%CI],0.99[0.97–1.01]vs.0.99[0.81–1.20]).No significant association was found among FOI,ORPI,and CPR,even in the *** cubic spline analyses indicated the existence of a non-linear relationship across the entire range of FOI and *** ORPI and FOI variables had poor predictive ability(AUC<0.60)for ***:Both ORPI and FOI are not reliable predictors of clinical pregnancy or live birth outcomes in fresh *** and researchers should avoid using FOI and ORPI to assess pregnancy outcomes after fresh ET because of their limited relevance and predictive value.

关键词： In vitro fertilization Controlled ovarian hyperstimulation Ovarian response indexes Ovarian response prediction index Follicle-oocyte index Clinical pregnancy

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu Tao Li Ze‑bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu Han‑Xiong huang Wei‑hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Guang‑Yuan Luan bin‑bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑Da tang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da tang Yong-Hao Chen Jing-Yu tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-bin Liu Guang-Yuan Luan Chang-Jun Ning bin-bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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日本脑炎病毒免疫逃逸分子机制研究进展

畜牧兽医学报 2024年第6期55卷 2368-2378页

作者：何松汤德元曾智勇王彬黄涛毛茵茗周飘廖正波陈旭袁盛林胡雯雯周敏贵州大学动物科学学院贵阳550025

日本脑炎(Japanese encephalitis, JE)是由日本脑炎病毒(Japanese encephalitis virus, JEV)引起的一种蚊媒性人兽共患传染病,虽然已有商品化疫苗,但疫苗的预防具有一定的局限性且至今尚无有效药物治疗,一旦暴发将威胁人们的生命健康和... 详细信息

日本脑炎(Japanese encephalitis, JE)是由日本脑炎病毒(Japanese encephalitis virus, JEV)引起的一种蚊媒性人兽共患传染病,虽然已有商品化疫苗,但疫苗的预防具有一定的局限性且至今尚无有效药物治疗,一旦暴发将威胁人们的生命健康和公共安全,造成重大经济损失。JEV含有数量众多具有免疫逃逸功能的编码蛋白,这些蛋白逃逸宿主免疫功能的机制多样且复杂,但其机制仍不完全清楚。同时,JEV复杂的免疫逃逸机制可能是阻碍疫苗免疫保护效果的关键因素。因此,本文主要对JEV通过抑制干扰素反应,调节细胞凋亡、焦亡、自噬及宿主miRNA等多种途径逃逸机体先天免疫和适应性免疫机制进行概述,以期为JEV致病机理的研究和疫苗研发提供思路与理论基础。

关键词：日本脑炎病毒免疫逃逸天然免疫适应性免疫

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang Jing‑Yu tang Xiang‑Biao Qiu Zhen Chen mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu Han‑Xiong huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene

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Journal of Integrative Agriculture 2019年第8期18卷 1924-1935页

作者： WENG Bo RAN mao-liang CAo Rong PENG Fu-zhi LUo hui GAo hu tang Xiang-wei YANG An-qi CHEN bin College of Animal Science and Technology/hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal Hunan Agricultural University

MicroRNAs(miRNAs) have been widely identified in porcine testicular tissues and implicated as crucial regulators of proliferation, apoptosis, and differentiation in porcine spermatogenesis related cells. However, the function roles of most of the miRNAs that have been identified in Sertoli cells are poorly understood. In the present study, six experiments were conducted to study the regulatory role of miR-10b in porcine immature Sertoli cells. In experiment 1, the results showed that the relative mRNA expression level of miR-10b in porcine testicular tissues decreased quadratically(P0.05) on porcine immature Sertoli cell apoptosis. In experiment 6, the co-transfection treatment results showed that miR-10b promoted(P<0.05) porcine immature Sertoli cell proliferation by targeting DAZAP1 gene. Overall, these experiments demonstrated that miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene.

关键词： miR-10b DAZAP1 gene expression proliferation porcine immature Sertoli cell

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猪日本乙型脑炎病毒新型检测方法研究进展

中国兽医科学 2024年第2期54卷 240-247页

作者：何松汤德元曾智勇王彬黄涛毛茵茗周飘廖正波陈旭袁盛林胡雯雯周敏贵州大学动物科学学院贵州贵阳550025

日本乙型脑炎病毒(Japanese encephalitis virus,JEV)是人兽共患病日本乙型脑炎的病原,对世界养猪业造成了巨大的经济损失。因此,建立快速可靠的JEV检测方法,有利于及时检测JEV和采取措施防控日本乙型脑炎。本文总结了近年来检测JEV的... 详细信息

日本乙型脑炎病毒(Japanese encephalitis virus,JEV)是人兽共患病日本乙型脑炎的病原,对世界养猪业造成了巨大的经济损失。因此,建立快速可靠的JEV检测方法,有利于及时检测JEV和采取措施防控日本乙型脑炎。本文总结了近年来检测JEV的新型方法,包括分子生物学检测、免疫学检测、生物传感器检测等技术,以期为有效诊断及防治JEV感染提供技术指导。

关键词：猪日本乙型脑炎日本乙型脑炎病毒检测

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基于进化计算的DHMM训练方法

数据采集与处理 2002年第2期17卷 167-170页

作者：茅晓泉胡光锐唐斌上海交通大学电子工程系上海200030

隐马尔柯夫模型 (HMM)的传统训练方法—— Baum-Welch算法只能得到一个局部最优模型 ,从而影响最终的识别率。对于 CHMM,分段 K平均方法来取得一个初始值可以解决这一问题 ,但对 DHMM却改进不大。而基于全局搜索的进化计算的一个重要特... 详细信息

隐马尔柯夫模型 (HMM)的传统训练方法—— Baum-Welch算法只能得到一个局部最优模型 ,从而影响最终的识别率。对于 CHMM,分段 K平均方法来取得一个初始值可以解决这一问题 ,但对 DHMM却改进不大。而基于全局搜索的进化计算的一个重要特点便是可以得到次优解乃至全局最优解。本文把进化计算引入到DHMM的训练中去 ,提出一种改进的进化训练方法 ,实验结果表明 ,这种训练方法初具了全局搜索和快速收敛的特点 ,得到的模型优于传统方法和直接用进化计算所得的模型 ,提高了系统的识别率。

关键词：隐马尔柯夫模型语音识别语音信号处理进化计算 DHMM训练方法