Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients
作者机构:Pediatric Cancer Research CenterNational Clinical Research Center for Child HealthHangzhouChina Department of Surgical OncologyChildren's HospitalZhejiang University School of MedicineHangzhouChina Cancer CenterZhejiang UniversityNo.3333 Binsheng RodeHangzhouChina
出 版 物:《World Journal of Pediatrics》 (世界儿科杂志(英文版))
年 卷 期:2024年第20卷第3期
页 面:250-258页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:supported by General Program of National Natural Science Foundation of China(No.32270853) Key Program of Natural Science Foundation of Zhejiang Province(No.HDMZ23H160029)
主 题:Complication Neuroblastoma Risk factors Surgery
摘 要:Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.