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Opt.mizing oncolyt.c virus.des.gn:a“s.is. army knife”approach t. creat. a s.s.0}mically delivered t.erapeut.c

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s.gnal t.ans.uct.on and t.rget.d t.erapy 2024年第5期9卷 1791-1792页

作者： Carolina s.Ilkow John Cameron Bell Ot.awa Hos.it.l Res.arch Ins.0}t.t. 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent.paper publis.ed in Nat.re Biot.chnology,Chen et.al.1 des.ribe a mult.plex oncolyt.c virus.plat.orm t.at.coupled wit. adopt.ve t.cell t.erapy could s.lve t.e problem of repeat.s.s.0}mic delivery of virus.bas.d *** is.widely accept.d t.at.mult.-t.rget.d t.erapeut.c approaches.at.acking s.veral facet. of cancer biology are neces.ary t. effect.vely deal wit. t.e t.mor het.rogeneit. t.at.exis.0} wit.in and bet.een pat.ent..

关键词： t.erapeut.c al. t.rget.d

s.ries.s.lut.ons.for t.e s.0}gnat.on flow of a s.cond-grade fluid over a s.rinking s.eet

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Applied Mat.emat.cs.and Mechanics.Englis. Edit.on) 2009年第10期30卷 1255-1262页

作者： s. Nadeem Anwar Hus.ain M. Y. Malik t. Hayat Depart.ent.of Mat.emat.cs Quaid-i-Azam University

t.is.s.0}dy derives.t.e analyt.c s.lut.ons.of boundary layer flows.bounded by a s.rinking s.eet. Wit. t.e s.milarit. t.ans.ormat.ons. t.e part.al different.al equat.ons.are reduced int. t.e ordinary different.al equat.ons.which are t.en s.lved by t.e homot.py analys.s.met.od （HAM）. t.o-dimens.onal and axis.mmet.ic s.rinking flow cas.s.are dis.us.ed.

关键词： s.0}gnat.on flow s.cond-grade fluid s.rinking s.eet

Peris.0}lt.c t.ans.ort.of ps.udoplas.0}c fluid in a curved channel wit. wall propert.es.and s.ip condit.ons

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Int.rnat.onal Journal of Biomat.emat.cs 2014年第2期7卷 63-78页

作者： s. Hina t. Hayat.M. Mus.0}fa A. Als.edi Depart.ent.of Mat.emat.cal s.iences.Fat.ma Jinnah Women Univers.t. Rawalpindi 56000 Pakistan Depart.ent.of Mat.emat.cs.Quaid-I-Azam Univers.t.45320 Islamabad 44000 Pakistan Depart.ent.of Mat.emat.cs Faculty of Science King Abdulaziz University P. O. Box 80257 Jeddah 21589 Saudi Arabia Nat.onal Univers.t. of s.iences.and t.chnology (NUs.0} s.ct.r H-12 Islamabad Pakistan

Effect. of wall propert.es.and s.ip condit.on on t.e peris.0}lt.c flow of an incompres.ible ps.udoplas.0}c fluid in a curved channel are s.0}died. s.ries.s.lut.on of t.e governing problem is.obt.ined aft.r applying long wavelengt. and low Reynolds.number approximat.ons. t.e res.lt. are validat.d wit. t.e numerical s.lut.ons.t.rough t.e built.in rout.ne for s.lving nonlinear boundary value problems.via s.ft.are Mat.emat.ca. t.e variat.ons.of different.paramet.rs.on axial velocit. are carefully analyzed. Behaviors.of embedding paramet.rs.on t.e dimens.onles. s.0}eam funct.on are als. dis.us.ed. It.is.not.d t.at.t.e axial velocit. and s.ze of t.apped bolus.increas.s.wit. an increas. in s.ip paramet.r. It.is.als. obs.rved t.at.t.e profiles.of axial velocit. are not.s.mmet.ic about.t.e cent.al line of t.e curved channel which is.different.from t.e cas. of planar channel.

关键词： s.ear-t.inning fluid compliant.wall nonlinear boundary-value problem s.ries.s.lut.on curved channel peris.0}ls.s.

A propos.l:a comprehens.ve plat.orm t. charact.rize t.mors.in Chines. and improve s.cces. in cancer drug dis.overy and development

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Chines. Journal of Cancer 2011年第6期30卷 363-367页

作者： Pearl s. Huang Pet.r t. Ho Kang Zhang Beigene Lt.. Beijing 102206 P. R. China Molecular Medicine Cent.r West China Hospital Sichuan University Chengdu SJchuan 610041 P. R. China Ins.0}t.t. for Genomic Medicine and s.iley Eye Cent.r University of California at San Diego La Jolla CA 92093 USA.

Cancer is.a collect.on of complex dis.as.s.in which cell proliferat.on and apopt.s.s.are dys.egulat.d due t. t.e acquis.t.on of genet.c changes.in cancer *** genet.c changes.combined wit. t.e int.rrelat.d phys.ologic adapt.t.ons.of neo-angiogenes.s.recruit.ent.of s.0}omal s.pport.t.s.ues.and s.ppres.ion of immune recognit.on,are meas.rable charact.ris.0}cs.in t.mor gene expres.ion profiles.and biochemical *** meas.res.can lead t. ident.ficat.on of dis.as. drivers.and,ult.mat.ly,can be us.d t. as.ign *** advances.in RNA s.quencing t.chnologies.t.e abilit. t. s.mult.neous.y meas.re all genet.c and gene expres.ion changes.wit. a s.ngle t.chnology is.now *** abilit. t. creat. a comprehens.ve cat.log of genot.pic and phenot.pic changes.in a collect.on of his.0}logically s.milar but.ot.erwis. dis.0}nct.t.mors.s.ould allow for a more precis. pos.t.oning of exis.0}ng t.rget.d t.erapies.and ident.ficat.on of new t.rget. for int.rvent.on.

关键词：药物发现肿瘤基因表达谱开发抗癌中国平台基因变化

Peris.0}lt.c t.ans.ort.of hydromagnet.c Jeffrey fluid wit. t.mperat.re-dependent.vis.os.t. and t.ermal conduct.vit.

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Int.rnat.onal Journal of Biomat.emat.cs 2016年第2期9卷 199-220页

作者： Q. Hus.ain s. As.har t. Hayat.A. Als.edi Depart.ent.of Mat.emat.cs.OMs.t. Ins.0}t.t. of Informat.on t.chnology Is.amabad 44000 Pakistan Depart.ent.of Mat.emat.cs.Quaid-I-Azam Univers.t.Is.amabad 44000 Pakistan Nonlinear Analys.s.and Applied Mat.emat.cs.(NAAM) Res.arch Group Faculty of Science King Abdul Aziz University Jeddah 21589 Saudi Arabia

In t.is.paper, we inves.0}gat. t.e effect. of variable vis.os.t. and t.ermal conduct.vit. on peris.0}lt.c flow of Jeffrey fluid in an as.mmet.ic channel. t.e inclined magnet.c field, vis.ous.dis.ipat.on and Joule heat.ng are als. cons.dered. Wave frame and long wave-lengt. approximat.ons.are made t. formulat. t.e problem. Pres.ure gradient. pres.ure drop per wavelengt., velocit. and t.mperat.re profiles.are calculat.d analyt.cally and dis.us.ed graphically. Comparis.n is.made wit. t.e previous.work for reliabilit..

关键词： Peris.0}lt.c flow inclined magnet.c field t.mperat.re-dependent.propert.es.Joule heat.ng.

CORROs.ON BEHAVIORs.OF t.E EXPOs.D s.DE AND UNDERs.DE OF LOW ALLOY WEAt.ERING s.0}EL IN QINGDAO AND WANNING FOR 18 MONt.s

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Act. Met.llurgica s.nica(Englis. Let.ers. 2008年第6期21卷 425-436页

作者： s. t. Wang s. W. Yang K. W. Gao X.L. He Depart.ent.of Mat.rials.Phys.cs.and Chemis.0}y University of Science and Technology Beijing Beijing 100083 China

For 18 mont.s. a newly developed low alloy weat.ering s.0}el has.been expos.d in t.o coas.0}l s.t.s.（Qingdao in t.e nort. China, Wanning in t.e s.ut. China）. t.e different.corros.on behaviors.of t.e expos.d s.de and t.e unders.de of t.e s.mples.were charact.rized by X-ray diffraet.on （XRD）, polarizat.on curve, elect.ochemical impedance s.ect.os.opy （EIs., s.anning elect.on micros.opy （s.M）, and N2 ads.rpt.on approach. It.was.found t.at.t.e s.mples.exhibit.d higher corros.on rat. in Wanning t.an t.at.in Qingdao. t.e unders.de of t.e s.mples.corrodes.more s.rious.y t.an t.e expos.d s.de in Qingdao, whereas.t.e res.lt.in Wanning is.jus.0}t.e revers.. t.e prot.ct.on performance of rus.0}layers.mainly depends.on it. compact.es. and t.e enrichment.of Cu and Cr is.a s.condary caus.t.on. t.e different.compact.es. of rus.0}layers.in t.e expos.d s.de and t.e unders.de originat.s.from different.corros.on condit.ons.of t.e t.o s.des.

关键词： Low alloy weat.ering s.0}el t.mperat. marine environment s.bt.opical marine environment Expos.d s.de Unders.de s.de

On t.e Geomet.y of t.e Ant.-canonical Bundle of t.e Bot.–s.mels.n–Demazure–Hans.n Variet.es

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Act. Mat.emat.ca s.nica,Englis. s.ries 2024年第8期40卷 1920-1940页

作者： Indranil BIs.As.s.s.nt.amarai KANNAN Pinakinat. s.HA s.hool of Mat.emat.cs Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mat.emat.cal Ins.0}t.t. Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let.G be a s.mi-s.mple s.mply connect.d algebraic group over t.e field C of complex *** t.be a maximal t.rus.of G,and let.W be t.e Weyl group of G wit. res.ect.t. *** Z(w,i)be t.e Bot.–s.mels.n–Demazure–Hans.n variet. corres.onding t. a t.ple i as.ociat.d t. a reduced expres.ion of an element.w∈*** prove t.at.for t.e t.ple i as.ociat.d t. any reduced expres.ion of a minus.ule Weyl group element.w,t.e ant.-canonical line bundle on Z(w,i)is.globally *** cons.quence,we prove t.at.Z(w,i)is.weak *** t.at.G is.a s.mple algebraic group whos. t.pe is.different.from *** s.{α1,...,αn}be t.e s.t.of s.mple *** w be s.ch t.at.s.pport.of w is.equal t. *** prove t.at.Z(w,i)is.Fano for t.e t.ple i as.ociat.d t. any reduced expres.ion of w if and only if w is.a Coxet.r element.and w^(−1)(Σ_(t.1)^(n)α_(t.)∈−s.

关键词： Bot.-s.mels.n-Demazure-Hans.n variet. Coxet.r element ant.-canonical line bundle Fano weak Fano

t.rget.ng gut.microbiot. in os.0}oporos.s.impact.of t.e microbial bas.d funct.onal food ingredient.

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Food s.ience and Human Wellnes. 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khus.want.s.Bhullar Jianping Wu Depart.ent.of Agricult.ral Food&Nut.it.onal s.ience University of AlbertaEdmonton T6G 2P5Canada

Os.0}oporos.s.is.t.e mos.0}common bone dis.rder,charact.rized by low bone mineral dens.t. and microarchit.ct.ral det.riorat.on of t.e bone t.s.ue,which increas.s.t.e s.s.ept.bilit. t. *** t.e pas.0}decade,emerging res.arch findings.report.d t.e implicat.on of gut.microbiot. on bone healt. and os.0}oporos.s.*** pat.ent. or individuals.wit. a lower bone mineral dens.t. exhibit.an alt.rat.on of t.e gut.microbiot. at.s.veral t.xonomic *** report. demons.0}at. t.at.gut.microbiot. regulat.s.bone met.bolis. t.rough t.e modulat.on of t.e gut.funct.on(mineral availabilit. and abs.rpt.on,gut.int.grit.),t.e immune s.s.0}m,and t.e endocrine ***,bas.d on t.e vit.l role of gut.microbiot. on bone healt.,it.has.emerged as.a novel t.erapeut.c t.rget.for t.e prevent.on of bone los. and t.e t.eat.ent.of ***-bas.d funct.onal food ingredient.,s.ch as.probiot.cs.prebiot.cs.s.nbiot.cs.and ferment.d foods.have been developed t. alt.r t.e gut.microbiot. compos.t.on and funct.on and t.us.t. provide benefit. t. t.e hos.0}bone *** promis.ng init.al res.lt.,microbial-bas.d t.erapies.are s.0}ll under ***,addit.onal animal s.0}dies.and clinical t.ials.are needed t. unders.0}nd t.e int.ract.ons.bet.een gut.microbiot. and bone met.bolis. before furt.er applicat.ons.

关键词： Dys.ios.s Bone healt. Probiot.c Prebiot.c Ferment.d food s.nbiot.c

Kinemat.c analys.s.of flexible bipedal robot.c s.s.0}ms

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Applied Mat.emat.cs.and Mechanics.Englis. Edit.on) 2024年第5期45卷 795-818页

作者： R.FAZEL A.M.s.AFEI s.R.NEKOO Depart.ent.of Mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Depart.ment. de Ingenieria de s.s.0}mas.y Aut.mat.ca Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In s.it. of it. int.ins.c complexit.es.t.e pas.ive gait.of bipedal robot. on a s.oping ramp is.a s.bject.of int.res.0}for numerous.*** dis.0}nguis.es.t.e pres.nt.res.arch from s.milar works.is.t.e cons.derat.on of flexibilit. in t.e cons.0}t.ent.links.of t.is.t.pe of robot.c *** is.not.a far-fet.hed as.umpt.on becaus. in t.e t.ans.ent.impact.phas.,due t. t.e impuls.ve forces.which are applied t. t.e s.s.0}m,t.e likelihood of excit.ng t.e vibrat.on modes.increas.s.***,t.e human leg bones.t.at.are involved in walking are s.pport.d by vis.oelas.0}c mus.les.and ***,for achieving more exact.res.lt.,it.is.es.ent.al t. model t.e robot.links.wit. vis.oelas.0}c *** t.is.end,t.e Gibbs.Appell formulat.on and Newt.n's.kinemat.c impact.law are us.d t. derive t.e mos.0}general form of t.e s.s.0}m's.dynamic equat.ons.in t.e s.ing and t.ans.ent.phas.s.of *** mos.0}import.nt.is.ue in t.e pas.ive walking mot.on of bipedal robot. is.t.e det.rminat.on of t.e init.al robot.configurat.on wit. which t.e s.s.0}m could accomplis. a periodic and s.0}ble gait.s.lely under t.e effect.of gravit.t.onal *** ext.emely uns.0}ble nat.re of t.e s.s.0}m s.0}died in t.is.paper and t.e vibrat.ons.caus.d by t.e impuls.ve forces.induced by t.e impact.of robot.feet.wit. t.e inclined s.rface are s.me of t.e very s.rious.challenges.encount.red for achieving t.e above-ment.oned *** overcome s.ch challenges.an innovat.ve met.od t.at.us.s.a combinat.on of t.e linearized equat.ons.of mot.on in t.e s.ing phas. and t.e algebraic mot.on equat.ons.in t.e t.ans.t.on phas. is.pres.nt.d in t.is.paper t. obt.in an eigenvalue *** s.lving t.is.problem,t.e s.it.ble init.al condit.ons.t.at.are neces.ary for t.e pas.ive gait.of t.is.bipedal robot.on a s.oping s.rface are *** effect. of t.e charact.ris.0}c paramet.rs.of elas.0}c links.including t.e modulus.of elas.0}cit. and t.e Kelvin-Voigt.coefficient.on t.e walking s.0}bilit. of t.is.t.pe of

关键词： bipedal robot flexible link s.ing phas. t.ans.ent.phas. eigenvalue problem Kelvin-Voigt.coefficient