Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic

作     者：Carolina S.Ilkow John Cameron Bell Carolina S.Ilkow;John Cameron Bell

作者机构：Ottawa Hospital Research Institute501 Smyth RoadOttawaONK1H 8L6Canada 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第5期

页      面：1791-1792页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：C.S.I.and J.C.B.are supported by the Canadian Cancer Society Research Institute(CCSRI)and the Canadian Institutes of Health Research(CIHR) 

主　　题：therapeutic al. targeted 

摘      要：In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.