A proposal:a comprehensive platform to characterize tumors in Chinese and improve success in cancer drug discovery and development

作     者：Pearl S. Huang Peter T. Ho Kang Zhang 

作者机构：Beigene Ltd. Beijing 102206 P. R. China Molecular Medicine Center West China Hospital Sichuan University Chengdu SJchuan 610041 P. R. China Institute for Genomic Medicine and Shiley Eye Center University of California at San Diego La Jolla CA 92093 USA. 

出 版 物：《Chinese Journal of Cancer》 (CHINESE JOURNAL OF CANCER)

年 卷 期：2011年第30卷第6期

页      面：363-367页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：药物发现 肿瘤 基因表达谱 开发 抗癌 中国 平台 基因变化 

摘      要：Cancer is a collection of complex diseases in which cell proliferation and apoptosis are dysregulated due to the acquisition of genetic changes in cancer *** genetic changes,combined with the interrelated physiologic adaptations of neo-angiogenesis,recruitment of stromal support tissues,and suppression of immune recognition,are measurable characteristics in tumor gene expression profiles and biochemical *** measures can lead to identification of disease drivers and,ultimately,can be used to assign *** advances in RNA sequencing technologies,the ability to simultaneously measure all genetic and gene expression changes with a single technology is now *** ability to create a comprehensive catalog of genotypic and phenotypic changes in a collection of histologically similar but otherwise distinct tumors should allow for a more precise positioning of existing targeted therapies and identification of new targets for intervention.