Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

作     者：Pauline Duffuler Khushwant S.Bhullar Jianping Wu Pauline Duffuler;Khushwant S.Bhullar;Jianping Wu

作者机构：Department of Agricultural Food&Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第1期

页      面：1-15页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

主　　题：Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic 

摘      要：Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.