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Beyond reproduction：the role of progesterone in neuropathic pain after spinal cord injury

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Neural Regeneration Research 2016年第8期11卷 1238-1240页

作者： susana laura gonzález María Florencia Coronel Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquimica Humana Buenos Aires Argentina Laboratorio de Nocicepcion y Dolor Neuropatico Instituto de Biologia y Medicina Experimental CONICET Buenos Aires Argentina

Neuropathic pain,a type of pain arising after direct damage or disease of the nervous system,is often intractable and challenges the search of effective therapeutic *** particular,neuropathic pain is a very frequent s... 详细信息

关键词： progesterone intractable Beyond contributor reproduction neuronal NMDAR glial synaptic targeting

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.Garcia-Lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel Garcia-Hidalgo susana Gomez-gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio Garcia-gonzalez laura Lozano-Lopez Paula Garcia-gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

Classical and Non-Classical Celiac Disease Comparison: Ten Years of Study

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Open Journal of Pediatrics 2022年第2期12卷 309-319页

作者： Katia Regina Pena Schesquini-Roriz Jocelyn Cristina Betancourt Castellanos laura Martinez Martinez Gloria Maria Fraga Rodriguez susana Boronat Guerrero Isabel Badell Serra Department of Pediatrics Hospital de La Santa Creu I Sant Pau Universitat Autònoma de Barcelona Barcelona Spain Department of Medicine Federal University of Rond&ocirc nia Porto Velho Brazil

Objective: Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten. It has a variable combination of clinical manifestations and changes that have been occurring in recent decades however they are not known in detail. The purpose of the article is to compare Classical and Non-Classical CD cases in terms of demographic characteristics, duodenal biopsy, extraintestinal manifestations, and associated comorbidities. Materials and Methods: A comparative retrospective cohort study from January 2008 to December 2018. Results: A total of 128 cases were included: 84 Classical (66%) and 44 Non-Classical CD (34%). The family history of CD was identified in 14% of cases without differences between groups. The age at diagnosis was distinct for Classical and Non-Classical CD (4.9 ± 4 and 8.3 ± 4 years old;p 0.001), respectively. Important changes were found within the classical presentation, including mono symptoms and a significantly higher rate of intestinal atrophy;p = 0.04. The main Non-Classical CD symptom was recurrent abdominal pain. The extraintestinal manifestations (EIM) were identified in 42% and occurred in both groups. The comparison between groups showed differences in rates of migraine and vitamin D deficiency and was higher for Non-Classical CD (p 0.05). Associated diseases occurred in 10.9%, and type 1 diabetes was significant for the Non-Classical CD group (p = 0.04). Conclusion: The classical CD was the most prevalent profile and presented a decrease in the severity of symptoms however remain a higher rate of intestinal atrophy. Recurrent abdominal pain was the main symptom of Non-Classical CD. Extraintestinal manifestations and associated diseases presented an increasing trend of occurrence among cases of Non-Classical CD.

关键词： Celiac Disease Gluten Allergy Extra-Intestinal Manifestation Disease Associated with Celiac Disease

Sol-Gel Relative Humidity Sensors: Impact of Electrode Geometry on Performance in Soil Suction Measurements

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Journal of Sensor Technology 2017年第1期7卷 1-23页

作者： Rafaela Cardoso Gabriele Sarapajevaite Oleksandr Korsun susana Cardoso laura Ilharco Instituto Superior Técnico (IST) Universidade de Lisboa Lisbon Portugal Civil Engineering Research Innovation and Sustainability (CERIS) Institute of Construction Structures and Territory of IST (ICIST) Lisbon Portugal INESC-MN Microsystems and Nanotechnologies Lisbon Portugal CQFM Centro de Química-Física Molecular Instituto Superior Técnico (IST) Lisbon Portugal

This paper describes the experimental procedure followed to fabricate and validate sol-gel based RH sensors which will be incorporated in soil specimens for standard laboratorial tests. It is the first time such sensors were used for soil suction measurement. They are microfabricated relative humidity sensors (footprint area 11,000 μm × 22,000 μm) operating based on changes in electrical resistivity detected by a cerium doped silica titania film deposited using a sol-gel technique. Their design required gathering experts in several engineering specialties. The working principle of the sensors is based on water vapour equilibrium between the air in the soil and in the sol-gel pores, due to the contact between the two porous materials. The spacing between interdigitated aluminium electrodes was optimized to improve the sensing properties of the sol-gel. The calibration of the different prototypes was done against compacted clay, varying the spacing between 100 and 700 μm. The sensors were also incorporated in soil samples for suction measurement during wetting and drying paths. They were validated by comparing the readings with those from a water dew point potentiometer. From this study it was possible to determine the optimum electrodes spacing of 200 μm. Error was explained by sol-gel heterogeneity effect and by the resolution of the sensing area provided by the electrodes spacing. When comparing with other sensors operating inside soil specimens in standard laboratorial tests, these sol-gel sensors extend the operation range available with the alternative technologies: while conventional tensiometers measure suction ranges from 0 to 1.8 MPa, our sensors demonstrate good results between 1 to 10 MPa (and higher).

关键词： Microfabricated Interdigitated Electrodes Humidity Sensors Suction Unsaturated Soils

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抗原性生物标志物在结核分枝杆菌中的应用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 856-870页

作者： Elba RODRIGUEZ-HERNANDEZ laura Itzel QUINTAS-GRANADOS susana FLORES-VILLALVA Jorge Germinal CANTO-ALARCON Feliciano MILIAN-SUAZO Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias(INIFAP)Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento AnimalKm.1 Carretera a ColonAjuchitlan Colon76280ColonQueretaroMexico Universidad Mexiquense del Bicentenario Unidad de Estudios Superiores de TultitlanAvenida Ex-Hacienda de Portales s/nVilla EsmeraldaTultitlan Estado de Mexico54910TultitlanMexico Universidad Autonoma de Queretaro Facultadde Ciencias NaturalesAvenida de las Ciencias s/nJuriquillaDelegacion Santa Rosa Jauregui76230QueretaroMexico

研究和鉴定分枝杆菌与其宿主间相互作用的生物分子,对于确定分枝杆菌在入侵过程中的作用至关重要,并为相关疾病生物学和发病机制提供基础知识。分枝杆菌是一种古老的病原体,它为自己在宿主和环境中生存发展了复杂的策略,这可能与其参与... 详细信息

研究和鉴定分枝杆菌与其宿主间相互作用的生物分子,对于确定分枝杆菌在入侵过程中的作用至关重要,并为相关疾病生物学和发病机制提供基础知识。分枝杆菌是一种古老的病原体,它为自己在宿主和环境中生存发展了复杂的策略,这可能与其参与感染分子之间相互作用网络的复杂性有关。在结核病检测技术的发展过程中,一些生物标记物已经开始受到关注。研究最广泛的抗原有CFP-10、ESAT-6、Ag85A、Ag85B、CFP-7和PPE18。其中一些抗原已被作为生物标记来评估病原体和宿主感染反应。设计新颖而准确的诊断方法对控制全世界的结核病至关重要。目前,诊断方法是基于对感染个体体液反应分子的识别。因此,这些测试依赖于宿主产生免疫反应的能力,而免疫反应通常是异质的。在过去的20年里,人们特别重视多抗原诊断方法的设计,以提高敏感性和特异性水平。本文综述了结核分枝杆菌生物分子的研究和应用现状,以期为结核控制提供新的支持。

关键词：结核分枝杆菌重组抗原诊断生物标志物

Detection of KRAS G12D in colorectal cancer stool by droplet digital PCR

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World Journal of Gastroenterology 2017年第39期23卷 7087-7097页

作者： susana Olmedillas-López Dennis César Lévano-Linares Carmen laura Aúz Alexandre Luz Vega-Clemente Edurne León Sánchez Alejandro Villagrasa Jaime Ruíz-Tovar Mariano García-Arranz Damián García-Olmo Foundation Health Research Institute-Fundación Jiménez Díaz University Hospital Department of Surgery School of Medicine Universidad Autónoma de Madrid Department of Surgery Rey Juan Carlos University Hospital Department of Pathology Fundación Jiménez Díaz University Hospital Department of Biomedicine and Biotechnology Universidad de Alcalá Department of Surgery Fundación Jiménez Díaz University Hospital

AIM To assess KRAS G12 D mutation detection by droplet digital PCR(dd PCR) in stool-derived DNA from colorectal cancer(CRC) *** In this study, tumor tissue and stool samples were collected from 70 patients with stage Ⅰ-Ⅳ CRC diagnosed by preoperative biopsy. KRAS mutational status was determined by pyrosequencing analysis of DNA obtained from formalin-fixed paraffinembedded(FFPE) tumor tissues. The KRAS G12 D mutation was then analyzed by dd PCR in FFPE tumors and stool-derived DNA from patients with this point mutation. Wild-type(WT) tumors, as determined by pyrosequencing, were included as controls; analysis of FFPE tissue and stool-derived DNA by dd PCR was performed for these patients as *** Among the total 70 patients included, KRAS mutations were detected by pyrosequencing in 32(45.71%), whereas 38(54.29%) had WT tumors. The frequency of KRAS mutations was higher in left-sided tumors(11 located in the right colon, 15 in the left, and 6 in the rectum). The predominant point mutation was KRAS G12 D(14.29%, n = 10), which was more frequent in early-stage tumors(I-IIA, n = 7). In agreement with pyrosequencing results, the KRAS G12 D mutation was detected by dd PCR in FFPE tumor-derived DNA, and only a residual number of mutated copies was found in WT controls. The KRAS G12 D mutation was also detected in stool-derived DNA in 80% of all fecal samples from CRC patients with this point mutation. CONCLUSION dd PCR is a reliable and sensitive method to analyze KRAS G12 D mutation in stool-derived DNA from CRC patients, especially at early stages. This non-invasive approach is potentially applicable to other relevant biomarkers for CRC management.

关键词：微滴数字 PCR KRAS 凳子修理福尔马林嵌入石蜡 Pyrosequencing Colorectal 癌症

Maternal Understanding Regarding Women Nutrition during Breastfeeding

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Health 2018年第12期10卷 1661-1672页

作者： Gabriela Olagnero Luciana Barretto Adriana Wiedemann Raúl Terraza Mabel susana Poy laura López Scientific Coordination for Latin America Danone Nutricia Early Life Nutrition Buenos Aires Argentina School of Nutrition University of Buenos Aires Buenos Aires Argentina

Introduction: Breastfeeding mothers’ nutritional status affects milk quality and children’s nutrition in a key period for life. Objectives: Identifying and describing breastfeeding mothers’ social representations during this period related with nutrition as self-care;connotations referred to food products and supplements;post-partum weight retention and information sources consulted on this matter. Materials and Methods: Ten in depth interviews were performed in healthy adult breastfeeding mothers. Interviews were analyzed with a qualitative methodology considering Health Beliefs, PRECEDE and Health Promotion models, employing the Grounded Theory. Results: Women consider nutrition as a health conditioning factor and refer dietary changes implementation during pregnancy, which are not always kept during breastfeeding. Disorganization was mentioned regarding feeding and commensality, prioritizing their child’s health over their own. Vegetables and liquids are attributed to positive connotations, referring increased consumption. Certain foods are limited as they are considered less healthy (“junk food”, sweets, sodas, cookies, spices, coffee and mate) while others, like milk, have been associated with negative effects. Insufficient weight gain during pregnancy is valorized as an achievement due to pairs approval and appearance. Association between breastfeeding and previous weight recovery is weak and doubted. Lack of information on feeding and breastfeeding even among health professionals is recognized. In case of doubts, mothers follow the closest belief affectively. Conclusions: Identifying and characterizing beliefs and barriers for maternal eating practices allow including socio-cultural aspects both in the design of public health policies and in individual nutritional counseling.

关键词： Breastfeeding Maternal Feeding Perceptions Barriers Information

Innovative education and training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser matter interactions and high energy density physics: experimental diagnostics and simulations

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High Power Laser Science and Engineering 2020年第1期8卷 30-36页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil PBenis Andrea Ciardi Donna Cook Vasilios Dimitriou Brendan Dromey Ioannis Fitilis Giancarlo Gatti Anastasios Grigoriadis Marine Huault Jose Antonio Pérez Hernández Evaggelos Kaselouris Ondrej Klimo Michel Koenig George Koundourakis Milan Kucharik Jiri Limpouch Richard Liska Carlos Salgado Lopez Sophia Malko susana Olmos-Miguelanez Yannis Orphanos Valeria Ospina Nektarios APapadogiannis Stelios Petrakis Jan Psikal Maria Serena Rivetta Maria-ose Rodriguez-Conde Joao Jorge Santos Milan Sinor Alexandros Skoulakis Ioannis Tazes laura Tejada Pascual Calliope Tsitou Pavel Vachal Luca Volpe Jiri Vyskocil Steven White Mark Yeung Ghassan Zerouli Michael Tatarakis York Plasma Institute University of YorkHeslingtonYork YO105DQUK Hellenic Mediterranean University Institute of Plasma Physics and Lasers-IPPL74100 Rethymnon73133 ChaniaCreteGreece University of Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Department of Physics University of IoanninaGR 45110 IoanninaGreece LULI-CNRS CEASorbonne UniversiesEcole PolytechniqueInstitut Polytechnique de Paris-F-91128 Palaiseau CedexFrance Observatoire de Paris 5 Place J JanssenMeudon 92195France Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUK Centro de Láseres Pulsados(CLPU) Edificio M5Parque CientficoC/Adaja 837185 VillamayorSalamancaSpain University of Salamanca 37008 SalamancaSpain Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PragueBrehova 711519Prague 1Czech Republic University Institute for Educational Sciences University of Salamanca37008 SalamancaSpain Group of Research“Interaction and e Learning”(GRIAL) University of Salamanca37008 SalamancaSpain CLPU Laser-Plasma Chair at University of Salamanca 37008 SalamancaSpain

The second and final year of the Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme,where teaching takes place in five separate institutes with a range of different aims and styles of ***’in-class’time is limited to 4 weeks a year,and the programme spans 2 *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laser plasma interaction physics and inertial confinement *** are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Hellenic Mediterranean University and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just finished its second and final *** Learning Teaching Training activities have been held at the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University,the University of Salamanca and the Institute of Plasma Physics and Lasers of the Hellenic Mediterranean *** last of these institutes hosted two 2-week-long Intensive Programmes,while the activities at the other four universities were each 5 days in *** addition,a’Multiplier Event’was held at the University of Ioannina,which will be briefly *** this second year,the work has concentrated on training in both experimental diagnostics and simulation techniques appropriate to the study of plasma physics,high power laser matter interactions and high energy density *** nature of the programme will be described in detail,and some metrics relating to the activities carried out will be *** particular,this paper will f

关键词： laser plasma interactions postgraduate education

Development and Evaluation of the Human Hookworm Vaccine

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Development and Evaluation of the Human Hookworm Vaccine