Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule

作     者：Susana Laura González 

作者机构：Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquímica Humana Buenos Aires Laboratorio de Nocicepción y Dolor Neuropático Instituto de Biología y Medicina Experimental 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第10期

页      面：1846-1847页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from Consejo Nacional de Investigaciones Científicas y Tecnológicas(CONICET,PIP 112-201501-00266) Agencia Nacional de Promoción Científica y Técnica(PICT 2018-02152) Fundación RenéBarón and Fundación Williams 

主　　题：injuries disorders drugs 

摘      要：Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransmission *** the past decades,valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders,which usually overlap and critically contribute to long-term ***,up to now,no definite cures or effective disease-modifying therapies are available for any of these *** has led to an active search of novel therapeutic approaches,including the repositioning of existing drugs for new indications,as a valid approach to promptly move candidate molecules to clinical trials.