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Current cancer situation in China:good or bad news from the 2018 Global Cancer Statistics?

Cancer Communications 2019年第1期39卷 202-213页

作者： Rui-mei Feng Yi-Nan Zong su-mei cao Rui-Hua Xu Department of Cancer Prevention Research Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China

Cancer is the leading cause of death in China and depicting the cancer pattern of China would provide basic knowhows on how to tackle it more *** this study we have reviewed several reports of cancer burden,including the Global cancer statistics 2018 and Cancer statistics in China,2015,along with the GLOBCAN 2018 online database,to investigate the differences of cancer patterns between China,the United States(USA)and the United Kingdom(UK).An estimated 4.3 million new cancer cases and 2.9 million new cancer deaths occurred in China in *** to the USA and UK,China has lower cancer incidence but a 30%and 40%higher cancer mortality than the UK and USA,among which 36.4%of the cancer-related deaths were from the digestive tract cancers(stomach,liver,and esophagus cancer)and have relatively poorer *** comparison,the digestive cancer deaths only took up≤5%of the total cancer deaths in either USA or *** reasons for the higher mortality in China may be the low rate of early-stage cancers at diagnosis and non-uniformed clinical cancer treatment strategies performed by different *** is undergoing the cancer transition stage where the cancer spectrum is changing from developing country to developed country,with a rapidly increase cancer burden of colorectal,prostate,female breast cancers in addition to a high occurrence of infection-related and digestive *** incidence of westernized lifestyle-related cancers in China(*** cancer,prostate,bladder cancer)has risen but the incidence of the digestive cancers has decreased from 2000 to *** estimated 40%of the risk factors can be attributed to environmental and lifestyle factors either in China or other developed *** smoking is the single most important carcinogenic risk factor in China,contributing to~24.5%of cancers in *** infection is another important preventable cancer contributor which is responsible for~17%of *** prevent

关键词： GLOBCAN 2018 Cancer pattern China USA UK Carcinogenic risk factor Tobacco smoking Chronic infection Westernized lifestyles Cancer control strategies

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Familial nasopharyngeal carcinomas possess distinguished clinical characteristics in southern China

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Chinese Journal of Cancer Research 2014年第5期26卷 543-549页

作者： su-mei cao sui-Hong Chen Chao-Nan Qian Qing Liu Yun-Fei Xia State Key Laboratory of Oncology in South China and Department of Cancer Prevention Research Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China and Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China and Department of Radiation Oncology Sun Yat-Sen University Cancer Center

Objective： To compare clinical characteristics between familial nasopharyngeal carcinomas（NPCs） and sporadic NPCs in Guangdong province, China, a high-risk area.Methods： Between 1991 and 2001, 993 NPC patients treated at the Cancer Center of sun Yat-Sen University in Guangdong were randomly selected as probands. Information about NPC among the probands＇ relatives and other information were obtained from a retrospective review of the patients＇ medical records. The patients were divided into sporadic NPC, low-frequency familial NPC（one NPC patient in addition to the proband in three generations）, and high-frequency familial NPC（2 or more additional NPC patients in three generations） groups. Pathological and clinical characteristics were compared among these groups.Results： Of the 993 patients, 131（13.2%） had a familial history of NPC. The average age at diagnosis was the lowest in the high-frequency familial NPC group（39 years; P=0.048）. Although the overall survival（OS）, distant metastasis-free survival（DMFS）, and disease-free survival（DFS） rates did not differ between familial and sporadic NPCs, the locoregional recurrence-free survival（LRFS） rate increased in the order sporadic NPCs, low-frequency familial NPCs, and high-frequency familial NPCs（P=0.009）, with 5-year rates of 70%, 83%, and 87%, respectively. Multivariate analysis showed that family history of NPC was an independent favorable prognostic factor for LRFS, with adjusted hazard ratio（a HR） of 0.548, 95% CI（0.342-0.878）. The high LRFS for familial NPCs was mainly noted among young, advanced-stage patients who received continuous radiation treatment.Conclusions： Genetic factors may play an important role in the etiology of high-frequency familial NPC and underlie the early age of onset and sensitivity to radiotherapy.

关键词： Nasopharyngeal carcinoma(NPC) familial clinical behavior

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Estimation of cancer burden in Guangdong Province,China in 2009

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Chinese Journal of Cancer 2015年第12期34卷 594-601页

作者： su-mei cao Yan-Jun Xu Guo-Zhen Lin Qi-Hong Huang Kuang-Rong Wei Shang-Hang Xie Qing Liu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Cancer Prevention Sun Yat-sen University Cancer Center Institute of Control and Prevention for Chronic Non-infective Disease Guangdong Provincial Center for Disease Control and Prevention Department of Disease surveillance Guangzhou Center for Disease Control and Prevention Sihui Institute of Cancer Institute of Cancer Zhongshan People's Hospital

Background:surveying regional cancer incidence and mortality provides significant data that can assist in making health policy for local areas;however,the province- and region-based cancer burden in China is seldom *** this study,we estimated cancer incidence and mortality in Guangdong Province,China and presented basic information for making policies related to health resource allocation and disease ***:A log-linear model was used to calculate the sex-,age-,and registry-specific ratios of incidence to mortality(l/M) based on cancer registry data from Guangzhou,Zhongshan,and Sihui between 2004 and *** cancer incidences in 2009 were then estimated according to representative l/M ratios and the mortality records from eight death surveillance sites in Guangdong *** cancer incidences in each city were estimated by the corresponding sex- and age-specific incidences from cancer registries or death surveillance sites in each ***,the total and region-based cancer incidences and mortalities for the entire population of Guangdong Province were ***:The estimated l/M ratios in Guangzhou(3.658),Zhongshan(2.153),and Sihui(1.527) were significantly different(P < 0.001),with an average l/M ratio of *** differences in the estimated l/M ratios were observed between distinct age groups and the three cancer *** estimated l/M ratio in females was significantly higher than that in males(2.864 vs.2.027,P < 0.001).It was estimated that there were 163,376 new cancer cases(99,689 males and 63,687 females) in 2009;it was further estimated that 115,049 people(75,054 males and 39,995females) died from cancer in Guangdong Province in *** estimated crude and age-standardized rate of incidences(ASRI) in Guangdong Province were 231.34 and 246.87 per 100,000 males,respectively,and 156.98 and 163.57 per 100,000 females,*** estimated crude and age-standardized rate of mortalities(ASRM) in Guangdong Pro

关键词： Disease burden, Incidence-to-mortality ratio, Loq-linear model

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Incidence trend of nasopharyngeal carcinoma from 1987 to 2011 in Sihui County,Guangdong Province,South China:an age-period-cohort analysis

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Chinese Journal of Cancer 2015年第8期34卷 350-357页

作者： Li-Fang Zhang Yan-Hua Li Shang-Hang Xie Wei Ling sui-Hong Chen Qing Liu Qi-Hong Huang su-mei cao Department of Cancer Prevention Research Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine School of Public Health Sun Yat-sen University Sihui Cancer Institute

Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in Hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that the incidence of NPC in Sihui County,South China remained stable until 2002,but whether age,diagnosis period,and birth cohort affect the incidence of NPC remains ***:Age-standardized rates(ASRs) of NPC incidence based on the world standard population were examined in both males and females in Sihui County from 1987 to *** regression analysis was conducted to quantify the changes in incidence trends.A Poisson regression age-period-cohort model was used to assess the effects of age,diagnosis period,and birth cohort on the risk of ***:The ASRs of NPC incidence during the study period were 30.29/100,000 for males and 13.09/100,000 for *** incidence of NPC remained stable at a non-significant average annual percent change of 0.2%for males and-1.6%for females throughout the entire period.A significantly increased estimated annual percent change of 6.8%(95%confidence interval,0.1%-14.0%) was observed from 2003 to 2009 for *** relative risk of NPC increased with advancing age up to 50-59 and decreased at ages >60 *** period effect curves on NPC were nearly flat for males and *** birth cohort effect curve for males showed an increase from the1922 cohort to the 1957 cohort and a decrease *** females,there was an undulating increase in the relative risk from the 1922 cohort to the 1972 ***:The incidence trends for NPC remained generally stable in Sihui from 1987 to 2011,with an increase from 2003 to *** relative risks of NPC increased in younger females.

关键词：队列分析中国人群发病率鼻咽癌广东省全国人民代表大会龄期回归分析

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Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

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Cancer Communications 2018年第1期38卷 81-94页

作者： Meng-Jie Yang Jie Guo Yan-Fang Ye sui-Hong Chen Li-Xia Peng Chu-Yang Lin Ting Hu Shang-Hang Xie Chuan-Bo Xie Qi-Hong Huang Yu-Qiang Lu Qing Liu Chao-Nan Qian su-mei cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Cancer Prevention Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China School of Public Health Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Sihui Cancer Institute Sihui 526200GuangdongP.R.China

Background:The association of circulating inflammation markers with nasopharyngeal carcinoma(NPC)is still largely *** study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern ***:The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study(150 NPC patients and 150 controls)using multiplex assay *** levels were categorized into two or more groups based on the proportion of sample measurements that was above the lower limit of *** ratios(ORs)and 95%confidence intervals(CIs)relating the serum marker concentration to the risk of NPC were computed by multivariable logistic regression *** associations were validated in 60 patients with NPC and 120 con-trols in a subsequent nested case-control study within a NPC screening *** interactions between serum cytokines and Epstein-Barr virus(EBV)relating to the risk of NPC were assessed using a likelihood ratio ***:The levels of serum macrophage inflammatory protein(MIP)-1αand MIP-1βin the highest categories were associated with a decreased risk of NPC in both the case-control study(MIP-1α:OR=0.49,95%CI=0.26-0.95;MIP-1β:OR=0.47,95%CI=0.22-1.00)and the nested case-control study(MIP-1α:OR=0.13,95%CI=0.03-0.62;MIP-1β:OR=0.20,95%CI=0.04-0.94),compared with those in the lowest ***,individuals with lower levels of these two cytokine markers who were EBV seropositive presented with a largely higher risk of NPC compared with patients with higher levels who were EBV seronegative in both the case-control study(MIP-1α:OR=16.28,95%CI=7.11-37.23;MIP-1β:OR=12.86,95%CI=5.9-28.05)and the nested case-control study(MIP-1α:OR=86.12,95%CI=10.58-701.03;MIP-1β:OR=115.44,95%CI=13.92-957.73).Conclusions:Decreased preclinical MIP-1αand MIP-1βlevels might be associated with a subsequently increased risk of NPC.

关键词： Nasopharyngeal carcinoma Prospective study Inflammatory cytokine Macrophage inflammatory protein Epstein-Barr virus

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subtype distribution and long-term titer luctuation patterns of serum anti-Epstein–Barr virus antibodies in a non-nasopharyngeal carcinoma population from an endemic area in South China:a cohort study

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Chinese Journal of Cancer 2016年第9期35卷 447-454页

作者： Jin-Lin Du sui-Hong Chen Qi-Hong Huang Shang-Hang Xie Yan-Fang Ye Rui Gao Jie Guo Meng-Jie Yang Qing Liu Ming-Huang Hong su-mei cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China. Department of Cancer Prevention Research Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China. School of Public Health Sun Yat-sen UniversityGuang-zhou 510080GuangdongP.R.China. School of Public Health Guangdong Medical UniversityDongguan 523808GuangdongP.R.China. Sihui Cancer Institute Sihui 526200GuangdongP.R.China. Department of Clinical Trial Center Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China.

Background: Serum immunoglobulin A antibodies against Epstein–Barr virus(EBV), viral capsid antigen(VCA?Ig A) and early antigen(EA?Ig A), are used to screen for nasopharyngeal carcinoma(NPC) in endemic areas. However, their routine use has been questioned because of a lack of specificity. This study aimed to determine the distributions of different subtypes of antibody and to illustrate how the natural variation patterns affect the specificity of screening in non?NPC ***: The distribution of baseline VCA?IgA was analyzed between sexes and across 10?year age groups in 18,286 non?NPC participants using Chi square tests. Fluctuations in the VCA?IgA level were assessed in 1056 non?NPC participants with at least two retests in the first 5?year period(1987–1992) after the initial screening using the Kaplan–meier ***: The titers of VCA?Ig A increased with age(P < 0.001). Using a previous serological definition of high NPC risk, nasopharyngeal endoscopy and/or nasopharyngeal biopsy would be recommended in 55.5% of the non?NPC partici?pants with an initial VCA?Ig A?positive status and in 20.6% with an initial negative status during the 5?year follow?up. However, seroconversions were common; 85.2% of the participants with a VCA?Ig A?positive status at baseline con?verted to negative, and all VCA?Ig A?negative participants changed to positive at least once during the 5?year follow?up. The EA?Ig A status had a high seroconversion probability(100%) from positive to negative; however, it had a low probability(19.6%) from negative to ***: Age? and sex?specific cutoff titer values for serum anti?EBV antibodies as well as their specific titer fluc?tuation patterns should be considered when defining high NPC risk criteria for follow?up diagnostics and monitoring.

关键词：病毒抗体波动模式鼻咽癌血清学中国南方地区队列研究亚型人群

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Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome

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Chinese Journal of Cancer 2010年第8期29卷 721-728页

作者： su-mei cao Jie-Kai YU Qiu-Yan Chen Ning-Wei Li Yan-Qun Xiang Chao-Nan Qian Xun HU Chang-Qing Zhang Dan Xie Xiang Guo State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Epidemiology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Cancer Institute Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 P. R. China Department of Nasopharyngeal Carcinoma Sun Yat-senUniversity Cancer Center Guangzhou Guangdong 510060 P. R. China Research Institute Sun Yat-sen University Cancer CenterGuangzhou Guangdong 510060 P. R. China

Background and Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult due to the insufficient specificity of the conventional examination method. This study was to investigate potential and consistent biomarkers for NPC, particularly for early detection of NPC. Methods: A proteomic pattern was identified in a training set (134 NPC patients and 73 control individuals) using the surface-enhanced laser desorption and ionization-mass spectrometry (SELDI-MS), and used to screen the test set (44 NPC patients and 25 control individuals) to determine the screening accuracy. To confirm the accuracy, it was used to test another group of 52 NPC patients and 32 healthy individuals at 6 months later. Results: Eight proteomic biomarkers with top-scored peak mass/charge ratios (m/z) of 8605 Da, 5320 Da, 5355 Da, 5380 Da, 5336 Da, 2791 Da, 7154 Da, and 9366 Da were selected as the potential biomarkers of NPC with a sensitivity of 90.9% (40/44) and a specificity of 92.0% (23/25). The performance was better than the current diagnostic method by using the Epstein-Barr virus (EBV) capsid antigen IgA antibodies (VCA/IgA). Similar sensitivity (88.5%) and specificity (90.6%) were achieved in another group of 84 samples. Conclusion: SELDI-MS profiling might be a potential tool to identify patients with NPC, particularly at early clinical stages.

关键词：激光解吸电离蛋白质组鼻咽癌表面增强质谱法生物标志物 SELDI 血清

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Secular trend analysis of lung cancer incidence in Sihui city,China between 1987 and 2011

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Chinese Journal of Cancer 2015年第8期34卷 365-372页

作者： Jin-Lin Du Xiao Lin Li-Fang Zhang Yan-Hua Li Shang-Hang Xie Meng-Jie Yang Jie Guo Er-Hong Lin Qing Liu Ming-Huang Hong Qi-Hong Huang Zheng-Er Liao su-mei cao sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Cancer Prevention Research Sun Yat-sen University Cancer Center School of Public Health Guangdong Medical University Sihui Cancer Institute Department of Clinical Trial Center Sun Yat-sen University Cancer Center Department of Cancer Screening Sun Yat-sen University Cancer Center

Background:With industrial and economic development in recent decades in South China,cancer incidence may have changed due to the changing lifestyle and ***,the trends of lung cancer and the roles of smoking and other environmental risk factors in the development of lung cancer in rural areas of South China remain *** purpose of this study was to explore the lung cancer incidence trends and the possible causes of these ***:Joinpoint regression analysis and the age-period-cohort(APC) model were used to analyze the lung cancer incidence trends in Sihui,Guangdong province,China between 1987 and 2011,and explore the possible causes of these ***:A total of 2,397 lung cancer patients were involved in this study.A 3-fold increase in the incidence of lung cancer in both sexes was observed over the 25-year *** regression analysis showed that while the incidence continued to increase steadily in females during the entire period,a sharp acceleration was observed in males starting in *** full APC model was selected to describe age,period,and birth cohort effects on lung cancer incidence trends in *** age cohorts in both sexes showed a continuously significant increase in the relative risk(RR)of lung cancer,with a peak in the eldest age group(80-84 years).The RR of lung cancer showed a fluctuating curve in both *** birth cohorts identified an increased trend in both males and females;however,males had a plateau in the youngest cohorts who were born during ***:Increasing trends of the incidence of lung cancer in Sihui were dominated by the effects of age and birth *** aging,smoking,and environmental changes may play important roles in such trends.

关键词：发病率四会市肺癌中国队列研究发病趋势回归分析社会老龄化

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie su Weicheng Feng Yaona Lai Kongli Huang Dandan cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

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癌症 2015年第12期34卷 563-572页

作者： Fu-Tuo Feng Qian Cui Wen-Sheng Liu Yun-Miao Guo Qi-Sheng Feng Li-Zhen Chen Miao Xu Bing Luo Da-Jiang Li Li-Fu Hu Jaap M.Middeldorp Octavia Ramayanti Qian Tao su-mei cao Wei-Hua Jia Jin-Xin Bei Yi-Xin Zeng sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Pathology VU University Medical Center Department of Medical Microbiology Qingdao University Medical College Department of Experimental Research Sun Yat-sen University Cancer Center Department of Microbiology Tumor and Cell BiologyKarolinska Institute Department of Clinical Oncology The Chinese University of Hong Kong Department of Epidemiology Cancer Prevention CenterSun Yat-sen University Cancer Center

Background:Epstein-Barr virus(EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma(NPC),which has a high incidence in certain *** study aimed to address how EBV variations contribute to the risk of ***:Using logistic regression analysis and based on the sequence variations at EBV-encoded RPMS1,a multistage association study was conducted to identify EBV variations associated with NPC risk.A protein degradation assay was performed to characterize the functional relevance of the RPMS1 ***:Based on EBV-encoded RPMS1 variations,a single nucleotide polymorphism(SNP) in the EBV genome(locus 155391:G>A,named Gl 55391 A) was associated with NPC in 157 cases and 319 healthy controls from an NPC endemic region in South China[P sults were further validated in three independent cohorts from the NPC endemic region(P < 0.001,OR = 5.20,95%CI3.18-8.50 in 168 cases vs.241 controls,and P < 0.001,OR = 5.27,95%CI 4.06-6.85 in 726 cases vs.880 controls) and a non-endemic region(P < 0.001,OR = 7.52,95%CI 3.69-15.32 in 58 cases vs.612 controls).The combined analysis in 1109 cases and 2052 controls revealed that the SNP Gl 55391 A was strongly associated with NPC(P< 0.001,OR = 5.27,95%CI 4.31-6.44).Moreover,the frequency of the SNP Gl 55391 A was associated with NPC incidence but was not associated with the incidences of other EBV-related ***,the protein degradation assay showed that this SNP decreased the degradation of the oncogenic RPMS1 ***:Our study identified an EBV variation specifically and significantly associated with a high risk of *** findings provide insights into the pathogenesis of NPC and strategies for prevention.

关键词： Epstein-Barr virus Nasopharyngeal carcinoma RPMS1 Association

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