Incidence trend of nasopharyngeal carcinoma from 1987 to 2011 in Sihui County,Guangdong Province,South China:an age-period-cohort analysis

作     者：Li-Fang Zhang Yan-Hua Li Shang-Hang Xie Wei Ling Sui-Hong Chen Qing Liu Qi-Hong Huang Su-Mei Cao 

作者机构：Department of Cancer Prevention ResearchSun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine School of Public HealthSun Yat-sen University Sihui Cancer Institute 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2015年第34卷第8期

页      面：350-357页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：队列分析 中国人群 发病率 鼻咽癌 广东省 全国人民代表大会 龄期 回归分析 

摘      要：Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in Hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that the incidence of NPC in Sihui County,South China remained stable until 2002,but whether age,diagnosis period,and birth cohort affect the incidence of NPC remains ***:Age-standardized rates(ASRs) of NPC incidence based on the world standard population were examined in both males and females in Sihui County from 1987 to *** regression analysis was conducted to quantify the changes in incidence trends.A Poisson regression age-period-cohort model was used to assess the effects of age,diagnosis period,and birth cohort on the risk of ***:The ASRs of NPC incidence during the study period were 30.29/100,000 for males and 13.09/100,000 for *** incidence of NPC remained stable at a non-significant average annual percent change of 0.2%for males and-1.6%for females throughout the entire period.A significantly increased estimated annual percent change of 6.8%(95%confidence interval,0.1%-14.0%) was observed from 2003 to 2009 for *** relative risk of NPC increased with advancing age up to 50-59 and decreased at ages 60 *** period effect curves on NPC were nearly flat for males and *** birth cohort effect curve for males showed an increase from the1922 cohort to the 1957 cohort and a decrease *** females,there was an undulating increase in the relative risk from the 1922 cohort to the 1972 ***:The incidence trends for NPC remained generally stable in Sihui from 1987 to 2011,with an increase from 2003 to *** relative risks of NPC increased in younger females.