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中华精神科杂志 2010年第1期43卷 3-7页

作者：武牡丹李春波金华 John m.davis D-69120德国海德堡大学心身医学和临床医学系内科学Ⅱ 上海交通大学医学院附属精神卫生中心生化药理研究室美国加州大学圣迭亚哥分校精神医学系美国芝加哥大学精神医学系

目的了解国内近15年公开发表的与精神障碍治疗相关的临床研究文献的进展及质量状况.方法以＂临床治疗＂＂临床试验＂＂随机＂＂对照＂＂双盲＂＂单盲＂＂盲法＂为关键词,检索中国生物医学文献数据库、中国医院知识数据库、维普中文电... 详细信息

目的了解国内近15年公开发表的与精神障碍治疗相关的临床研究文献的进展及质量状况.方法以＂临床治疗＂＂临床试验＂＂随机＂＂对照＂＂双盲＂＂单盲＂＂盲法＂为关键词,检索中国生物医学文献数据库、中国医院知识数据库、维普中文电子期刊数据库、万方数据库于1992-2006年以中文公开发表的与精神障碍治疗相关的临床研究文献.对文献数量、治疗病种、治疗方法及若干研究质量指标进行综合分析.同时,根据文献中的＂随机＂＂对照＂＂盲法＂等研究方法的说明对所有论文进行质量评价.临床试验方法学质量的评估部分参照Jadad评分量表,结合研究中的对照组设置情况进行评分（0～5分）.结果共纳入分析文献3667篇.研究涉及的疾病主要为精神分裂症（34.0%）、抑郁障碍（22.4%）、痴呆（7.8%）、躯体疾病伴发精神障碍（6.6%）和焦虑障碍（6.4%）.治疗方法以药物治疗为主,占82.2%.18.1%的研究未采用随机化;59.3%提到＂随机＂,但未说明具体随机方法;14.8%的随机方法为伪随机;7.9%的研究方法符合随机化的原则.尽管98.1%的研究设置了对照组,但仅16.6%采用了盲法,其中双盲占13.3%.根据文献的研究方法说明,评分为0,1,2,3,4,5分的文献分别占1.9%,28.1%,49.0%,9.4%,9.3%,2.3%,平均为2.03分.结论近15年来,国内以中文发表的精神障碍治疗相关的研究报道数量有显著增加,但其中大部分临床研究报告的质量仍偏低.

关键词：文献计量学临床试验精神障碍治疗结果评价(卫生保健)

Is glial hem. oxygenase-1 suppression in neurodegenerative disorders perm.ssive for neural repair?

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Neural Regeneration Research 2015年第2期10卷 208-210页

作者： Hym.n m. Schipper Bloom.ield Centre for Research in Aging Lady Davis Institute for Medical Research Jewish General Hospital Department of Neurology &Neurosurgery and Department. of Medicine Mc Gill University

＇Core＇ neuropathology of degenerative central nervous system.（CNS） disorders The com.on hum.n neurodegenerative disorders （Alzheim.r＇s disease （AD）, Parkinson＇s disease （PD）, am.otrophic lateral sclerosis, etc.） vary with respect to risk factors, ages of onset, sex predilections, neuraxial regions affected, hallm.rk cellular inclusions, behavioral and neurological sym.tom., and responses to treatm.nt. Despite these differences, there appears to be a set of ＇core＇ neuropathological features shared am.ng these and related entities. Com.on to these conditions are 1） pathological deposition of non-transferrin bound iron, 2） oxidative stress and associated protein, lipid and nucleic acid m.difications, 3） m.tochondrial m.m.rane dam.ge and bioenergetic failure, and 4） m.croautophagy in the affected neural tissues.

关键词： gene HO Is glial hem. oxygenase-1 suppression in neurodegenerative disorders perm.ssive for neural repair GFAP

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印度板块和亚洲大陆在何时何地碰撞

地质通报 2008年第9期27卷 1351-1370页

作者： Jonathan C Aitchison Jason R Ali Aileen m.davis 戴紧根(译) 赵西西(校) 香港大学地球科学系青藏高原研究组中国香港不详

印度板块和亚洲大陆的初始碰撞时间是所有相关的喜马拉雅-西藏造山体系演化模式的主控条件,并严重影响到对众多与青藏高原隆升和东亚大陆挤出相关的地质过程速率的解释,以及对新生代全球气候变化的理解。尽管印度板块和亚洲大陆汇聚的... 详细信息

印度板块和亚洲大陆的初始碰撞时间是所有相关的喜马拉雅-西藏造山体系演化模式的主控条件,并严重影响到对众多与青藏高原隆升和东亚大陆挤出相关的地质过程速率的解释,以及对新生代全球气候变化的理解。尽管印度板块和亚洲大陆汇聚的速率在55m.突然减缓被广泛地认为是初始碰撞的标志,但这次碰撞所造成的主要构造效应直到20多个百万年以后才显现出来。对印度板块和亚洲大陆相对位置的重新估算,表明它们在55m.时并没有达到可以彼此发生碰撞的距离。基于来自西藏新的野外证据和对已有数据的重新评估,认为初始碰撞发生在始新世—渐新世之交(约34m.),并对55m.时发生的地质事件提出了另一种解释。

关键词：印度板块亚洲大陆碰撞喜马拉雅-西藏

m.ltiplexed Profiling of Extracellular Vesicles for Biom.rker Developm.nt

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Nano-m.cro Letters 2022年第1期14卷 59-94页

作者： Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason davis George K.Tofaris Nuffield Departm.nt of Clinical Neurosciences New Biochemistry BuildingUniversity of OxfordOxford OX13QUUK Departm.nt of Chem.stry University of OxfordOxford OX13QZUK School of Life and Health Sciences The Chinese University of Hong KongShenzhen 518172People’s Republic of China Derm.tology Hospital Southern Medical UniversityGuangzhou 510091People’s Republic of China Kavli Institute for Nanoscience Discovery New Biochemistry BuildingUniversity of OxfordOxfordUK

Extracellular vesicles(EVs)are cell-derived m.m.ranous particles that play a crucial role in m.lecular trafficking,intercellular transport and the egress of unwanted *** have been im.licated in m.ny diseases including cancer and *** are detected in all bodily fluids,and their protein and nucleic acid content offers a m.ans of assessing the status of the cells from.which they *** such,they provide opportunities in biom.rker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective m.nitoring of *** sim.ltaneous assaying of m.ltiple EV-derived m.rkers will be required for an im.actful practical application,and m.ltiplexing platform. have evolved with the potential to achieve ***,we provide a com.rehensive overview of the currently available m.ltiplexing platform. for EV analysis,with a prim.ry focus on m.niaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency.

关键词： m.ltiplexed profiling Extracellular vesicles Exosom.s Liquid biopsy Point-of-care Biom.rker

m.tastatic appendiceal cancer treated with Yttrium.90 radioem.olization and system.c chem.therapy:A case report

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World Journal of Radiology 2019年第9期11卷 116-125页

作者： Am.arish P Bhat Philip A Schuchardt Roopa Bhat Ryan m.davis Sindhu Singh Departm.nt of Vascular and Interventional Radiology University of Missouri ColumbiaColumbiaMO 65212United States Departm.nt of m.dicine Section of Hematology-OncologyUniversity of Missouri-ColumbiaColumbiaMO 65212United States

BACKGROUND Prim.ry appendiceal cancers are rare,and they generally present with liver and/or peritoneal *** there are no guidelines to treat m.tastatic appendiceal cancer,and hence they are treated as m.tastatic colorectal *** Yttrium.90(Y-90)radioem.olization(RE)with system.c chem.therapy early in the treatm.nt of right sided colon cancers has been shown to im.rove *** on this data,a com.ination of system.c chem.therapy and Y-90 RE was used to treat a case of m.tastatic appendiceal *** SUm.ARY A 76-year-old m.le presented to the em.rgency room.with progressive right lower quadrant pain.A Com.uted Tom.graphy of the abdom.n and pelvis was perform.d which showed acute appendicitis and contained *** laparoscopic appendectom. was then followed by histological analysis,which was significant for appendiceal *** com.lete workup he underwent right hem.colectom. and lym.h node *** received adjuvant chem.therapy as the local lym.h nodes were ***-up im.ging was significant for liver *** to rapid growth of the liver lesions and new peritoneal nodules,the patient was treated with a com.ination of Y-90 RE and folinic acid,fluorouracil,and irinotecan with bevacizum.b and not m.crowave ablation as previously *** up im.ging dem.nstrated com.lete response of the liver *** 12-m. follow-up,the patient continued to enjoy good quality of life with no recurrent *** Utilization of Y-90 RE concom.tantly with system.c chem.therapy early in the treatm.nt of appendiceal cancer m.y provide im.roved control of this otherwise aggressive cancer.

关键词： Colorectal cancer Liver m.tastases Radioem.olization Yttrium 90 m.crospheres Appendix cancer with peritoneal m.tastasis Hypertherm.c intraperitoneal chem.therapy Case report

Sonicating bees dem.nstrate flexible pollen extraction without instrum.ntal learning

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Current Zoology 2019年第4期65卷 425-436页

作者： Callin m. Switzer Avery L. Russell Daniel R. Papaj Stacey A. Com.es Robin Hopkins Departm.nt of Organism.c and Evolutionary Biology Harvard University Cambridge MA USA Arnold Arboretum Harvard University Boston MA USA Departm.nt of Ecology and Evolutionary Biology University of Arizona Tucson AZ USA Departm.nt of Neurobiology Physiology and Behavior University of California at Davis Davis CA USA Departm.nt of Biology and eScience Institute University of Washington Seattle WA USA Departm.nt of Biological Sciences University of Pittsburgh Pittsburgh PA USA

Pollen collection is necessary for bee survival and im.ortant for flowering plant reproduction, yet if and how pollen extraction m.tor routines are m.dified with experience is largely unknown. Here, we used an autom.ted reward and m.nitoring system.to evaluate m.dification in a com.on pollen-extraction routine, floral sonication. Through a series of laboratory experim.nts with the bum.lebee, Bom.us im.atiens, we exam.ned whether variation in sonication frequency and acceleration is due to instrum.ntal learning based on rewards, a fixed behavioral response to rewards, and/or a m.chanical constraint. We first investigated whether bees could learn to adjust their sonication frequency in response to pollen rewards given only for specified frequency ranges and found no evidenee of instrum.ntal learning. However, we found that absenee versus receipt of a pollen reward did lead to a predictable behavioral resp on se, which depe nded on bee size. Fin ally, we found som. evide nee of m.chanical con straints, in that flower m.ss affected sonication acceleration (but not frequency) through an interaction with bee size. In generalz larger bees showed m.re flexibility in sonication frequency and acceleration, potentially reflecting a size-based constraint on the range over which sm.ller bees can m.dify frequency and accelerati on. Overall our results show that although bees did not display instrum.ntal learning of sonication frequency, their sonication m.tor routine is nevertheless flexible.

关键词： Bom.us im.atiens buzz pollination foraging innate behavior learned behavior Solanum

近500年来喜马拉雅山达索普冰芯中尘埃含量变化与西、南亚及北非干旱化趋势

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第四纪研究 2012年第1期32卷 53-58页

作者：王宁练姚檀栋 L.G.Thom.son m.E.davis 中国科学院寒区旱区环境与工程研究所冰冻圈科学国家重点实验室兰州730000 中国科学院青藏高原研究所北京100085 俄亥俄州立大学伯德极地研究中心美国哥伦布市43210

本文重建了近500年来喜马拉雅山中段达索普冰芯中尘埃浓度与尘埃沉积通量的变化历史,谱分析结果表明它们的变化均存在较显著的12.3年、9.8年、7.4年、6.1年和5.3年周期。该冰芯中尘埃含量与净积累量之间不存在任何相关性,说明其尘埃可... 详细信息

本文重建了近500年来喜马拉雅山中段达索普冰芯中尘埃浓度与尘埃沉积通量的变化历史,谱分析结果表明它们的变化均存在较显著的12.3年、9.8年、7.4年、6.1年和5.3年周期。该冰芯中尘埃含量与净积累量之间不存在任何相关性,说明其尘埃可能主要来源于上风方向的远源地区。基于后向轨迹法,并结合该地区附近已有的气溶胶研究结果,认为西、南亚甚至北非地区可能是该冰芯中尘埃物质的主要源区。近500年来达索普冰芯中尘埃沉积通量的增加趋势,反映了其源区干旱程度的加重趋势。

关键词：达索普冰芯尘埃干旱化气候变化

Apoptosis inhibitor of m.crophage and diabetic kidney disease

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Cellular & m.lecular Im.unology 2019年第5期16卷 521-521页

作者： Tim.thy m.E.davis Kirsten E.Peters Richard Lipscom.e Faculty of Health and m.dical Sciences Medical SchoolUniversity of Western AustraliaFremantleWestern AustraliaAustralia Proteom.cs International PerthWestern AustraliaAustralia

Dear Editor,m.yazaki et *** reviewed the role of the apoptosis inhibitor of m.crophage(AIm.protein,also known as CD5 antigen-like(CD5L),as an apoptosis inhibitor that supports the survival of m.crophages and protects against disease when it is in its free‘attacker’form.after release from.its circulating‘carrier’Igm.1 In particular,during acute kidney injury(AKI),evidence suggests that AIm.is released system.cally from.the Igm.pentam.r,resulting in increased urinary excretion of free AIm.which exerts its local scavenging activity.

关键词： kidney m.crophage al.

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应用非标准分析