Metastatic appendiceal cancer treated with Yttrium 90 radioembolization and systemic chemotherapy:A case report

作     者：Ambarish P Bhat Philip A Schuchardt Roopa Bhat Ryan M Davis Sindhu Singh 

作者机构：Department of Vascular and Interventional RadiologyUniversity of Missouri ColumbiaColumbiaMO 65212United States Department of MedicineSection of Hematology-OncologyUniversity of Missouri-ColumbiaColumbiaMO 65212United States 

出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第9期

页      面：116-125页

学科分类：10[医学] 

主　　题：Colorectal cancer Liver metastases Radioembolization Yttrium 90 microspheres Appendix cancer with peritoneal metastasis Hyperthermic intraperitoneal chemotherapy Case report 

摘      要：BACKGROUND Primary appendiceal cancers are rare,and they generally present with liver and/or peritoneal *** there are no guidelines to treat metastatic appendiceal cancer,and hence they are treated as metastatic colorectal *** Yttrium 90(Y-90)radioembolization(RE)with systemic chemotherapy early in the treatment of right sided colon cancers has been shown to improve *** on this data,a combination of systemic chemotherapy and Y-90 RE was used to treat a case of metastatic appendiceal *** SUMMARY A 76-year-old male presented to the emergency room with progressive right lower quadrant pain.A Computed Tomography of the abdomen and pelvis was performed which showed acute appendicitis and contained *** laparoscopic appendectomy was then followed by histological analysis,which was significant for appendiceal *** complete workup he underwent right hemicolectomy and lymph node *** received adjuvant chemotherapy as the local lymph nodes were ***-up imaging was significant for liver *** to rapid growth of the liver lesions and new peritoneal nodules,the patient was treated with a combination of Y-90 RE and folinic acid,fluorouracil,and irinotecan with bevacizumab and not microwave ablation as previously *** up imaging demonstrated complete response of the liver *** 12-mo follow-up,the patient continued to enjoy good quality of life with no recurrent *** Utilization of Y-90 RE concomitantly with systemic chemotherapy early in the treatment of appendiceal cancer may provide improved control of this otherwise aggressive cancer.