Apoptosis inhibitor of macrophage and diabetic kidney disease

作     者：Timothy M.E.Davis Kirsten E.Peters Richard Lipscombe 

作者机构：Faculty of Health and Medical SciencesMedical SchoolUniversity of Western AustraliaFremantleWestern AustraliaAustralia Proteomics InternationalPerthWestern AustraliaAustralia 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2019年第16卷第5期

页      面：521-521页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：kidney macrophage al. 

摘      要：Dear Editor,Miyazaki et *** reviewed the role of the apoptosis inhibitor of macrophage(AIM)protein,also known as CD5 antigen-like(CD5L),as an apoptosis inhibitor that supports the survival of macrophages and protects against disease when it is in its free‘attacker’form after release from its circulating‘carrier’IgM.1 In particular,during acute kidney injury(AKI),evidence suggests that AIM is released systemically from the IgM pentamer,resulting in increased urinary excretion of free AIM,which exerts its local scavenging activity.