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Journal of Computer science & Technology 2007年第3期22卷 379-386页

作者：于立国 srini Ramaswamy Computer science and Informatics Indiana University south Bend South BendIN 46615U.S.A. Department of Computer science University of Arkansas at Little Rock Little RockAR 72204U.S.A.

Component dependency is an important software measure. It is directly related to software understandability, maintainability, and reusability. Two important parameters in describing component dependency are the type of coupling between two components and the type of the dependent component. Depending upon the different types of coupling and the type of the dependent components, there can be different effects on component maintenance and component reuse. In this paper, we divide dependent components into three types. We then classify various component dependencies and analyze their effects on maintenance and reuse. Based on the classification, we present a dependency metric and validate it on 11 open-source Java components. Our study shows that a strong correlation exists between the measurement of the dependency of the component and the effort to reuse the component. This indicates that the classification of component dependency and the suggested metric could be further used to represent other external software quality factors.

关键词： dependency maintenance metric object-oriented software reuse

Induction of human dendritic cell maturation by naïve and memory B-cell subsets requires different activation stimuli

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Cellular & Molecular Immunology 2018年第12期15卷 1074-1076页

作者： Mohan s.Maddur srini V.Kaveri Jagadeesh Bayry Institut National de la santéet de la Recherche Médicale Paris F-75006France Centre de Recherche des Cordeliers EquipeImmunopathologie et Immunointervention ThérapeutiqueParis F-75006France sorbonne Université Paris F-75006France UniversitéParis Descartes Sorbonne Paris CitéParis F-75006France Present address:Pfizer Inc.Pearl RiverNew YorkNYUSA

Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune *** outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation *** we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.

关键词： activation immune maturation

mpaired regulatory T cell function in autoimmune Jiseases： are microRNAs the culprits？

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Cellular & Molecular Immunology 2016年第2期13卷 135-137页

作者： Varun K sharma srini V Kaveri Jagadeesh Bayry Institut National de la sante et de la Recherche Medicale Unit6 1138 Paris France Centre de Recherche des Cordeliers Equipe - Imm unopathology and therapeutic immunointervention Paris France International Associated Laboratory IMPACT Institut National de la Sante et de la Recherche Medicale Paris France and Indian Council of Medical Research India National Institute of Immuno- haematology Mumbai India sorbonne Universites UPMC Univ Paris 06 UMR S 1138 Paris France Universite Paris Descartes Sorbonne Paris Cite UMR S 1138 Paris France

MicroRNAs （miRNAs） are evolu- tionarily conserved small non-coding RNA sequences, approximately 22 nucleotides in length, that act as negative regulators of target genes via binding to the 3＇-untranslated region of... 详细信息

关键词： microRNA 调节性T细胞免疫功能 miRNAs RNA序列 mRNA 非翻译区非编码

Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation

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Cellular & Molecular Immunology 2015年第5期12卷 650-652页

作者： Mohan s Maddur Jamma Trinath Magalie Rabin Francis Bolgert Moneger Guy Jean-Michel Vallat Laurent Magy Kithiganahalli N Balaji srini V Kaveri Jagadeesh Bayry Institut National de la sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris Descartes Paris France Department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et service de Neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IVIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin E2 （PGE2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.

关键词： associated increased prostaglandin

Adaptive Regulator for Networked Control systems: MATLAB and True Time Implementation

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Patterns of medication use for the treatment of menopausal symptoms before and after the women’s health initiative;implications for decision-making practices of women and women’s health professionals

第25届中国控制与决策会议

作者： seshadhri srinivasan Mishiga Vallabhan srini Ramaswamy lle Kotta Institute of Cybernetics Tallinn University of Technology

Networked Control systems （NCss） employ digital network for transmitting control and monitoring information among system components. Control information over digital network may be delayed due to transmission and this can adversely affect the control performance. To achieve desired performance in the presence of delays the controller needs to modify its gains based on the channel delay. In this paper, we propose a simple adaptive regulator that uses the first order approximation for computing the controller gains based on prior knowledge of channel delays from experiments. simulation results indicate that the adaptive regulator performs well even when we model the delay via Gaussian distribution. Delay samples obtained from MODBUs over TCP/IP and data-networks are used to illustrate the performance of the controller. The controller is implemented in True Time to illustrate its real-time performance.

关键词： Networked Control systems (NCss) adaptive control random delays linear quadratic regulator (LQR) Adaptive regulator (AR)

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Health 2011年第7期3卷 416-422页

作者： Chioma Uzoigwe smith srini Rajagopalan shiva sajjan shuvayu sankar sen Wenchen Kenneth Wu Henry Hu 不详

Background: The Women’s Health Initiative (WHI) published findings in 2002 that changed the perception of the use of hormone replacement therapy (HRT) for the reduction of cardiovascular risks. Menopausal women using HRT for the relief of vasomotor symptoms were advised to use the lowest possible dose of HRT over the shortest possible duration. Objective: This study sought to examine patterns of HRT use for the treatment of menopausal symptoms before and after the WHI among women at least 40 years of age. Methods: A retrospective analysis was performed on a total of 1367 women in the pre-WHI group and 6467 women in the post-WHI group using the U.s. General Electric (GE) Centricity electronic medical record database. Menopause diagnosis was assessed using ICD-9 codes. Clinical characteristics and medication use were assessed for women with at least 3 years of enrollment (1 year baseline, 2 years follow-up). Results: The proportion of women in the post-WHI group that initiated HRT was significantly less than that of women in the pre-WHI group (31.3% vs. 56.9%, respectively;p se declined significantly (21.9% pre-WHI cohort vs. 7.2% post- WHI cohort, p ses in non-HRT use, namely ssRIs (15.2% pre-WHI cohort v. 22.3% post-WHI cohort, p s (9.5% pre-WHI cohort v. 15.8% post-WHI cohort, p sion: The results of the WHI 2002 publication made an impression on the perception of HRT’s role in the relief of menopausal symptoms. Decision-making on the part of women seeking treatment for vasomotor symptoms and women’s health professionals demonstrates that despite HRT precautions, women continue to exhibit a need for HRT use. This study’s findings suggest that women seeking treatment for menopausal symptom relief and women’s health professionals continue to work together to find the appropriate balance between therapy use and adherence to therapy use guidelines.

关键词： Women’s Health Initiative (WHI) Hormone Replacement Therapy (HRT) Women’s Health Menopause

Genomic and genetic basisof seed nutritional content in Eragrostistef

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Genomic and genetic basisof seed nutritional content in Erag...

令医生大失所望的临床信息系统:超越现有技术的机遇

2015中国遗传学会大会

作者： Xuewen Wang Micai Zhon Meng Li srini Chaluvadi Katrien Devos Greg Ziegler Ivan Baxter Jeff Bennetzen Germplasm Bank of Wild species Kunming Institute of BotanyChinese Academy of Sciences Department of Genetics University of Georgia Department of Plant Biologyand Institute of Plant Breeding Genetics and Genomics(Department of Crop and Soil Sciences)University of Georgia

Tef(Eragrostistef),a tetraploid grass,is the mainstay of Ethiopian agriculture,with more acres planted than in any other *** has one of the bestmineral contentsamong cereals,with similarly high levels only found in another Chloridoid cereal,fiuger *** has high resilience to both drought and waterlogged soils,but its yield is low due to tiny seed size and severe susceptibility to *** have used mutational and other genetic approaches to investigate and help solve these *** is very high in protein and iron,and has more calcium than mother’s ***,we have generated the1st high density genetic map using sNPs in our newly developed genotype-by-sequencing *** new map has2002 sNP markers fora 145-RIL population,and generated 20 major linkage groups sorted into A andB genomes of this *** anchored more than 73%sequences of tef genomic contigs and scaffolds in the sNP genetic map,and more sequences after combining a ssR map,meaning an accomplishment of tef *** have used this map to identify QTL associated mineral content.A total of19 QTL were identified from the analysis of twenty minerals in ***-seqanalysis of developing seeds revealed QTL genes involved in nutritional *** combined with two full genome sequence analyses that have recently been completed,these analyses should undercover candidate genes associated with these traits,thus suggesting routes towards further nutritional improvement of tef and other cereals.

关键词： GBs ionomics mineral content QTL tef genomics

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中国数字医学 2009年第3期4卷 77-81页

作者： M. J. Ball J. s. silva s. Bierstock J. V. Douglas A. F. Norcio J. Chakraborty J. srini 张林（译） IBM医疗保健管理研究中心不详白求恩国际和平医院核医学科／PET中心河北省石家庄市中山西路398号050082

目的：旨在论述当前的临床信息系统为何惨遭失败。方法：对过去几十年临床信息系统的发展进行主观分析。结果与讨论：富有挑战性的难题就是预先考虑到临床医生们到底需要什么样的信息，继而专门针对他们的独特视角。为其提供这些信息。... 详细信息

目的：旨在论述当前的临床信息系统为何惨遭失败。方法：对过去几十年临床信息系统的发展进行主观分析。结果与讨论：富有挑战性的难题就是预先考虑到临床医生们到底需要什么样的信息，继而专门针对他们的独特视角。为其提供这些信息。临床医生需要的是那些能够提供由用户决定的。最大可能程度灵活性和用户化的工作站。我们设想并概括介绍了一种所谓的医疗服务点工作站。这种工作站能够在形形色色的医疗信息系统范围内，自动适应用户所需的显示方式、硬件能力、操作系统以及（本地或分布式的）应用程序。

关键词：临床工作站卫生专业人员工作站临床信息系统医疗信息系统

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毛囊接种鸡痘病毒疫苗鸡的免疫应答

动物医学进展 1990年第1期 39-39页

作者： D.K.serma s.N.sharma 章金钢

本文研究了5种不同的鸡痘病毒疫苗接种鸡的免疫应答。在这些鸡痘疫苗中,srini,BM和IVRI为印度市售株,另2株疫苗为西德的HP;鸡痘病毒株和在Punjab的一次鸡痘爆发时分离的地方株。所有疫苗毒株的滴度测定均在12日龄鸡胚的绒尿膜（CAM）上... 详细信息

本文研究了5种不同的鸡痘病毒疫苗接种鸡的免疫应答。在这些鸡痘疫苗中,srini,BM和IVRI为印度市售株,另2株疫苗为西德的HP;鸡痘病毒株和在Punjab的一次鸡痘爆发时分离的地方株。所有疫苗毒株的滴度测定均在12日龄鸡胚的绒尿膜（CAM）上进行。IVRI,BM和srini冻干

关键词：鸡痘病毒种鸡二次免疫滴度效价地方株鸡血清鸡群疫苗菌苗毛囊血凝性免疫应答