Induction of human dendritic cell maturation by naïve and memory B-cell subsets requires different activation stimuli

作     者：Mohan S.Maddur Srini V.Kaveri Jagadeesh Bayry 

作者机构：Institut National de la Santéet de la Recherche MédicaleParis F-75006France Centre de Recherche des CordeliersEquipeImmunopathologie et Immunointervention ThérapeutiqueParis F-75006France Sorbonne UniversitéParis F-75006France UniversitéParis DescartesSorbonne Paris CitéParis F-75006France Present address:PfizerInc.Pearl RiverNew YorkNYUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第12期

页      面：1074-1076页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Institut National de la Santé et de la Recherche Médicale (INSERM) Sorbonne Université and Université Paris Descartes  Paris  France 

主　　题：activation immune maturation 

摘      要：Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune *** outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation *** we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.