Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation
Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation作者机构：Institut National de la Sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France Sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris Descartes Paris France Department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et Service de Neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la Sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2015年第12卷第5期
页 面：650-652页
核心收录：
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 083203[工学-农产品加工及贮藏工程]
基 金：the Indian Institute of Science, the Department of Biotechnology, the Department of Science and Technology, Council for Scientific and Industrial Research (KNB) under grant agreement ALLFUN (JB) supported by the Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie, Universite Paris Descartes (SVK and JB) the Centre National de la Recherche Scientifique (SVK), the European Community's Seventh Framework Programme Cooperation INSERMICMR-AO 2009/2010(KNB and JB) fellowships from INSERMICMR,the Council for Scientific Industrial Research (JT) and Journees de Neurologie de Langue Francaise(MR)
主 题：DNA结合蛋白质类 地诺前列酮 抗原 CD4 免疫耐受 免疫球蛋白类 前列腺素内过氧化物合酶类 树突细胞 胰岛素 人类
摘 要：CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. Several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IVIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin E2 （PGE2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.
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