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Increased vitreal levels of interleukin-10 in diabetic retinopathy:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1477-1483页

作者： Wei Tan Jing-Ling Zou shigeo yoshida Bing Jiang Ye-Di Zhou Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic Disease Changsha 410011Hunan ProvinceChina Department of Ophthalmology Kurume University School of MedicineKurumeFukuoka 830-0011Japan

AIM:To conduct a Meta-analysis for the change of interleukin-10(I1-10)concentration in vitreous samples of patients with diabetic retinopathy(DR).METHODS:Systemic search for literature was conducted from the databases of PubMed,Web of Science and Cochrane Library by August *** analyses including standard mean difference(SMD)and its 95%confidence interval(CI)were performed by using RevMan 5.3 ***:Totally 194 studies were screened and finally 11 studies were included in the Meta-ana *** concentration of IL-10 in the DR group was higher than in the control group(P=***:0.77.95%CI:0.25-1.28).Significant heterogeneity was found among all studies(P<0.00001,I^2=92%).The subgroup analysis showed that the concentration of IL-10 increased in vitreous samples from patients with DR compared to the non-DR controls(P=***:1.44.95%CI:0.46-2.42).Moreover,the concentration of IL-10 in samples of proliferative diabetic retinopathy(PDR)patients was significantly higher than that of non-proliferative diabetic retinopathy(NPDR)patients(P=***:0.61.95%CI:0.13-1.08).CONCLUSION:The vitreal concentration of IL-10 is significantly increased in patients with *** studies are needed to reveal the mechanisms of IL-10 in DR.

关键词： diabetic retinopathy interleukin-10 Meta-analysis vitreal concentration

Diverse roles of macrophages in intraocular neovasculardiseases:a review

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1902-1908页

作者： Ye-Di Zhou shigeo yoshida Ying-Qian Peng Yoshiyuki Kobayashi Lu-Si Zhang Luo-Sheng Tang Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic Disease Changsha 410011Hunan ProvinceChina Department of Ophthalmology Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan

Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.

关键词： macrophage retinal neovascularization choroidal neovascularization proliferative diabetic retinopathy retinopathy ofprematurity age-related macular degeneration

Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 739-745页

作者： Lu-Si Zhang Ye-Di Zhou Ying-Qian Peng Hui-Lan Zeng shigeo yoshida Tan-Tai Zhao Department of Ophthalmology the Second Xiangya Hospital of Central South University Hunan Clinical Research Center of Ophthalmic Disease Department of Ophthalmology Kurume University School of Medicine

AIM: To identify disease-related miRNAs in retinas of mice with oxygen-induced retinopathy(OIR), and to explore their potential roles in retinal pathological neovascularization. METHODS: The retinal miRNA expression profile in mice with OIR and room air controls at postnatal day 17(P17) were determined through miRNA microarray analysis. Several miRNAs were significantly up-and down-regulated in retinas of mice with OIR compared to controls by quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR). Two databases including Targetscan7.1 and MirdbV5 were used to predict target genes that associated with those significantly altered mi RNAs in retinas of mice with OIR. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analyses were also conducted to identify possible biological functions of the target genes. RESULTS: In comparison with room air controls, 3 and 8 miRNAs were significantly up-and down-regulated, respectively, in retinas of mice with OIR. The qRT-PCR data confirmed that mmu-miR-350-3 p and mmu-miR-202-3 p were significantly up-regulated, while mmu-miR-711 and mmu-miR-30 c-1-3 p were significantly down-regulated in mice with OIR compared to controls. GO analysis demonstrated that the identified target genes were related to functions such as cellular macromolecule metabolic process. KEGG pathway analysis showed a group of pathways, such as Wnt signaling pathway, transcriptionalmisregulation in cancer, Mucin type O-glycan biosynthesis, and mitogen-activated protein kinase(MAPK) signaling pathway might be involved in pathological process of retinal neovascularization. CONCLUSION: Our findings suggest that the differentially expressed miRNAs in retinas of mice with OIR might provide potential therapeutic targets for treating retinal neovascularization.

关键词： microRNAs retinal neovascularization oxygen-induced retinopathy microarray

Role of interferons in diabetic retinopathy

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World Journal of Diabetes 2021年第7期12卷 939-953页

作者： Bing-Yan Li Wei Tan Jing-Ling Zou Yan He shigeo yoshida Bing Jiang Ye-Di Zhou Department of Ophthalmology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic Disease The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Ophthalmology Kurume University School of MedicineKurume 830-0011FukuokaJapan

Diabetic retinopathy(DR)is one of the major causes of visual impairment and irreversible blindness in developed *** from abnormal angiogenesis,inflammation is the most specific and might be the initiating factor of *** a key participant in inflammation,interferon-gamma(IFN-γ)can be detected in different parts of the eye and is responsible for the breakdown of the blood-retina barrier and activation of inflammatory cells and other cytokines,which accelerate neovascularization and neuroglial *** addition,IFN-γis involved in other vascular complications of diabetes mellitus and angiogenesis-dependent diseases,such as diabetic nephropathy,cerebral microbleeds,and age-related macular *** treatments,such as anti-vascular endothelial growth factor agents,vitrectomy,and laser photocoagulation therapy,are more effective for angiogenesis and not tolerable for every *** ongoing clinical trials are exploring effective drugs that target *** instance,IFN-αacts against viruses and angiogenesis and is commonly used to treat malignant ***,IFN-αhas been shown to contribute to alleviating the progression of DR and other ocular *** this review,we emphasize the roles that IFNs play in the pathogenesis of DR and discuss potential clinical applications of IFNs in DR,such as diagnosis,prognosis,and therapeutic treatment.

关键词： Interferons Cytokines Diabetic retinopathy Interferon-alpha Interferongamma Inflammation

Attenuation of periostin in retinal Müller glia by TNF-α and IFN-γ

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 212-218页

作者： Ying-Qian Peng Man-Jing Cao shigeo yoshida Lu-Si Zhang Hui-Lan Zeng Jing-Ling Zou Yoshiyuki Kobayashi Takahito Nakama Jing-Ming Shi Song-Bai Jia Ye-Di Zhou Department of Ophthalmology the Second Xiangya Hospital Central South University Hunan Clinical Research Center of Ophthalmic Disease Department of Ophthalmology Kyushu University Graduate School of Medical Sciences Department of Ophthalmology Kurume University School of Medicine

AIM: To investigate the regulation and mechanisms of periostin expression in retinal Müller glia, and to explore the relevance to retinal neovascularization. METHODS: The oxygen-induced retinopathy(OIR) mouse model and the human Moorfield/Institute of Ophthalmology-Müller 1(MIO-M1) cell line were used in the study. Immunofluorescence staining was used to determine the distribution and expression of periostin and a Müller glial cell marker glutamine synthetase(GS). Cytokines TNF-α and IFN-γ were added to stimulate the MIO-M1 cells. ShRNA was used to knockdown periostin expression in MIO-M1 cells. Quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR) was conducted to assess the mRNA expression of periostin. RESULTS: Immunofluorescence staining showed that periostin was expressed by MIO-M1 Müller glia. GS-positive Müller glia and periostin increased in OIR retinas, and were partially overlaid. The stimulation of TNF-α and IFN-γ reduced the mRNA expression of periostin significantly and dose-dependently in MIO-M1 cells. Knockdown of periostin reduced mRNA expression of vascular endothelial growth factor A(VEGFA) in MIO-M1 cells, while VEGFA expression was not changed in periostin knock-out OIR retinas. CONCLUSION: Müller glia could be one of the main sources of periostin in the retina, and might contribute to the pathogenesis of retinal neovascularization. Proinflammatory cytokines TNF-α and IFN-γ attenuate the periostin expression in retinal Müller glia, which provides a potential and novel method in treating retinal neovascular diseases.

关键词： TNF-α IFN-γ periostin Müller glia retinal neovascularization

Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2005年第1期11卷 89-93页

作者： Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa yoshida Shoji Mitsufuji Kazuhiro Nishida shigeo Horiike shigeo Nakamura Masuji Morita Masafumi Taniwaki Molecular Gastroenterology and Hepatology Molecular Hematology and Oncology Department of Internal Medicine Department of Pathology and Clinical Laboratories School of Nursing Clinical Molecular Genetics and Laboratory Medicine

AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of ***: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of ***: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma.

关键词： Helicobacter pylori infection Gastric MALT lymphoma Trisomy 3

Measurement Method of Internal Residual Stress in Plastic Parts Using Terahertz Spectroscopy

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Nanomanufacturing and Metrology 2021年第1期4卷 46-52页

作者： Yusuke Kajihara Rio Takahashi Ichiro yoshida Shingo Saito Norihiko Sekine Shuichi Nowatari shigeo Miyake Institute of Industrial Science The University of TokyoKomaba 4-6-K Meguro-kuTokyoJapan Hosei University Kajino 3-7-2.KoganeiTokyoJapan National Institute of Information and Communications Technology Nukui-Kitamachi 4-2-1KoganeiTokyoJapan Iida Co. LtdNukazawa Mizukami 21-2MotomiyiaFukushimaJapan

Since internal residual stress in polymers causes dimension errors over time,a measurement method for residual stress in polymers,especially in opaque engineering plastics,is strongly *** this study,we propose to utilize terahertz(THz)spectroscopy to non-destructively measure internal residual stress in *** verify the validity of the proposed method,we manufactured polytetrafluoroethylene ring samples with and without residual stress,and studied them with THz time domain spectroscopy *** spectra of samples without residual stress showed almost no polarization difference,whereas spectra of samples with residual stress showed clear polarization *** changes between the samples with and without residual stress were also estimated and it was found that the change had a correlation with THz polarization *** experimental analyses confirm the validity for the proposed non-destructive measurement of residual stress in polymer.

关键词： Engineering plastics Residual stress Polarization Terahertz spectroscopy

Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma

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World Journal of Gastroenterology 2005年第17期11卷 2681-2683页

作者： Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda shigeo Horiike Takeshi Okanoue Masafumi Taniwaki Department of Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Inflammation and Immunology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Division of Digestive Surgery Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Clinical Molecular Genetics and Laboratory MedicineKyoto Prefectural University of MedicineGraduate School of Medical ScienceKyotoJapan

Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases.

关键词： Pseudomembranous colitis Ileus Vancomycin Chemotherapy Lymphoma

Successful endoscopic hemostasis for gastric arterial bleeding due to invasion of malignant lymphoma

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World Journal of Gastroenterology 2005年第27期11卷 4285-4286页

作者： Kenichi Nomura Shinya Yamada Daisuke Shimizu Takashi Okuda Yuri Kamitsuji Naohisa yoshida Yosuke Matsumoto Naoki Wakabayashi Kazuya Mikami shigeo Horiike Takeshi Okanoue Masafumi Taniwaki Masafumi Taniwaki Molecular Gastroenterology and Hepatology Department of Urology Clinical Molecular Genetics and Laboratory Medicine

A 75-year-old male with malignant lymphoma (ML) accompanied with gastric lesion was treated with combination chemotherapy. The patient produced tarry stool on the 4th d, and emergency gastroscopy showed arterial bleeding from the lesion. Hemostasis was achieved by injecting pure ethanol and using hemostatic clips. There is only one previous report on endoscopic hemostasis being effective for bleeding due to lymphoma. Since gastric bleeding causes significant mortality, endoscopic hemostasis should be considered as first-line treatment for ML patients who were treated with chemotherapy.

关键词： Malignant lymphoma Endoscopic hemostasis Pure ethanol injection Hemostatic clips