Role of interferons in diabetic retinopathy
作者机构：Department of OphthalmologyThe Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic DiseaseThe Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of OphthalmologyKurume University School of MedicineKurume 830-0011FukuokaJapan
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2021年第12卷第7期
页 面：939-953页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.81800855 and No.82070967 Natural Science Foundation of Hunan Province,No.2018JJ3765
主 题：Interferons Cytokines Diabetic retinopathy Interferon-alpha Interferongamma Inflammation
摘 要：Diabetic retinopathy(DR)is one of the major causes of visual impairment and irreversible blindness in developed *** from abnormal angiogenesis,inflammation is the most specific and might be the initiating factor of *** a key participant in inflammation,interferon-gamma(IFN-γ)can be detected in different parts of the eye and is responsible for the breakdown of the blood-retina barrier and activation of inflammatory cells and other cytokines,which accelerate neovascularization and neuroglial *** addition,IFN-γis involved in other vascular complications of diabetes mellitus and angiogenesis-dependent diseases,such as diabetic nephropathy,cerebral microbleeds,and age-related macular *** treatments,such as anti-vascular endothelial growth factor agents,vitrectomy,and laser photocoagulation therapy,are more effective for angiogenesis and not tolerable for every *** ongoing clinical trials are exploring effective drugs that target *** instance,IFN-αacts against viruses and angiogenesis and is commonly used to treat malignant ***,IFN-αhas been shown to contribute to alleviating the progression of DR and other ocular *** this review,we emphasize the roles that IFNs play in the pathogenesis of DR and discuss potential clinical applications of IFNs in DR,such as diagnosis,prognosis,and therapeutic treatment.
维普期刊数据库