Increased vitreal levels of interleukin-10 in diabetic retinopathy:a Meta-analysis
作者机构：Department of Ophthalmologythe Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic DiseaseChangsha 410011Hunan ProvinceChina Department of OphthalmologyKurume University School of MedicineKurumeFukuoka 830-0011Japan
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2020年第13卷第9期
页 面：1477-1483页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by National Natural Science Foundation of China(No.81800855,No.81770930) Natural Science Foundation of Hunan Province(No.2018JJ3765) Changsha Science and Technology Project(No.kq1907075) Department of Science and Technology,Hunan(No.2015TP2007)
主 题：diabetic retinopathy interleukin-10 Meta-analysis vitreal concentration
摘 要：AIM:To conduct a Meta-analysis for the change of interleukin-10(I1-10)concentration in vitreous samples of patients with diabetic retinopathy(DR).METHODS:Systemic search for literature was conducted from the databases of PubMed,Web of Science and Cochrane Library by August *** analyses including standard mean difference(SMD)and its 95%confidence interval(CI)were performed by using RevMan 5.3 ***:Totally 194 studies were screened and finally 11 studies were included in the Meta-ana *** concentration of IL-10 in the DR group was higher than in the control group(P=***:0.77.95%CI:0.25-1.28).Significant heterogeneity was found among all studies(P0.00001,I^2=92%).The subgroup analysis showed that the concentration of IL-10 increased in vitreous samples from patients with DR compared to the non-DR controls(P=***:1.44.95%CI:0.46-2.42).Moreover,the concentration of IL-10 in samples of proliferative diabetic retinopathy(PDR)patients was significantly higher than that of non-proliferative diabetic retinopathy(NPDR)patients(P=***:0.61.95%CI:0.13-1.08).CONCLUSION:The vitreal concentration of IL-10 is significantly increased in patients with *** studies are needed to reveal the mechanisms of IL-10 in DR.
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