Diverse roles of macrophages in intraocular neovasculardiseases:a review
Diverse roles of macrophages in intraocular neovascular diseases:a review作者机构：Department of Ophthalmologythe Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic DiseaseChangsha 410011Hunan ProvinceChina Department of OphthalmologyKyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2017年第10卷第12期
页 面：1902-1908页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：Supported by National Natural Science Foundation of China(No.81371036 No.81700837) Department of Science and Technology,Hunan(No.2015TP2007) Japan Society for the Promotion of Science KAKENHI Grants(No.26293374 No.16K15734)
主 题：macrophage retinal neovascularization choroidal neovascularization proliferative diabetic retinopathy retinopathy ofprematurity age-related macular degeneration
摘 要：Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
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