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Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut EA Lundin Ciaran P Kelly David S Sanders Kristina Chen sheena kayaniyil Sisi Wang Rajvi J Wani Caitlin Barrett Shakira Yoosuf Ellen S Pettersen Robert Sambrook Daniel A Leffler K.G.Jebsen Coeliac Disease Research Centre University of OsloOslo 0450Norway Department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel Deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence Strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence Strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUND Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United States,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before December 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of December 31,2017).RESULTS A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(SD)17.2].Patients were followed-up for a mean of 29.9 mo(SD 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in Norway and patients in the United States had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

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Fast and Efficient Security Scheme for Blockchain-Based IoT Networks

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Computers, Materials & Continua 2022年第10期73卷 2097-2114页

作者： K.A.Fasila sheena Mathew School of Engineering Cochin University of Science and TechnologyKeralaIndia

Internet of Things(IoT)has become widely used nowadays and tremendous increase in the number of users raises its security requirements as *** constraints on resources such as low computational capabilities and power requirements demand lightweight *** algorithms are not applicable in IoT network communications because of the constraints mentioned *** this work,a novel and efficient scheme for providing security in IoT applications is *** scheme proposes how security can be enhanced in a distributed IoT application by providing multilevel protection and dynamic key generation in the data uploading and transfer *** works rely on a single key for communication between sensing device and the attached gateway *** proposed scheme,this session key is updated after each session and this is done by applying principles of cellular *** proposed system provides multilevel security by using incomparable benefits of blockchain,dynamic key and random number generation based on cellular *** same was implemented and tested with the widely known security protocol verification tool called Automated Validation of Internet Security Protocols and Applications(AVISPA).Results show that the scheme is secure against various *** proposed scheme has been compared with related schemes and the result analysis shows that the new scheme is fast and efficient also.

关键词： Cellular automata based key generation dynamic key generation IoT security No-share key Exchange blockchain for IoT mutual authentication

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Multispectral imaging of acute wound tissue oxygenation

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Journal of Innovative Optical Health Sciences 2017年第3期10卷 89-96页

作者： Audrey Huong sheena Philimon Xavier Ngu Department of Electronic Engineering Faculty of Electrical and Electronic Engineering University Tun Hussein Onn Malaysia Batu Pahat 86400 JohorMalaysia

This paper investigates the appropriate range of values for the transcutaneous blood oxygen saturation(StO2)of granulating tissues and the surrounding tissue that can ensure timely wound *** work has used a multispectral imaging system to collect wound images at wave-lengths ranging between 520 nm and 600 nm with a resolution of 10 *** part of this research,a pilot study was conducted on three injured individuals with superfcial wounds of different wound ages at different skin *** S_(t)O_(2)value predicted for the examined wounds using the Extended Modified Lambert-Beer model revealed a mean S_(t)O_(2)of 61±10.3%compared to 41.6±6.2%at the surrounding tissues,and 50.1±1.53%for control *** preliminary results contribute to the existing knowledge on the possible range and variation of wound bed S_(t)O_(2)that are to be used as indicators of the functioning of the vasomotion system and wound *** study has concluded that a high S_(t)O_(2)of approximately 60%and a large fuctuation in this value should precede a good progression in wound healing.

关键词： Multispectral imaging wound healing transcutaneous blood oxygen saturation extended modified Lambert-Beer.

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Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis Overlap Syndrome:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 336-346页

作者： sheena Mago George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Primary sclerosing cholangitis(PSC)and primary biliary cirrhosis(PBC)are slow progressive diseases which have been increasing in *** pathogeneses of PBC and PSC are incompletely understood but the underlying mechanisms appear to be fundamentally autoimmune in *** PBC and PSC appear to be separate entities,overlap has been *** depends on a combination of serological markers,imaging,and pathological *** mainstay of treatment has been ursodeoxycholic acid and in some cases of extrahepatic biliary obstruction and overlap disorder,endoscopic retrograde cholangiopancreatography has been useful.

关键词： Primary sclerosing cholangitis Primary biliary cirrhosis Overlap syndrome

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When to pull the trigger in nonazoospermic infertile men undergoing intracytoplasmic sperm injection?

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Asian Journal of Andrology 2020年第4期22卷 439-440页

作者： Sandro C Esteves sheena EM Lewis ANDROFERT Andrology and Human Reproduction ClinicReferral Center for Male Reproduction13075-460 CampinasSPBrazil Department of Surgery(Division of Urology) University of Campinas(UNICAMP)13083-887 CampinasSPBrazil Faculty of Health Aarhus University8000 AarhusDenmark Queens University Belfast Northern Ireland BT71NNUK Examenlab Ltd. Weavers Court Business ParkLinfield RoadBelfastNorthern Ireland BT125GHUK

Before the era of intracytoplasmic sperm injection(ICSI),few options were available for men with severe infertility to father a biological *** in 1992 as a modification of conventional in vitro fertilization,ICSI has enabled men with low sperm quantity and quality to have their own biological offspring.[1]Among nonazoospermic infertile men,ICSI has been traditionally carried out with ejaculated *** contrast,methods to harvest sperm from the epididymides and testes are used for ICSI in men with azoospermia-related infertility.

关键词： injection infertility traditionally

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An efficient permutation approach for SbPN-based symmetric block ciphers

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Cybersecurity 2024年第2期7卷 113-130页

作者： Mir Nazish M.Tariq Banday Insha Syed sheena Banday Department of Electronics and Instrumentation Technology University ofKashmirSrinagar 190006India

It is challenging to devise lightweight cryptographic primitives efficient in both hardware and software that can provide an optimum level of security to diverse Internet of Things applications running on low-end constrained ***,an effcient hardware design approach that requires some specific hardware resource may not be effcient if implemented in *** bit Permutation Network based ciphers such as PRESENT and GIFT are effcient,lightweight cryptographic hardware design *** ciphers introduce confusion and diffu-sion by employing a 4×4 static substitution box and bit *** bit-wise permutation is realised by sim-ple rerouting,which is most cost-effective to implement in hardware,resulting in negligible power ***,this method is highly resource-consuming in software,particularly for large block-sized ciphers,with each single-bit permutation requiring multiple *** paper proposes a novel software-based design approach for permutation operation in Substitution bit Permutation Network based ciphers using a bit-banding *** conventional permutation using bit rotation and the proposed approach have been implemented,analysed and compared for GIFT and PRESENT ciphers on ARM Cortex-M3-based LPC1768 development platform with KEIL MDK used as an Integrated Development *** real-time performance comparison between conven-tional and the proposed approaches in terms of memory(RAM/ROM)footprint,power,energy and execution time has been carried out using ULINKpro and ULINKplus debug adapters for various code and speed optimisation *** proposed approach substantially reduces execution time,energy and power consumption for both PRE-SENT and GIFT ciphers,thus demonstrating the effciency of the proposed method for Substitution bit Permutation Network based symmetric block ciphers.

关键词： Lightweight cryptography PRESENT GIFT SbPN Cortex-M LPC1768 Bit-band memory

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Microalgal bioinoculants for sustainable agriculture and their interactions with soil biotic and abiotic components:A review

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Pedosphere 2024年第2期34卷 297-314页

作者： Shisy JOSE Nirmal RENUKA Sachitra Kumar RATHA sheena KUMARI Faizal BUX Institute for Water and Wastewater Technology Durban University of TechnologyP.O.Box 1334Durban 4000South Africa Algal Biotechnology Laboratory Department of BotanyCentral University of PunjabBathinda 151401India Phycology Laboratory Council of Scientific and Industrial Research-National Botanical Research InstituteLucknowUttar Pradesh 226001India

Modern agricultural practices have posed a detrimental impact on the environment due to their intensive use to meet the food demands of an ever-increasing *** this context,microalgal bioinoculants,specifically cyanobacteria and green microalgae,have emerged as sustainable options for agricultural practices to improve soil organic carbon,nutrient availability,microbial quality,and plant *** overview of current and future perspectives on the use of microalgal bioinoculants in agriculture practices is presented in this review,along with a discussion of their interactions with soil biotic and abiotic factors that affect soil fertility,plant health,and crop *** benefits of microalgal bioinoculants include releasing agronomically important metabolites(exopolymers and phytohormones)as well as solubilizing soil ***,they function as biocontrol agents against soil-borne pathogens and facilitate the establishment of rhizosphere communities of agricultural *** far,very few studies have explored the basic mechanisms by which microalgal bioinoculants interact with soil biotic and abiotic *** recent years,advanced molecular techniques have contributed to a better understanding of these interactions.

关键词： biocontrol agent biofertilizer cyanobacteria microalgae microbial community molecular technique plant growth soil fertility

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Landscape Characterization of Sariska National Park (India) and Its Surroundings

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Geo-Spatial Information Science 2011年第4期14卷 303-310页

作者： JOSHI Pawan Kumar NARULA sheena RAWAT Asha GHOSH Aniruddha Department of Natural Resources TERI University

Landscape characterization gives an overall information on the status of Land Use and Land Cover （LULC）, changes in its composition and the impact of natural and human influences operating at different spatial and temporal scales. This information can be used to monitor changes in natural forest resources and protected areas, delineate potential conservation areas and can serve in effective management of ecologically fragile landscapes. In the present study, geo-spatial tools were used to characterize the landscape of Sariska National Park and its surroundings. Satellite data was used to prepare LULC maps for 1989 and 2000, change detection analysis and computation of landscape metrics. Climatic data, field records and modeling tools were used to map the potential spread of two invasive species, Prosopis juliflora and Adhatoda vasica. The results show that the forest area increased from 1989 to 2000, indicating better management practices. Landscape metrics （PAFRAC, PLADJ and AI） also support this argument. Improvements in the degraded forest can further enhance this effect. The entire reserve however is suitable for the invasion of P. juliflora and A. vasiea but is more pronounced in Boswellia serrata and Anogeissus pendula - Acacia catechu （open） forests. A detailed landscape characterization map can help forest managers to make important policy decisions concerning issues such as invasive species.

关键词： image geo-spatial tools invasion landscape analysis vegetation LULC

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An Ontology Based Multilayer Perceptron for Object Detection

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Computer Systems Science & Engineering 2023年第3期44卷 2065-2080页

作者： P.D.sheena Smart K.K.Thanammal S.S.Sujatha Department of Computer Science S.T.Hindu CollegeNagercoilAffiliated to Manonmaniam Sundaranar UniversityAbishekapattiTirunelveli627012TamilnaduIndia Department of Computer Science and Applications S.T.Hindu CollegeNagercoil629002India

In object detection,spatial knowledge assisted systems are *** detection is a main and challenging issue to analyze object-related *** existing object detection techniques were developed to consider the object detection problem as a classification problem to perform feature selection and *** these techniques still face,less computational efficiency and high time *** paper resolves the above limitations using the Fuzzy Tversky index Ontology-based Multi-Layer Perception method which improves the accuracy of object detection with minimum *** proposed method uses a multilayer forfinding the similarity score.A fuzzy membership function is used to validate the score for predicting the burned and non-burned *** assessment is performed with different factors such as classification rate,time complexity,error rate,space complexity,and precision by using the forestfire *** results show that this novel technique can help to improve the classification rate and reduce the time and space complexity as well as error rate than the conventional methods.

关键词： Object detection similarity score ontology deep learning fuzzy function perception

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The paternal genome and the health of the assistect reproductive technology child

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Asian Journal of Andrology 2015年第4期17卷 616-622页

作者： sheena EM Lewis Kishlay Kumar Centre for Public Health Queen's University Belfast Grosvenor Road BT12 6BJNI UK.

As a number of children born by assisted reproductive technology （ART） are increasing each year across the developed world, the health of such offspring is a matter of public concern. Does the integrity of the paternal genome impact on offspring health？ In societal terms, as birth rates fall, and the Western population become unsustainable, do the benefits outweigh the costs of creating and providing for this ART conceived subpopulation？ There are little data to date to answer these questions. The long-term health of such children has largely been ignored, and success measured only by early （prebirth） outcomes such as embryo quality or pregnancy. However, there are powerful paradigms such as ageing and smoking that give vital clues as to the potential impact of unhealthy spermatozoa on disease risk, mental and physical health, fertility and mortality of these offspring.

关键词： sperm DNA damage paternal genome offspring infertility

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