The paternal genome and the health of the assistect reproductive technology child

作     者：Sheena EM Lewis Kishlay Kumar 

作者机构：Centre for Public Health Queen's University Belfast Grosvenor Road BT12 6BJNI UK. 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2015年第17卷第4期

页      面：616-622页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 08[工学] 09[农学] 090501[农学-动物遗传育种与繁殖] 10[医学] 

主　　题：sperm DNA damage paternal genome offspring infertility 

摘      要：As a number of children born by assisted reproductive technology （ART） are increasing each year across the developed world, the health of such offspring is a matter of public concern. Does the integrity of the paternal genome impact on offspring health？ In societal terms, as birth rates fall, and the Western population become unsustainable, do the benefits outweigh the costs of creating and providing for this ART conceived subpopulation？ There are little data to date to answer these questions. The long-term health of such children has largely been ignored, and success measured only by early （prebirth） outcomes such as embryo quality or pregnancy. However, there are powerful paradigms such as ageing and smoking that give vital clues as to the potential impact of unhealthy spermatozoa on disease risk, mental and physical health, fertility and mortality of these offspring.