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Strategies and challenges in the treatment of chronic venous leg ulcers

World Journal of Clinical Cases 2020年第21期8卷 5070-5085页

作者： Shi-yan Ren Yong-Sheng Liu Guo-jian zhu Meng Liu shao-Hui Shi Xiao-Dong Ren Ya-Guang Hao Rong-Ding Gao Department of General Surgery and Vascular Surgery Aviation General HospitalChina Medical UniversityBeijing 100012China Department of Dermatology Aviation General HospitalBeijing 100012China Department of General Surgery Taian Communications HospitalTaian 271000Shandong ProvinceChina Department of Surgery Tianjin Hexi HospitalTianjin 300202TianjinChina Department of Orthopaedic Surgery Aviation General HospitalChina Medical UniversityBeijing 100012China Department of Surgery Wanquanqu Zhongyi HospitalZhangjiakou 076250Hebei ProvinceChina Department of Medical Administrative Aviation General HospitalChina Medical UniversityBeijing 100012China Department of General Surgery Aviation General HospitalChina Medical UniversityBeijing 100012China

Evaluating patients with chronic venous leg ulcers(CVLUs)is essential to find the underlying *** basic tenets in managing CVLUs are to remove the etiological causes,to address systemic and metabolic conditions,to examine the ulcers and artery pulses,and to control wound infection with debridement and eliminating excessive pressure on the *** first-line treatments of CVLUs remain wound care,debridement,bed rest with leg elevation,and *** to support the efficacy of silver-based dressings in healing CVLUs is *** peroxide is harmful to the growth of granulation tissue in the *** options include a high ligation with or without stripping or ablation of the GSVs depending on venous reflux or ***,not all CVLUs are candidates for surgical treatment because of *** standard care of wound for 4 wk failed to heal CVLUs effectively,use of advanced wound care should be considered based on the available *** pressure wound therapy facilitates granulation tissue development,thereby helping closure of *** split-thickness skin grafting is still the gold standard approach to close huge *** punch graft appears to have a better result than traditional hairless punch graft for *** of adipose tissue or placenta-derived mesenchymal stem cells is a promising therapy for wound *** platelet-rich plasma provides an alternative strategy for surgery for safe and natural healing of the *** confirmative efficacy of current advanced ulcer therapies needs more robust evidence.

关键词： Chronic venous leg ulcers Debridement Compression Negative pressure wound therapy Autologous split-thickness skin grafting Hair punch graft Platelet-rich plasma Advanced wound care therapies

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Prognostic significance of multiple triglycerides-derived metabolic indices in patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2022年第6期19卷 456-468页

作者： Qiao-Yu shao Xiao-Teng ma Zhi-Qiang yanG qiu-Xuan LI Yu-Fei WANG Jing LIANG Hua SHEN Xiao-Li LIU Yu-Jie ZHOU Dong-Mei SHI Zhi-jian WANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Triglyceride(TG)and its related metabolic indices,all recognized as surrogates of insulin resistance,have been demonstrated to be relevant to clinical ***,the relative value of these TG-related indices for predicting cardiovascular events among patients with acute coronary syndrome(ACS)has not been *** The TG,the triglyceride-glucose(TyG)index,the atherogenic index of plasma,TG to high-density lipoprotein cholesterol ratio,and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary *** primary endpoint was major adverse cardiovascular event(maCE),which was the composite of all-cause mortality,stroke,myocardial infarction,or unplanned repeat *** During a median follow-up of 31 months,345 patients(20.4%)had *** risk of the maCE was increased with higher TG and the four TG-derived metabolic indices[TG-adjusted hazard ratio(HR)=1.002,95%CI:1.001-1.003;TyG index-adjusted HR=1.736,95%CI:1.398-2.156;atherogenic index of plasma-adjusted HR=2.513,95%CI:1.562-4.043;TG to high-density lipoprotein cholesterol ratio-adjusted HR=1.148,95%CI:1.048-1.258;and lipoprotein combine index-adjusted HR=1.009,95%CI:1.004-1.014;PmaCE in addition to the baseline *** them,TyG index showed the best ability for predicting maCE compared with the other three indices from all the three measurements(PmaCE among ACS patients undergoing percutaneous coronary *** all the indices,TyG index showed the best ability to predict the risk of maCE.

关键词： patients coronary indices

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Any-polar resistive switching behavior in Ti-intercalated Pt/Ti/HfO_(2)/Ti/Pt device

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Chinese Physics B 2021年第11期30卷 656-660页

作者： Jin-Long Jiao qiu-Hong Gan Shi Cheng Ye Liao shao-Ying Ke Wei Huang jian-Yuan Wang Cheng Li Song-yan Chen Department of Physics and Jiujiang Research Institute Xiamen UniversityXiamen 361005China College of Physics and Information Engineering Minnan Normal UniversityZhangzhou 363000China

The special any-polar resistive switching mode includes the coexistence and stable conversion between the unipolar and the bipolar resistive switching mode under the same compliance *** the present work,the any-polar resistive switching mode is demonstrated when thin Ti intercalations are introduced into both sides of Pt/HfO_(2)/Pt RRAM *** role of the Ti intercalations contributes to the fulfillment of the any-polar resistive switching working mechanism,which lies in the filament constructed by the oxygen vacancies and the effective storage of the oxygen ion at both sides of the electrode interface.

关键词： filament memory resistive switching

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Characterization of Reaction of Primary Amine WithDiketones in Aqueous Solution

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光谱学与光谱分析 2020年第S1期40卷 245-246页

作者： zhu Qing ZONG Su-san LUO yan Tony Tang CHEN Xiao-yun William Wang Sam qiu FENG shao-guang Dow Chemical Company Core R&DShanghai 201203China The Dow Chemical Company Core R&D Analytical SciencesMidlandMI 48674USA

In this study,the interaction between primary amine and diketones was *** diketones with a general structure of—(CH2C(O)CH2C(O))-X-R(X is C,O or N and R is H and/or alkyl groups)were selected to react with primary amine in aqueous *** reaction was in-situ monitored by Raman technique and the reaction products were identified by FTIR,NMR and *** is found that the reaction products strongly depend on the structures of *** X is nitrogen,the expected Schiff base or its analog can be ***,Schiff base or its analog is not detected if X is C or O,instead,ion pairs or hydrolysis products are formed accordingly,suggesting critical impacts of acidity of CH2 inβ-diketone on the product *** study also shows that in-situ Raman is a powerful technique for reaction monitoring and structure characterization,which is useful for mechanism understanding.

关键词： Amine Diketone In-situ Raman Reaction monitoring

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The integrative analysis of microRNA and mRNA expression in Apis mellifera following maze-based visual pattern learning

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Insect Science 2014年第5期21卷 619-636页

作者： qiu-Hong Qin Zi-Long Wang Liu-Qing Tian Hai-yan Gan shao-Wu Zhang Zhi-jiang Zeng Honeybee Research Institute Jiangxi Agricultural University Nanchang China ARC Center of Excellence in Vision Science Research School of Biology The Australian National University Canberra ACT Australia

The honeybee （Apis mellifera） is a social insect with strong sensory capacity and diverse behavioral repertoire and is recognized as a good model organism for studying the neurobiological basis of learning and memory. In this study, we analyzed the changes in microRNA （miRNA） and messenger RNA （mRNA） following maze-based visual learning using next-generation small RNA sequencing and Solexa/lllumina Digital Gene Expression tag profiling （DGE）. For small RNA sequencing, we obtained 13 367 770 and 13 132 655 clean tags from the maze and control groups, respectively. A total of 40 differentially expressed known miRNAs were detected between these two samples, and all of them were up-regulated in the maze group compared to the control group. For DGE, 5 681 320 and 5 939 855 clean tags were detected from the maze and control groups, respectively. There were a total of 388 differentially expressed genes between these two samples, with 45 genes up-regulated and 343 genes down-regulated in the maze group, compared to the control group. Additionally, the expression levels of 10 differentially expressed genes were confirmed by quantitative reverse transcription polymerase chain reaction （qRT-PCR） and the expression trends of eight of them were consistent with the DGE result, although the degree of change was lower in amplitude. The integrative analysis of miRNA and mRNA expression showed that, among the 40 differentially expressed known miRNAs and 388 differentially expressed genes, 60 pairs of miRNA/mRNA were identified as co-expressed in our present study. These results suggest that both miRNA and mRNA may play a pivotal role in the process of learning and memory in honeybees. Our sequencing data provide comprehensive miRNA and gene expression information for maze-based visual learning, which will facilitate understanding of the molecular mechanisms of honeybee learning and memory.

关键词： Apis mellifera Y-maze learning and memory microRNA DGE differential expression

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Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients:A Multi-Center,Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第10期27卷 729-736页

作者： GUO Jie-mei XIAO yan CAI Tang-yan WANG jian-hui LI Bao-lin HUANG Lu-lu maO Xiao LAI Xing-quan zhu Ya-ju ZHANG Yi-qiang CHEN shao-qing SU You-xin Department of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou(350122)China Department of Clinical Medicine Fujian Health CollegeFuzhou(350101)China Department of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou(350122)China Department of Rehabilitation Fujian Tingzhou HospitalLongyanFujian Province(366300)China Department of Emergency Xiaogan Chinese Medicine HospitalXiaoganHubei Province(432100)China Department of Rehabilitation Fuzhou First HospitalFuzhou(350009)China Fujian University of Traditional Chinese Medicine Fuzhou(350122)China

Objective:To determine the effects of Chinese medicine(CM)involving triple rehabilitation therapy on the progression of knee osteoarthritis(KOA).Methods:A total of 722 patients recruited from 38 community health service centers located in China from march 2013 to march 2017 were randomly divided into treatment and control groups equally,using a cluster randomization *** education combined with CM involving triple rehabilitation therapy for KOA(electro-acupuncture,Chinese medicinal herb fumigating-washing,and traditional exercises)was administered in the treatment group while conventional rehabilitation therapy(physical factor therapy,joint movement training,and muscle strength training)was administered in the control *** with a visual analog scale(VAS)scores>A were treated with dispersible meloxicam tablets(7.5 mg,once daily).The Lequesne index scores,VAS scores,range of motion(ROM),lower limb muscle strength,knee joint circumference,quantitative scores of KOA symptoms,and the short-form 36 item health survey questionnaire(SF-36)scores were measured for each patient at 5 checkpoints(before treatment,at the 2nd week and the 4th week during the 4-week treatment period,at 1 month and 3 months after end of treatment),and adverse reactions were observed ***:A total of 696 patients completed the entire process,with 351 in the treatment group and 345 in the control *** all treatment checkpoints,the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores,effective rate and improvement rate of the total Lequesne index scores,VAS scores,lower limb muscle strength,knee circumference,quantitative scores of KOA symptoms,and SF-36 scores as well(P<0.05 or P<0.01).No adverse reactions were encountered in this ***:CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling,improve lower limb muscle strength,promote flexion and activity of the knee a

关键词： knee osteoarthritis Chinese medicine involving triple rehabilitation therapy electro-acupuncture Chinese medicinal herb fumigating-washing traditional exercises community rehabilitation

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A Global Multiregional Proteomic map of the Human Cerebral Cortex

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 614-632页

作者： Zhengguang Guo Chen shao yang Zhang Wenying qiu Wenting Li Weimin zhu Qian yang Yin Huang Lili Pan Yuepan Dong Haidan Sun Xiaoping Xiao Wei Sun Chao ma Liwei Zhang Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Department of Neurosurgery China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Human Anatomy Histologyand EmbryologyInstitute of Basic Medical SciencesNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China

The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains *** present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 *** 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca’s area cluster,Wernicke’s area cluster,cingulate cortex cluster,and heterogeneous function *** identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding cluster or *** findings of the present study could provide explanations for the functional connections between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor *** brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different *** proteomic data are publicly available at the Human Brain Proteome Atlas(***).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.

关键词： Brodmann area Proteomics Cerebral cortex Cingulate cortex Sensorimotor cortex

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Peripheral monocyte count： an independent diagnostic and prognostic biomarker for prostate cancer - a large Chinese cohort study

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Asian Journal of Andrology 2017年第5期19卷 579-585页

作者： yan-Qing Wang Yin-Jie zhu Jia-Hua Pan Fan Xu Xiao-Guang shao jian-Jun Sha Qiang Liu Yi-Ran Huang Bai-Jun Dong Wei Xue Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Pathology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Increasing evidence indicates that inflammation may play important roles in tumorigenesis and progression, and an elevated peripheral monocyte count predicts a poor prognosis in various types of malignancies. Here, we evaluate the roles of peripheral monocyte count in the diagnosis and prognosis for prostate cancer in Chinese patients. A total of 1107 consecutive patients who had undergone prostate biopsy and 290 prostate cancer patients receiving androgen deprivation therapy as first-line therapy were retrospectively analyzed. The parameters were measured at the time of diagnosis. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of a positive biopsy. Patients were categorized in two groups using a cutoff point of 0.425 x 109 1-1 as calculated by the receiver-operating curve analysis for prognosis. Univariate and multivariate Cox regression analyses were performed to determine the associations of monocyte count with progression-free survival, cancer-specific survival, and overall survival. Multivariate logistic regression analyses showed that monocyte count, age, prostate-specific antigen （PSA）, free/total PSA, and prostate volume were independent predictors for prostate cancer. Multivariate Cox regression analyses identified an elevated monocyte count as an independent prognostic factor for worse cancer-specific survival （hazard ratio = 2.244, P 〈 0.05） and overall survival （hazard ratio = 1.995, P 〈 0.05）, but not progression-free survival （P = 0.117）. Our results indicated that an elevated monocyte count was an independent diagnostic biomarker for prostate cancer, and pretreatment peripheral monocyte count might play a significant role in the prognosis of prostate cancer patients treated with androgen deprivation therapy.

关键词： diagnosis monocyte prognosis prostate cancer

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Characteristics of the TCR Vβ repertoire in imatinib-resistant chronic myeloid leukemia patients with ABL mutations

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Science China(Life Sciences) 2015年第12期58卷 1276-1281页

作者： XU Ling LU Yu Hong LAI Jing YU Wei ZHANG Yi Kai JIN Zhen Yi XU yan CHEN Jie ZHA Xian Feng CHEN shao Hua yanG Li jian LI yang qiu Institute of Hematology Jinan University Department of Hematology First Affiliated Hospital Jinan University Department of Hematology Guangzhou No.12 People's Hospital Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University Department of clinical laboratory First Affiliated Hospital Jinan University

Diversity in the T cell receptor(TCR) repertoire provides a miniature defense ability for the T cell immune system that may be related to tumor initiation and progression. Understanding the T cell immune status of leukemia patients is critical for establishing specific immunotherapies. Previous studies have reported abnormal TCR repertoires and clonally expanded TCR V? T cells in chronic myeloid leukemia in chronic phase(CP-CML). In this study, we investigated the distribution and clonality of the TCR V? repertoire in 4 cases with imatinib-resistant CML in blast crisis(BC-CML) with abelson murine leukemia viral oncogene homolog 1(ABL1) kinase domain mutations(KDMs). Examination of TCR V? expression and clonality was performed by reverse transcription-polymerase chain reaction(RT-PCR) and Gene Scan analysis. Significantly skewed TCR V? repertoires were observed in BC-CML patients with different KDMs, and 4 to 8 oligoclonally expanded TCR V? subfamilies could be identified in each sample. Intriguingly, a relatively highly expanded V?9 clone with the same length as complementarity-determining region 3(CDR3)(139 bp) was found in all three CML patients in lymphoid blast crisis(LBC-CML) who had different KDMs, but the clone was not detected in the only CML patient in myeloid blast crisis(MBC-CML). In conclusion, restricted TCR V? repertoire expression and decreased clone complexity was a general phenomenon observed in the BC-CML patients with different KDMs, indicating the T-cell immunodeficiency of these patients. In addition, clonally expanded V?9 T cell clones may indicate a specific immune response to leukemia-associated antigens in LBC-CML patients.

关键词： T cell repertoire chronic myeloid leukemia blast crisis imatinib resistance BCR-ABL mutation

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The Prokaryotic Expression and Bioactivity of the Recombinant Red Fire Ant Venom Allergen Sol i 4

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Agricultural Sciences in China 2009年第2期8卷 182-187页

作者： HAN Xue-qing LIN Xiang-mei CHEN Hong-jun ZHANG Yong-guo YE Gui-sheng WU shao-qiang LI jian CHEN Nai-zhong CHEN yan zhu Shui-fang Chinese Academy of Inspection and Quarantine Beijing 100029 P.R.China

The sting of red imported fire ant （RIFA） could cause serious allergic response in fraction of people. These allergic reactions are mainly caused by its venom, especially venom allergen Sol i 1-4. To produce large amount of RIFA venom allergen Sol i 4 for diagnosis of RIFA allergy and allergen-specific immunotherapy, the gene encoding this protein was amplified and cloned into the prokaryotic expression vector pET43, la. The recombinant plasmid was used to transform competent cells and the recombinant proteins were expressed in E. coll. SDS-PAGE and Western blotting analysis indicated that high-level expression of Sol i 4 protein was successfully achieved. Allergenic activity analysis of the recombinant allergen Sol i 4 was then performed on rabbit. The result showed that the recombinant protein obtained had significant allergenic activity. It indicated that the recombinant allergen Sol i 4 of RIFA venom was successfully expressed in E. coli, which provided foundation for further developing therapeutic and diagnosis reagents of RIFA allergy.

关键词： red imported fire ant recombinant allergen Sol i 4 expression activity

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