Strategies and challenges in the treatment of chronic venous leg ulcers
作者机构：Department of General Surgery and Vascular SurgeryAviation General HospitalChina Medical UniversityBeijing 100012China Department of DermatologyAviation General HospitalBeijing 100012China Department of General SurgeryTaian Communications HospitalTaian 271000Shandong ProvinceChina Department of SurgeryTianjin Hexi HospitalTianjin 300202TianjinChina Department of Orthopaedic SurgeryAviation General HospitalChina Medical UniversityBeijing 100012China Department of SurgeryWanquanqu Zhongyi HospitalZhangjiakou 076250Hebei ProvinceChina Department of Medical AdministrativeAviation General HospitalChina Medical UniversityBeijing 100012China Department of General SurgeryAviation General HospitalChina Medical UniversityBeijing 100012China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2020年第8卷第21期
页 面：5070-5085页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Chronic venous leg ulcers Debridement Compression Negative pressure wound therapy Autologous split-thickness skin grafting Hair punch graft Platelet-rich plasma Advanced wound care therapies
摘 要：Evaluating patients with chronic venous leg ulcers(CVLUs)is essential to find the underlying *** basic tenets in managing CVLUs are to remove the etiological causes,to address systemic and metabolic conditions,to examine the ulcers and artery pulses,and to control wound infection with debridement and eliminating excessive pressure on the *** first-line treatments of CVLUs remain wound care,debridement,bed rest with leg elevation,and *** to support the efficacy of silver-based dressings in healing CVLUs is *** peroxide is harmful to the growth of granulation tissue in the *** options include a high ligation with or without stripping or ablation of the GSVs depending on venous reflux or ***,not all CVLUs are candidates for surgical treatment because of *** standard care of wound for 4 wk failed to heal CVLUs effectively,use of advanced wound care should be considered based on the available *** pressure wound therapy facilitates granulation tissue development,thereby helping closure of *** split-thickness skin grafting is still the gold standard approach to close huge *** punch graft appears to have a better result than traditional hairless punch graft for *** of adipose tissue or placenta-derived mesenchymal stem cells is a promising therapy for wound *** platelet-rich plasma provides an alternative strategy for surgery for safe and natural healing of the *** confirmative efficacy of current advanced ulcer therapies needs more robust evidence.
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