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Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 111-119页

作者： Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati seyedeh-sara hashem. Zahra GhasempourFarsani Hoda Mogholi Gerashi Marzieh Rashedinia Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazFarsIran Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Research Center Yasuj University of Medical SciencesYasujIran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazIran

Objective:To determine the effects of syringic acid on hepatic damage in diabetic ***:Diabetes was induced by *** rats were given syringic acid at doses of 25,50 and 100 mg/kg by oral gavage for 6 *** acid effects on the liver were evaluated by examination of plasma biochemical parameters,and pathological *** addition,biomarkers of lipid peroxidation and antioxidant status of liver tissues were *** time-PCR was performed to investigate the m RNA expression levels of mitochondrial biogenesis indices in different ***:Syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic ***,syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic *** was no difference between the glutathione content of the treated and untreated *** findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic *** acid also significantly upregulated the hepatic m RNA expression of PGC-1α,NRF-1,and NRF-2 and increased the mtD NA/nD NA ratio in diabetic ***:Syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic ***,it has the potential of targeting hepatic mitochondria in diabetes.

关键词： Syringic acid Diabetic Liver Oxidative stress Mitochondrial biogenesis Rats

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Zinc Sulphate and Nano-Zinc Oxide Effects on Some Physiological Parameters of Rosmarinus officinalis

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American Journal of Plant Sciences 2017年第11期8卷 2635-2649页

作者： Sasan Mohsenzadeh seyedeh sara Moosavian Department of Biology Faculty of Sciences Shiraz University Shiraz Iran

In the present study, the effects of foliar application of zinc sulphate and nano-zinc oxide on physiological indices (chlorophyll and carotenoids content, antioxidant activity, total phenolic content, proline, lipid peroxidation and sugar) of rosemary were evaluated. Greenhouse cultivation experiment in a randomized complete block with three levels of foliar zinc and three levels of foliar nano-zinc oxide and control treatment, each with three replications, was carried out. The results showed that low concentrations of zinc and nano-zinc oxide significantly increased chlorophyll and carotenoid compared to the control. Whereas with the high concentration of nano-zinc oxide, chlorophyll and carotenoid decreased compared to the control. Antioxidant enzymes activity increased with zinc and nano-zinc oxide compared to control plants. In addition, proline, membrane lipid peroxidation, soluble sugar and phenolic compounds increased in the treated plants. Proline and plant antioxidant enzymes to scavenge free radicals have increased. Two levels of zinc increased the total phenolic compounds of rosemary leaves significantly but nano-zinc oxide did not show a significant difference compared to the control.

关键词： Nanoparticle Physiological Response Rosemary Zinc

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MRI tracking of human Wharton’s jelly stem cells seeded onto acellular dermal matrix labeled with superparamagnetic iron oxide nanoparticles in burn wounds

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Burns & Trauma 2022年第1期10卷 129-141页

作者： Davood Mehrabani Mehra Nazempour Rouhollah Mehdinavaz-Aghdam seyedeh-sara hashem. Reza Jalli Mahdi Saeedi Moghadam Shahrokh Zare Iman Jamhiri Javad Moayedi Feridoun Karimi-Busheri Stem Cell Technology Research Center Shiraz University of Medical SciencesShirazFars T6G 2E171348-14336Iran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazFars 71987-74731Iran Comparative and Experimental Medicine Center Shiraz University of Medical SciencesShirazFars 71348-14336Iran Li Ka Shing Center for Health Research and Innovation University of AlbertaEdmontonAlbertaCanada Department of Biomedical and Tissue Engineering Science and Research BranchIslamic Azad UniversityTehranIran School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran ***Iran Medical Imaging Research Center Department of RadiologyShiraz University of Medical SciencesShirazFars 71348-14336Iran Department of Biochemistry School of Biotechnology and AgricultureShiraz BranchIslamic Azad UniversityShirazFars 71987-74731Iran Department of Oncology Faculty of MedicineUniversity of AlbertaEdmontonAlbertaT6G 1Z2Canada

Background:In vivo cell tracking after transplantation in regenerative medicine remains an unmet challenge and limits current understanding of the wound healing mechanism through cell-based *** study investigated tracking of human Wharton’s jelly stem cells(hWJSCs)seeded onto an acellular dermal matrix(ADM)and labeled with superparamagnetic iron oxide nanoparti-cles(SPIONs)by magnetic resonance imaging(MRI)in burn ***:The hWJSCs were characterized and assessed for growth kinetics.A total of 30 rats were enrolled in three equal *** 1 underwent scald burn injury left without treatment,the group 2 was treated by an ADM that was prepared from cosmetic surgery skin samples and the group 3 received hWJSCs labeled with SPIONs seeded onto an *** strength was evaluated before and after interventions,real time PCR assessed apoptosis,and Prussian blue staining,scanning electron microscopy(SEM)and MRI were used for the tracking of labeled ***:The hWJSCs exhibited mesenchymal stem cell *** doubling time was 40.1 *** did not show any toxic *** hWJSCs seeded onto an ADM decreased Bax and increased Bcl-2 gene *** of SPIONs within hWJSCs was confirmed by Prussian blue staining,SEM and MRI until day *** was a significant difference between the Young’s moduli of normal skin and the group receiving hWJSCs seeded onto an *** observations and SEM imaging confirmed that MRI is an accurate method to track SPION-labeled hWJSCs in ***:This study showed that SPION labeling coupled with MRI can be used to further understand the fate of stem cells after transplantation in a burn model.

关键词： Wharton’s jelly stem cells Superparamagnetic iron oxide nanoparticles Acellular dermal matrix Magnetic resonance imaging Healing Burn

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On the Generality of Orthogonal Projections and e-Projections in Banach Algebras

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Advances in Pure Mathematics 2012年第5期2卷 318-322页

作者： Mohammad Sadegh Asgari seyedeh sara Karimizad Hamidreza Rahimi Department of Mathematics Faculty of Science Islamic Azad University Central Tehran Branch Tehran Iran

In this paper we develop the orthogonal projections and e-projections in Banach algebras. We prove some necessary and sufficient conditions for them and their spectrums. We also show that the sum of two generalized orthogonal projections u and v is a generalized orthogonal projection if, uv=vu=0. Our results generalize the results obtained for bounded linear operators on Hilbert spaces.

关键词： Generalized Orthogonal Projection Orthogonal Projection Generalized e-Projection e-Projection

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A Comparative Study on the Effects of Vaginal Misoprostol and Vaginal Misoprostol Plus Estradiol on Labor Induction

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Journal of Clinical and Nursing Research 2022年第2期6卷 68-75页

作者： seyedeh Azam Pourhoseini sara Mirzaeian Masuomeh Mirteimouri Mona Najaf Najafi Fatemeh Tara Farideh Akahlghi Elham Abdollahi Department of Obstetrics and Gynecology School of MedicineMashhad University of Medical SciencesMashhadIran Department of Community Medicine School of MedicineMashhad University of Medical SciencesMashhadIran

Background:Cervical ripening is an important factor in predicting successful labor *** an unfavorable cervix,ripening should be done before *** this study,the effect of misoprostol and that of misoprostol plus estradiol on cervical ripening were ***:This randomized,double-blinded study included a total of 190 pregnant women who were identified for pregnancy termination due to maternal or fetal cause at 37 weeks with Bishop score of less than *** patients were assessed between April 2015 to April 2016 in two university hospitals at northeast Iran(Omol-Banin Hospital and Emam Reza Hospital,Mashhad).The patients who met the inclusion criteria were randomly assigned to two groups:the intervention group(Group A),who received 25 micrograms of vaginal misoprostol plus 50 micrograms of estradiol,and the control group(Group B),who received 25 micrograms of vaginal misoprostol *** was administered at 4-hour intervals until cervical ripening(Bishop score≥8)or upon initiation of active phase in both the *** maximum dosage of misoprostol was three doses,whereas estradiol was administered only ***:In this study,the main causes of pregnancy termination were ROM and *** was no significant statistical difference in the Bishop score between the two groups(P=0.13).In addition,no significant difference was observed in the duration of time for cervical ripening(Bishop≥8)between the two groups(P=0.7).The duration between drug administration to the initiation of active phase and also from active phase to delivery showed no significant differences between the two groups(P=0.49 and 0.24,respectively).There was also no significant difference in the delivery route(operative vaginal delivery or Cesarean section)(P=0.2 and P=0.91,respectively).Conclusion:From this study,the use of misoprostol plus estradiol did not improve cervical ripening or decrease the induction *** studies are recommended to investigate comp

关键词： Misoprostol Estradiol valerate Labor induction

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