Syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats

作     者：Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra GhasempourFarsani Hoda Mogholi Gerashi Marzieh Rashedinia Zahra Sabahi;Mohammad Javad Khoshnoud;Bahman Khalvati;Seyedeh-Sara Hashemi;Zahra Ghasempour Farsani;Hoda Mogholi Gerashi;Marzieh Rashedinia

作者机构：Medicinal Plants Processing Research CenterShiraz University of Medical SciencesShirazFarsIran Department of Pharmacology and ToxicologySchool of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Research CenterYasuj University of Medical SciencesYasujIran Burn and Wound Healing Research CenterShiraz University of Medical SciencesShirazIran 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2020年第10卷第3期

页      面：111-119页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by Shiraz University of Medical Sciences(Grant number:95-01-70-12474) 

主　　题：Syringic acid Diabetic Liver Oxidative stress Mitochondrial biogenesis Rats 

摘      要：Objective:To determine the effects of syringic acid on hepatic damage in diabetic ***:Diabetes was induced by *** rats were given syringic acid at doses of 25,50 and 100 mg/kg by oral gavage for 6 *** acid effects on the liver were evaluated by examination of plasma biochemical parameters,and pathological *** addition,biomarkers of lipid peroxidation and antioxidant status of liver tissues were *** time-PCR was performed to investigate the m RNA expression levels of mitochondrial biogenesis indices in different ***:Syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic ***,syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic *** was no difference between the glutathione content of the treated and untreated *** findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic *** acid also significantly upregulated the hepatic m RNA expression of PGC-1α,NRF-1,and NRF-2 and increased the mtD NA/nD NA ratio in diabetic ***:Syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic ***,it has the potential of targeting hepatic mitochondria in diabetes.