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syringic acid improves oxidative stress and mitochondrial biogenesis in the liver of streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 111-119页

作者： Zahra Sabahi Mohammad Javad Khoshnoud Bahman Khalvati Seyedeh-Sara Hashemi Zahra GhasempourFarsani Hoda Mogholi Gerashi Marzieh Rashedinia Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazFarsIran Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Research Center Yasuj University of Medical SciencesYasujIran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazIran

Objective:To determine the effects of syringic acid on hepatic damage in diabetic ***:Diabetes was induced by *** rats were given syringic acid at doses of 25,50 and 100 mg/kg by oral gavage for 6 *** acid effects on the liver were evaluated by examination of plasma biochemical parameters,and pathological *** addition,biomarkers of lipid peroxidation and antioxidant status of liver tissues were *** time-PCR was performed to investigate the m RNA expression levels of mitochondrial biogenesis indices in different ***:syringic acid significantly attenuated the increase in most of plasma biochemical parameters in diabetic ***,syringic acid treatment increased the catalase activity while it reduced the superoxide dismutase activity and hepatic malondialdehyde level in diabetic *** was no difference between the glutathione content of the treated and untreated *** findings were supported by alleviation of histopathological damages in the syringic acid-treated groups compared to the untreated diabetic *** acid also significantly upregulated the hepatic m RNA expression of PGC-1α,NRF-1,and NRF-2 and increased the mtD NA/nD NA ratio in diabetic ***:syringic acid can be considered as a suitable candidate against hepatic complications since it can reduce oxidative damages in diabetic ***,it has the potential of targeting hepatic mitochondria in diabetes.

关键词： syringic acid Diabetic Liver Oxidative stress Mitochondrial biogenesis Rats

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