A Comparative Study on the Effects of Vaginal Misoprostol and Vaginal Misoprostol Plus Estradiol on Labor Induction

作     者：Seyedeh Azam Pourhoseini Sara Mirzaeian Masuomeh Mirteimouri Mona Najaf Najafi Fatemeh Tara Farideh Akahlghi Elham Abdollahi 

作者机构：Department of Obstetrics and GynecologySchool of MedicineMashhad University of Medical SciencesMashhadIran Department of Community MedicineSchool of MedicineMashhad University of Medical SciencesMashhadIran 

出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)

年 卷 期：2022年第6卷第2期

页      面：68-75页

学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：Misoprostol Estradiol valerate Labor induction 

摘      要：Background:Cervical ripening is an important factor in predicting successful labor *** an unfavorable cervix,ripening should be done before *** this study,the effect of misoprostol and that of misoprostol plus estradiol on cervical ripening were ***:This randomized,double-blinded study included a total of 190 pregnant women who were identified for pregnancy termination due to maternal or fetal cause at 37 weeks with Bishop score of less than *** patients were assessed between April 2015 to April 2016 in two university hospitals at northeast Iran(Omol-Banin Hospital and Emam Reza Hospital,Mashhad).The patients who met the inclusion criteria were randomly assigned to two groups:the intervention group(Group A),who received 25 micrograms of vaginal misoprostol plus 50 micrograms of estradiol,and the control group(Group B),who received 25 micrograms of vaginal misoprostol *** was administered at 4-hour intervals until cervical ripening(Bishop score≥8)or upon initiation of active phase in both the *** maximum dosage of misoprostol was three doses,whereas estradiol was administered only ***:In this study,the main causes of pregnancy termination were ROM and *** was no significant statistical difference in the Bishop score between the two groups(P=0.13).In addition,no significant difference was observed in the duration of time for cervical ripening(Bishop≥8)between the two groups(P=0.7).The duration between drug administration to the initiation of active phase and also from active phase to delivery showed no significant differences between the two groups(P=0.49 and 0.24,respectively).There was also no significant difference in the delivery route(operative vaginal delivery or Cesarean section)(P=0.2 and P=0.91,respectively).Conclusion:From this study,the use of misoprostol plus estradiol did not improve cervical ripening or decrease the induction *** studies are recommended to investigate comp