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Downed logs improve soil properties in old-growth temperate forests of northern Iran

Pedosphere 2020年第3期30卷 378-389页

作者： Negar MOGHIMIAN seyed gholamali jalali Yahya KOOCH Ana REY Faculty of Natural Resources&Marine Sciences Tarbiat Modares UniversityNoor 46417-76489Iran Department of Biogeography and Global Change National Museum of Natural History(MNCN)Spanish Scientific Council(CSIC)C/Serrano 115bisMadrid 28006(Spain

Dead trees, particularly downed logs, play an important role in the dynamics of forest ecosystem. Contribution of decaying wood to C and nutrient pools of forest soils depends on the tree species and degree of wood decay. However, the extent to which the downed logs affect the soil properties of temperate forests has rarely been evaluated. In this study, a mixed beech forest was selected in Liresar region of Mazandaran Province, northern Iran, to investigate if and how the presence of downed logs affected soil quality and function by comparing soils underneath degraded logs and nearby soils of the two dominant tree species(beech and hornbeam). We then explored how these effects occurred as downed logs decomposed by comparing the woods of both tree species at four degrees of decomposition. Degree of decay of downed logs was classified into four classes(DC1–DC4). Eight dead trees of each tree species were selected at the center of each sample plot. Three composite soil samples underneath each decaying log and 100 cm away from a decaying log were collected at two soil depths(0–15 and 15–30 cm) to analyze soil main physicochemical properties and microbial activity. The results revealed that downed logs affected soil physical(5% wetter than control soils), chemical(2% lower pH, 100% increase in organic C and total N in the case of hornbeam, and 2% increase in P), and biological characteristics(soil microbial respiration enhanced by 10%, and microbial biomass C 620 and 351.5 mg kg-1 and microbial biomass N 66.47 and 32.18 mg kg-1, respectively, in the cases of beech and hornbeam), thus resulting in significantly different soil microsites from those without downed logs. Presence of downed logs increased soil microbial activity and soil fertility as wood decayed. Thus, the presence of downed logs is an important factor influencing forest soils and should be taken into consideration in forest management practices.

关键词： beech course woody debris dead tree decay degree hornbeam soil microbial activity soil physicochemical properties

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Leaf macro-and micro-morphological altitudinal variability of Carpinus betulus in the Hyrcanian forest (Iran)

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Journal of Forestry Research 2013年第2期24卷 301-307页

作者： Iman Chapolagh Paridari seyed gholamali jalali Ali Sonboli Mehrdad Zarafshar Piero Bruschi Department of Forestry Natural Resources Faculty Tarbiat Modares University Department of Biology Medicinal Plants and Drugs Research Institute Shahid Beheshti University Department of Agriculture Biotechnology - Section of Environmental and Applied Botany University of Florence

We investigated the altitudinal variation of Carpinus betulus L. in the Hyrcanian forest using leaf macro-morphological and micro-morphological traits. We collected a total of 1600 leaves from two locations. In each location, we sampled six populations along an altitudinal gradient ranging from 100 m to 1,150 m. We found that trees in the higher elevations have smaller leaf lamina than those in the lower elevations. In contrast, leaf mass per area was high at low altitudes and increased newly at the higher ones. Stomatal dimension was negatively correlated with elevation, while stomatal density was positively correlated with elevation. We also found that two transects showed the same plasticity trend. Leaf area showed the highest plasticity, while the number of veins showed the lowest plasticity. This study shows that altitude, and related temperature and rainfall, represents an important driving force in Carpinus betulus leaf morphological variation. Moreover, our results suggest that leaf area, leaf mass per area and stomatal density could influence the species responses to different ecological conditions.

关键词： adaptation elevational transect leaf mountain forest stomata

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Sound & Vibration 2019年第6期53卷 263-276页

作者： Jahede Tekeykhah seyed Mohsen Hosseini gholamali jalali Jalil Alavi Abbas Esmaili Sari Forestry Department Natural Resources and Marine Sciences FacultyTarbiat Modares UniversityNoorMazandaranIran Faculty of Natural Resources Tarbiat Modares UniversityNoorMazandaranIran Associate Professor of Forestry Department Tarbiat Modares UniversityNoorMazandaranIran Forestry Department Tarbiat Modares UniversityNoorMazandaranIran Department of Environmental Science Tarbiat Modares UniversityNoorMazandaranIran

Sound pollution is one of the most important urban problems which endangers mental and physical health of the *** study was aimed to assess the influence of different tree species,including Fraxinus rotundifolia,Robinia pseudoacacia,Platanus orientalis,Platycladus orientalis,and Pinus eldarica,in reducing noise pollution in the Abidar Forest Park.A further objective was to identify the contaminated areas of Sanandaj city and to propose suitable noise absorbent tree species in consistent *** each tree stands the noise measurements were performed during intervals at frequencies of 250,500 and 1000 Hz,besides an open area with the same *** regards to the second purpose,a total of 50 stations with residential,commercial,residentialcommercial,and green space applications were selected across the *** Continuous Sound Pressure Level(Leq)was determined in five replicates for 30 *** measurements were performed under stable weather conditions and low wind velocity at 17:00(traffic peak)in summer and *** of the Leq values were above the threshold noise *** highest noise reduction was recorded in summer(i.e.,green season);Platanus and Platycladus species demonstrated the highest and lowest noise absorption(31.43 dB and 22.28 dB,respectively).Furthermore,a meaningful difference was observed between Leq values of commercial,residential,commercial-residential,and green space urban applications,and the central parts of the city showed noticeable noise *** together,due to being exposed to higher than the acceptable threshold noise level,the residents of Sanandaj will be endangered to health problems in the near future;thus consideration should be given to the noise pollution sources.

关键词： Urban green space noise attenuation Abidar Forest Park

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An Efficient Hybrid Model Based on Modified Whale Optimization Algorithm and Multilayer Perceptron Neural Network for Medical Classification Problems

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Journal of Bionic Engineering 2022年第5期19卷 1504-1521页

作者： Saeid Raziani Sajad Ahmadian seyed Mohammad Jafar jalali Abdolah Chalechale Department of Computer Engineering Razi UniversityKermanshah ***Iran Faculty of Information Technology Kermanshah University of TechnologyKermanshah ***Iran Institute for Intelligent Systems Research and Innovation(IISRI) Deakin UniversityWaurn PondsMelbourne 3217Australia

Feedforward Neural Network(FNN)is one of the most popular neural network models that is utilized to solve a wide range of nonlinear and complex *** models such as stochastic gradient descent have been developed to train ***,they mainly suffer from falling into local optima leading to reduce the accuracy of ***,the convergence speed of training process depends on the initial values of weights and biases in ***,these values are randomly determined by most of the training *** deal with these issues,in this paper,we develop a novel evolutionary algorithm by modifying the original version of Whale Optimization Algorithm(WOA).To this end,a nonlinear function is introduced to improve the exploration and exploitation phases in the search process of ***,the modified WOA is applied to automatically obtain the initial values of weights and biases in FNN leading to reduce the probability of falling into local *** addition,the FNN model trained by the modified WOA is used to develop a classification approach for medical diagnosis *** medical diagnosis datasets are utilized to evaluate the efficiency of the proposed ***,four evaluation metrics including accuracy,AUC,specificity,and sensitivity are used in the experiments to compare the performance of classification *** experimental results demonstrate that the proposed method is better than other competing classification models due to achieving higher values of accuracy,AUC,specificity,and sensitivity metrics for the used datasets.

关键词： Feed forward neural network Meta-heuristic algorithm Whale optimization algorithm Optimization Classification Bionic algorithm

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The Nuclear Factor KappaB(NF-kB)signaling in cancer development and immune diseases

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Genes & Diseases 2021年第3期8卷 287-297页

作者： Mohammad Reza Zinatizadeh Bettina Schock Ghanbar Mahmoodi Chalbatani Peyman Kheirandish Zarandi seyed Amir jalali seyed Rouhollah Miri Cancer Research Center Shahid Beheshti University of Medical SciencesTehran***Iran Centre for Experimental Medicine Queen’s University BelfastBelfastBT71NNUnited Kingdom Department of Medical Immunology School of MedicineTehran University of Medical SciencesTehran***Iran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehran***Iran Department of Medical Immunology School of MedicineShahid Beheshti University of Medical SciencesTehran***Iran

The nuclear factor kappa B(NF-kB)family of transcription factors plays an essential role as stressors in the cellular environment,and controls the expression of important regula-tory genes such as immunity,inflammation,death,and cell ***-kB protein is located in the cytoplasm,and can be activated by various cellular *** are two path-ways for NF-kB activation,as the canonical and non-canonical pathways,which require com-plex molecular interactions with adapter proteins and phosphorylation and ubiquitinase ***,this increases NF-kB translocation in the nucleus and regulates gene *** this study,the concepts that emerge in different cellular systems allow the design of NF-kB function in *** would not only allow the development for rare dis-eases associated with NF-kB,but would also be used as a source of useful information to elim-inate widespread consequences such as cancer or inflammatory/immune diseases.

关键词： Cancer Immunity Inflammation NF-kB Signaling

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Prediction of cavity growth rate during underground coal gasification using multiple regression analysis

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International Journal of Coal Science & Technology 2015年第4期2卷 318-324页

作者： Mehdi Najafi seyed Mohammad Esmaiel jalali Reza KhaloKakaie Farrokh Forouhandeh Department of Mining and Metallurgical Engineering YazdUniversity Safayieh P.O. Box 89195-741 Yazd Iran Faculty of Mining Engineering Petroleum and GeophysicsShahrood University Shahrud Iran Department of Mathematics Shahrood University ShahrudIran

During underground coal gasification （UCG）, whereby coal is converted to syngas in situ, a cavity is formed in the coal seam. The cavity growth rate （CGR） or the moving rate of the gasification face is affected by controllable （operation pressure, gasification time, geometry of UCG panel） and uncontrollable （coal seam properties） factors. The CGR is usually predicted by mathematical models and laboratory experiments, which are time consuming, cumbersome and expensive. In this paper, a new simple model for CGR is developed using non-linear regression analysis, based on data from 1 l UCG field trials. The empirical model compares satisfactorily with Perkins model and can reliably predict CGR.

关键词： Underground coal gasification (UCG) - Cavity growth rate . Multiple regression analysis ~ Empirical model

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CAR-T cells: Early successes in blood cancer and challenges in solid tumors

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1129-1147页

作者： Hassan Dana Ghanbar Mahmoodi Chalbatani seyed Amir jalali Hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina Raposo Thomas J.Webster Cancer Research Center Cancer Institute of IranTehran University of Medical SciencesTehran 13145-158Iran Department of Medical Immunology School of MedicineTehran University of Medical SciencesTehran ***Iron Department of Immunology School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Division of Oncology Department of Pediatricsthe Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Center for Natural and Human Sciences Federal University of ABCSanto AndreSP 09210-580Brazil Faculty of Pharmaceutical Sciences State University of Campinas(UNICAMP)CampinasSP 13083-87JBrazil Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA

New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully.

关键词： Immunotherapy T cell therapy Chimeric antigen receptor(CAR) Genetic engineering

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Factor XIII VaU34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population： a case control study

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Frontiers in Biology 2016年第6期11卷 471-475页

作者： seyed Mehdi Sajjadi Abbas Khosravi Jalil Pakravesh Zahra-soheila Soheili Shahram Samiei Saeed Mohammadi Mohammad Ali jalali far Cellular and Molecular Research Center of Birjand University of Medical Sciences Biriand Iran Department of Hematology Tehran University of Allied Medical Sciences Tehran Iran Department of Obstetrics and Gynecology Aban General Hospital Tehran Iran Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology Tehran Iran Blood Transfusion Research center High Institute for Research and Education in Transfusion Medicine Tehran Iran Hematology Oncology and Stem Cell Translantation Research Center Tehran University of Medical Sciences Tehran Iran Health research institute Research Center of Thalassemia & Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences AhvazIran

BACKGROUND： Recurrent pregnancy loss （RPL） is a heterogeneous condition and thrombophilias have been considered as a probable cause. OBJECTIVE： The aim of this study was to investigate the prevalence of the coagulation factor XIII Va134Leu polymorphism among women with unexplained RPL. METHODS： A total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Va134Leu polymorphism among the cases and controls was investigated using PCR-RFLP method. RESULTS： Genotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls （P〈 0.05）： 33.5% vs. 15%, and 9.2% vs. 2%, respectively. CONCLUSION： These results indicate a significant association between FXIII Va134Leu polymorphism and unexplained RPL in the Iranian patient.

关键词： factor XIII Iranian population recurrent pregnancy loss Va134Leu polymorphism

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MicroRNAs in erythropoiesis and red blood cell disorders

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Frontiers in Biology 2015年第4期10卷 321-332页

作者： Javad Mohammdai-asl Abolfazl Ramezani Fatemeh Norozi Amal Saki Malehi Ali Amin Asnafi Mohammad Ali jalali Far seyed Hadi Mousavi Najmaldin Saki Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Healthresearch Institute Research Center of Thalassemia & Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Biostatistics and Epidemiology School of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Hematology Department Allied Medical School Tehran University of Medical Sciences Tehran Iran

MicroRNAs （miRNAs） are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways in niche of hematopoietic cells, transcription factors as well as miRNAs. Expression of different types of miRNAs during erythroid development provides a background for the study of these molecules to control erythroid differentiation and maturation as well as their use as diagnostic and prognostic markers to treat erythroid disorders like thalassemia, sickle cell disease and erythrocyte enzyme deficiencies. In this paper, with reference to biosynthesis of miRNAs, their function in normal and anemic erythropoiesis has been investigated. The target molecule of each of these miRNAs has been cited in an attempt to elucidate their role in erythropoiesis.

关键词： miRNA erythropoiesis red blood cell

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Evaluation of imatinib mesylate(Gleevec) on KAI1/CD82 gene expression in breast cancer MCF-7 cells using quantitative real-time PCR

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 159-163页

作者： seyed Ataollah Sadat Shandiz Marjan Khosravani Sepideh Mohammadi Hassan Noorbazargan Amir Mirzaie Davoud Nouri Inanlou Mojgan Dalirsaber jalali Hamidreza Jouzaghkar Fahimeh Baghbani-Arani Behta Keshavarz-Pakseresht Young Researchers and Elite Club East Tehran Branch Islamic Azad University Department of Microbiology Shiraz Azad University Department of Microbiology Islamic Azad University Pharmaceutical Sciences Branch Department of Biotechnology Shahid Beheshti University of Medical Sciences R&D Department Research and Production Complex Pasteur Institute of Iran Department of Microbiology Faculty of Basic Science Young Researcher Club Lahijan Branch Islamic Azad University Department of Genetics & Biotechnology School of Biological Science Varamin-Pishva Branch Islamic Azad University

Objective: To evaluate the effect of imatinib mesylate on cell viability, anti cancer effect through modulation of KAI1/CD82 gene expression in breast cancer MCF-7 cell ***: The effects of imatinib mesylate on cell viability in MCF-7 cell line were assessed using MTT assay and IC_(50) value was determined. GAPDH and KAI1/CD82 were selected as reference and target genes, respectively. Quantitative real time PCR technique was applied for investigation of KAI1/CD82 gene expression in human breast cancer MCF-7 cells. Subsequently, the quantity of KAI1 compared to GAPDH gene expressions were analyzed using the formula; 2^(-DDCt).Results: Imatinib was showed to have a dose-dependent inhibitory effect on the viability of MCF-7 cells. CD82/GAPDH gene expression ratios were 1.322 ± 0.030(P > 0.05),2.052 ± 0.200(P < 0.05), 2.151 ± 0.270(P < 0.05) for 10, 20 and 40 mmol/L of imatinib ***: Based on the present data, imatinib mesylate might modulate metastasis by up-regulating KAI1/CD82 gene expression in human breast MCF-7 cancer cell line.

关键词： Imatinib mesylate KAI1/CD82 Metastasis Breast cancer Real-time PCR

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