The Nuclear Factor KappaB(NF-kB)signaling in cancer development and immune diseases

作     者：Mohammad Reza Zinatizadeh Bettina Schock Ghanbar Mahmoodi Chalbatani Peyman Kheirandish Zarandi Seyed Amir Jalali Seyed Rouhollah Miri 

作者机构：Cancer Research CenterShahid Beheshti University of Medical SciencesTehran***Iran Centre for Experimental MedicineQueen’s University BelfastBelfastBT71NNUnited Kingdom Department of Medical ImmunologySchool of MedicineTehran University of Medical SciencesTehran***Iran Cancer Research CenterCancer Institute of IranTehran University of Medical ScienceTehran***Iran Department of Medical ImmunologySchool of MedicineShahid Beheshti University of Medical SciencesTehran***Iran 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2021年第8卷第3期

页      面：287-297页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cancer Immunity Inflammation NF-kB Signaling 

摘      要：The nuclear factor kappa B(NF-kB)family of transcription factors plays an essential role as stressors in the cellular environment,and controls the expression of important regula-tory genes such as immunity,inflammation,death,and cell ***-kB protein is located in the cytoplasm,and can be activated by various cellular *** are two path-ways for NF-kB activation,as the canonical and non-canonical pathways,which require com-plex molecular interactions with adapter proteins and phosphorylation and ubiquitinase ***,this increases NF-kB translocation in the nucleus and regulates gene *** this study,the concepts that emerge in different cellular systems allow the design of NF-kB function in *** would not only allow the development for rare dis-eases associated with NF-kB,but would also be used as a source of useful information to elim-inate widespread consequences such as cancer or inflammatory/immune diseases.