MicroRNAs in erythropoiesis and red blood cell disorders
MicroRNAs in erythropoiesis and red blood cell disorders作者机构：Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Healthresearch Institute Research Center of Thalassemia & Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Biostatistics and Epidemiology School of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Hematology Department Allied Medical School Tehran University of Medical Sciences Tehran Iran
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2015年第10卷第4期
页 面：321-332页
核心收录：
学科分类：071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 090102[农学-作物遗传育种] 0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0901[农学-作物学] 0836[工学-生物工程] 0713[理学-生态学]
主 题：miRNA erythropoiesis red blood cell
摘 要：MicroRNAs （miRNAs） are 19-24 nucleotide non-coding ribonucleic acids binding DNA or RNA and controlling gene expression via mRNA degradation or its transcription inhibition. Erythropoies is a multi step differentiation process of erythroid progenitors to nucleate red blood cells. Maturation, proliferation and differentiation of red blood cells is affected by erythroid factors, signaling pathways in niche of hematopoietic cells, transcription factors as well as miRNAs. Expression of different types of miRNAs during erythroid development provides a background for the study of these molecules to control erythroid differentiation and maturation as well as their use as diagnostic and prognostic markers to treat erythroid disorders like thalassemia, sickle cell disease and erythrocyte enzyme deficiencies. In this paper, with reference to biosynthesis of miRNAs, their function in normal and anemic erythropoiesis has been investigated. The target molecule of each of these miRNAs has been cited in an attempt to elucidate their role in erythropoiesis.
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