Factor XIII VaU34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population： a case control study

作     者：Seyed Mehdi Sajjadi Abbas Khosravi Jalil Pakravesh Zahra-soheila Soheili Shahram Samiei Saeed Mohammadi Mohammad Ali Jalali far 

作者机构：Cellular and Molecular Research Center of Birjand University of Medical Sciences Biriand Iran Department of Hematology Tehran University of Allied Medical Sciences Tehran Iran Department of Obstetrics and Gynecology Aban General Hospital Tehran Iran Cellular and Molecular Biology National Institute of Genetic Engineering and Biotechnology Tehran Iran Blood Transfusion Research center High Institute for Research and Education in Transfusion Medicine Tehran Iran Hematology Oncology and Stem Cell Translantation Research Center Tehran University of Medical Sciences Tehran Iran Health research institute Research Center of Thalassemia & Hemoglobinopathy Ahvaz Jundishapur University of Medical Sciences AhvazIran 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2016年第11卷第6期

页      面：471-475页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：Vice-Chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences 

主　　题：factor XIII Iranian population recurrent pregnancy loss Va134Leu polymorphism 

摘      要：BACKGROUND： Recurrent pregnancy loss （RPL） is a heterogeneous condition and thrombophilias have been considered as a probable cause. OBJECTIVE： The aim of this study was to investigate the prevalence of the coagulation factor XIII Va134Leu polymorphism among women with unexplained RPL. METHODS： A total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Va134Leu polymorphism among the cases and controls was investigated using PCR-RFLP method. RESULTS： Genotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls （P〈 0.05）： 33.5% vs. 15%, and 9.2% vs. 2%, respectively. CONCLUSION： These results indicate a significant association between FXIII Va134Leu polymorphism and unexplained RPL in the Iranian patient.