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Neural Regeneration Research 2010年第12期5卷 954-957页

作者： Ji heon hong Sung Ho Jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Diffusion tensor tractography （DTT） in diffusion tensor imaging （DTI） examination allows for the three-dimensional visualization of cerebellar peduncles. The present case-control study analyzed the relationship between functional recovery of intracerebral hematoma patient and cerebellar peduncle injury, as detected by DTI. The enrolled patient could not sit at 3 weeks after onset, but was able to walk independently and perform most daily activities after 4 months. The 3-week DTT images revealed that all six cerebellar peduncles were compressed by the hematoma, posterior portions of all three left cerebellar peduncles were shortened, and the left middle cerebellar peduncle was interrupted in the mid-portion. The 4-week DTT images showed that all compressed cerebellar peduncles were ameliorated, although injured posterior portions of the three left cerebellar peduncles did not recover. The fractional anisotropy value of the right inferior cerebellar peduncle increased from two standard deviations below the normal control value to within two standard deviations of the normal control value. These findings suggested that functional recovery was primarily due to decompression of compressed cerebellar peduncles, and not to recovery of injured cerebellar peduncles. DTI evaluations of cerebellar peduncles could be helpful when cerebellar peduncle injury is suspected.

关键词： diffuse tensor imaging cerebellar peduncle injury intracerebral hematoma brain injury cerebellar peduncle

Is combined functional magnetic resonance imaging and diffusion tensor tractography a useful tool for evaluation of somatosensory dysfunction recovery after intracerebral hemorrhage?

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Neural Regeneration Research 2010年第14期5卷 1109-1112页

作者： Ji heon hong Sung Ho Jang Department of Physical Medicine & Rehabilitation Yeungnam University College of Medicine

Diffusion tensor tractography allows the sensory fiber course of the medial lemniscus to be visualized. But diffusion tensor tractography for accurate evaluation of the repair of injured somatosensory tracts in stroke patients has been rarely reported. A 55-year-old female patient presented with severe somatosensory dysfunction of the left side caused by a spontaneous intracerebral hemorrhage on the right side. The somatosensory function of the affected side recovered to a nearly normal state at 7 weeks from onset. Functional magnetic resonance imaging revealed that at 3 weeks from onset, there was no cortical activation by touch at each hand; at 7 weeks, the contralateral cortex centered on the primary sensory cortex was found to be activated during touch and passive movements, and activation by passive movements was increased compared with that at 3 weeks. Diffusion tensor tractography revealed that a medial lemniscus on the affected （right） hemisphere was not observed at 3 weeks from onset, however, at 7 weeks, the unaffected （left） hemisphere passed along the medial lemniscus pathway from the pons to the primary sensory cortex. These findings indicate that combined functional magnetic resonance imaging and diffusion tensor tractography would allow more accurate evaluation of the architecture and integrity of somatosensory tracts and is a useful method to investigate the recovery of somatosensory dysfunction in stroke patients.

关键词： functional magnetic resonance imaging diffusion tensor tractography stroke somatosensory recovery intracerebral hemorrhage brain injury

A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair

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Bioactive Materials 2024年第4期34卷 80-97页

作者： Haeun Chung Jung-Kyun Choi Changgi hong Youngseop Lee Ki Hyun hong seung Ja Oh Jeongmin Kim Soo-Chang Song Jong-Wan Kim Sang-heon Kim Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and TechnologySeoul02792Republic of Korea Department of Applied Bioengineering Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul08826Republic of Korea Research Institute for Convergence Science Seoul National UniversitySeoul08826Republic of Korea Department of Genetics and Biotechnology College of Life SciencesKyung Hee UniversityYongin-siGyeonggi-do17104Republic of Korea S.Biomedics Co. Ltd.Seoul04797Republic of Korea

Critical limb ischemia(CLI)is a devastating disease characterized by the progressive blockage of blood *** the paracrine effect of growth factors in stem cell therapy made it a promising angiogenic therapy for CLI,poor cell survival in the harsh ischemic microenvironment limited its ***,an imperative need exists for a stem-cell delivery method that enhances cell ***,a collagen microgel(CMG)cell-delivery scaffold(40×20μm)was fabricated via micro-fragmentation from collagen-hyaluronic acid polyionic complex to improve transplantation *** human adipose-derived stem cells(hASCs)with CMG enabled integrin receptors to interact with CMG to form injectable 3-dimensional constructs(CMG-hASCs)with a microporous microarchitecture and enhanced mass ***-hASCs exhibited higher cell survival(p<0.0001)and angiogenic potential in tube formation and aortic ring angiogenesis assays than cell *** of CMG-hASCs intramuscularly into CLI mice increased blood perfusion and limb salvage ratios by 40%and 60%,respectively,compared to cell aggregate-treated *** immunofluorescent analysis revealed that transplanted CMG-hASCs have greater muscle regenerative and angiogenic potential,with enhanced cell survival than cell aggregates(p<0.05).Collectively,we propose CMG as a cell-assembling platform and CMG-hASCs as promising therapeutics to treat CLI.

关键词： Regenerative medicine Stem cell therapy Collagen microgel 3D cell culture Critical limb ischemia

Study on SCR De NO_x mechanism through in situ electrical conductivity measurements on V_2O_5-WO_3/TiO_2 catalysts

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Rare Metals 2006年第Z2期25卷 77-83页

作者： HA heon Phil JUNG Soon Hyo LEE Jun Yub hong Sung Ho Metal Processing Research Center Korea Institute of Science and Technology Cheongryang Seoul 130-650 Republic of Korea Power Engineering Research Institute Korea Power Engineering Company Inc. 360-9 Mabuk-ri Guseong-eup Yongin-si Gyeonggi-do 449-713 Republic of Korea

V2O5-WO3/TiO2 catalysts were prepared by impregnation method and in situ electrical conductivity measurements were carried out to investigate the reaction mechanism for ammonia SCR (selective catalytic reduction) of NOx. The electrical conductivity change with ammonia supply and the increase of electrical conductivity were mainly caused by reduction of the labile surface oxygen. The electrical conductivity change of catalysts shows close relationship with the conversion rate of NOx. Variation of conversion rate in atmosphere without gaseous oxygen also supports that the labile lattice oxygen is indispensable in the initial stage of the de NOx reaction. These results suggest that the liable lattice oxygen acts decisive role in the de NOx mechanism. They also support that De NOx reaction occurs through the Eley-Rideal type mechanism. The amount of labile oxygen can be estimated from the measurement of electrical conductivity change for catalysts with ammonia supply.

关键词： De NOx selective catalytic reduction electrical conductivity lattice oxygen

Rational design of ultrafine FeSe_(2) nanocrystals emb e dde d within hollow mesoporous carbon bowls for potassium-ion batteries with long-term cycling stability and high volumetric capacity

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Journal of Materials Science & Technology 2023年第12期143卷 129-139页

作者： Yu Jin Jang hong Geun Oh seung-Keun Park Department of Advanced Materials Engineering Chung-Ang University4726Seodong-daeroDaedeok-myeonAnseong-siGyeonggi-do 17546Republic of Korea

Hollow structures are commonly used to alleviate the mechanical stress on electrode materials and to provide more active sites in potassium-ion batteries(KIBs).Nevertheless,the excessive internal voids within these structures significantly reduce the packing density of particles,resulting in a relatively low volumetric energy density of the fabricated electrodes,which is undesirable for practical *** designed a hollow mesoporous carbon bowl embedded with ultrafine bis(selanylidene)iron(FeSe 2)nanocrystals(FeSe 2@HMCB)via a controllable impregnation method and subsequent selenization pro-cess for high-performance *** as-obtained FeSe 2@HMCB can inherit the advantages of conventional hollow carbon-based composites,such as alleviation of volume variation in active materials,abundant ion storage sites,and high electrical ***,the bowl structure has a higher pack-ing density than the conventional hollow structure,resulting in a significant increase in the volumet-ric energy density of the fabricated *** of these advantages,the FeSe 2@HMCB exhibits a high,stable reversible capacity of 326 mA h g^(-1) even after 1000 cycles at 0.5 A g^(-1),and excellent rate capacities(182 mA h g^(-1) at 3.0 A g^(-1)).Compared with the hollow structured counterpart,the vol-umetric capacity(mA h cm−3)of FeSe 2@HMCB increased by 60%.Furthermore,a full cell consisting of FeSe 2@HMCB//Prussian blue(PB)exhibits excellent electrochemical performance(99 mA h g^(-1) after 100 cycles at 0.1 A g^(-1)).

关键词： Potassium-ion batteries Iron selenide Bowl-like structure Mesoporous carbon Anode material

Posterior reversible encephalopathy syndrome following uneventful clipping of an unruptured intracranial aneurysm:A case report

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World Journal of Clinical Cases 2023年第19期11卷 4723-4728页

作者： Joseph Hwang Won-Ho Cho seung-heon Cha Jun-Kyueng Ko Department of Neurosurgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 49241South Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is characterized mainly by occipital and parietal lobe involvement,which can be reversible within a few ***,we report a rare case of PRES that developed after craniotomy for an unruptured intracranial aneurysm(UIA).CASE SUMMARY A 59-year-old man underwent clipping surgery for the treatment of UIA arising from the left middle cerebral *** surgery was performed uneventfully,and he regained consciousness quickly immediately after the *** the 4th hour after surgery,he developed a disorder of consciousness and *** resonance imaging revealed cortical and subcortical T2/FLAIR hyperintensities in the parietal,occipital,and frontal lobes ipsilaterally,without restricted diffusion,consistent with unilateral *** conservative treatment,his symptoms and radiological findings almost completely disappeared within *** our case,the important causative factor of PRES was suspected to be a sudden increase in cerebral perfusion pressure associated with temporary M1 *** Our unique case highlights that,to our knowledge,this is the second report of PRES developing after craniotomy for the treatment of *** must keep PRES in mind as one of the causes of perioperative neurological abnormality following clipping of an UIA.

关键词： Clipping Magnetic resonance imaging Posterior reversible encephalopathy syndrome Unruptured intracranial aneurysm Case report

Outcomes of men aged≤50 years treated with radical prostatectomy:a retrospective analysis

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Asian Journal of Andrology 2019年第2期21卷 150-155页

作者： Byeongdo Song Hakmin Lee Min seung Lee Sung Kyu hong Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Seoul National University College of MedicineSeoul 03080Korea

Previous studies inv estigating prostate can cer(PCa)features in youn ger men have reported con flicting fin *** study aimed to investigate pathologic outcomes and biochemical recurrenee(BCR)status in younger men who underwent radical prostatectomy(RP)for *** of 2057 patients who underwent RP at Seoul National University Bundang Hospital(Seongnam,Korea)between 2006 and 2015 were reviewed;patients were divided according to age into the younger and older groups(men aged50 years,respectively).Postoperative BCR status and functional outcomes and clinicopathologic features were compared betwee n both *** an alyses were repeated after propensity score matchi *** men were more likely to have lowrisk disease(P<0.001),lower pathologic Gleason score(P<0.001)and pathologic stages(P<0.001)than older *** pathologic Gleason score(P=0.002)and rates of extracapsular extension(P=0.004)were lower in younger men after propensity score *** multivariate analysis,age at RP was not an independent predictor of BCR-free survival after RP(P=0.669).Moreover,at 1 year after RP,younger men with preoperative 5?item International Index of Erectile Function score≥22(n=228)showed more favorable results for urinary con tine nee(defi ned as nonuse of pads daily)(99.4%vs 95%,P=0.009)and erections sufficie nt for vaginal in tercourse(81.8%vs 55.5%,P=0.001).Youn ger men had more favorable clinicopathologic features at RP than their older *** age was not an independent predictor of BCR status outcome,younger men had better functional outcomes following RP.

关键词： age group prostate cancer prostatectomy

N,P co-doped 3D porous carbon with self-assembled morphological control via template-free method for potassiumion battery anodes

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Rare Metals 2024年第9期43卷 4243-4252页

作者： Jeehoon Yu Dae Kyom Kim hong Geun Oh seung-Keun Park Youngjae Yoo Department of Advanced Materials Engineering Chung-Ang UniversityAnseong-si 17546Republic of Korea

The larger ionic radius of potassium ions than that of lithium ions significantly limits the accomplishment of rapid diffusion kinetics in graphite electrodes for potassium-ion batteries(PIBs),resulting in comparatively poor rate performance and cycle ***,we report a high-rate performance and cycling stability amorphous carbon electrode achieved through nitrogen and phosphorous *** as-prepared N,P co-doped carbon electrodes have distinct 3D structures with large surface areas,hierarchical pore architectures,and increased interlayer spaces resulting from the direct pyrolysis of supramolecular self-assembled aggregates without *** obtained electrode N3P1 exhibits a reversible specific capacity of 258 m Ah·g^(-1)at a current density of 0.1A·g^(-1)and a good long-term cycle performance(96.1%capacity retention after 800 cycles at 0.5 A·g^(-1)).Kinetic investigations show that the N3P1 electrode with the welldeveloped porous structure and large number of surface defects exhibits capacitive-driven behavior at all scan rates,which may be attributed by N and P ***-situ transmission electron microscopy analyses in the fully discharged and charged states demonstrate structural stability and reversibility owing to the expanded interlayer *** suggested synthesis approach is simple and effective for producing heteroatom-doped carbon materials for PIBs and other advanced electrochemical energy storage materials.

关键词： Amorphous carbons 3D porous structures Nitrogen and phosphorous co-doping Potassium-ion batteries

Spin valve effect of NiFe/graphene/NiFe junctions

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Nano Research 2013年第5期6卷 373-379,380页

作者： Muhammad Zahir Iqbal Muhammad Waqas Iqbal Jae hong Lee Yong seung Kim seung-Hyun Chun Jonghwa Eom Department of Physics and Graphene Research Institute Sejong University Seou1143-747 Korea

When spins are injected through graphene layers from a transition metal ferromagnet, high spin polarization can be achieved. When detected by another ferromagnet, the spin-polarized current makes high- and low-resistance states in a ferromagnet/graphene/ferromagnet junction. Here, we report manifest spin valve effects from room temperature to 10 K in junctions comprising NiFe electrodes and an interlayer made of double-layer or single-layer graphene grown by chemical vapor deposition. We have found that the spin valve effect is stronger with double-layer graphene than with single-layer graphene. The ratio of relative magnetoresistance increases from 0.09% at room temperature to 0.14% at 10 K for single-layer graphene and from 0.27% at room temperature to 0.48% at 10 K for double-layer graphene. The spin valve effect is perceived to retain the spin-polarized transport in the vertical direction and the hysteretic nature of magnetoresistance provides the basic functionality of a memory device. We have also found that the junction resistance decreases monotonically as temperature is lowered and the current-voltage characteristics show linear behaviour. These results revealed that a graphene interlayer works not as a tunnel barrier but rather as a conducting thin film between two NiFe electrodes.

关键词： graphene spin valve magnetic junction magnetoresistance spintronics

Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

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World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： Kyoung Sup hong seung Joo Kang Jong Kyoung Choi Ju Han Kim Heewon Seo Suehyun Lee Jae-Woo Jung Hye-Ryun Kang Sang-heon Cho Joo Sung Kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis