Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

作     者：Kyoung Sup Hong Seung Joo Kang Jong Kyoung Choi Ju Han Kim Heewon Seo Suehyun Lee Jae-Woo Jung Hye-Ryun Kang Sang-Heon Cho Joo Sung Kim 

作者机构：Department of Internal MedicineDrug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal MedicineSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical InformaticsSystems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第2期

页      面：258-264页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Basic Science Research Program through a National Research Foundation of Korea Grant Funded by the Ministry of Education,Science,and Technology,No. 2011-0018257 Systems Biomedical Informatics National Core Research Center 

主　　题：Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis 

摘      要：AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2: 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated