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Chronic hepatitis E–an emerging disease in an immunocompromised host

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Gastroenterology Report 2018年第2期6卷 152-155,I0003页

作者： Amitabh Singh Rachna Seth Anand Gupta Shalimar Baibaswata nayak Subrat kumar Acharya Prasenjit Das Department of Paediatrics All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesNew DelhiIndia Department of Pathology All India Institute of Medical SciencesNew DelhiIndia

Chronic hepatitis E virus(HEV)infection is increasingly being reported in immunosuppressed individuals with HIV,patients with haematological malignancy and transplant *** diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic *** treatment benefits of ribavirin in chronic HEV of genotype 1 are not well *** report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute *** report also highlights the successful use of ribavirin for eradicating chronic HEV infection and its subsequent survival *** hepatitis E may be an emerging disease of immunosuppressed patients and should be suspected in the presence of cryptogenic *** is an effective therapy for controlling HEV.

关键词： chronic hepatitis E immunosuppression chronic liver disease ribavirin

Dielectric and electrical properties of Na_(2)Pb_(2)La_(2)W_(2)Ti_(4)Ta_(4)O_(30) electroceramics

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Journal of Advanced Ceramics 2012年第3期1卷 232-240页

作者： P.R.DAS S.BEHERA R.PADHEE P.nayak R.N.P.CHOUDHARY Department of Physics Institute of Technical Education&ResearchSiksha‘O’Anusandhan UniversityBhubaneswar-751030OdishaIndia Department of Physics Hi-tech College EngineeringBhubaneswar-75102OdishaIndia School of Physics Sambalpur UniversityJyoti ViharBurla-768019OdishaIndia

The polycrystalline sample of complex tungsten-bronze type compound(Na_(2)Pb_(2)La_(2)W_(2)Ti_(4)Ta_(4)O_(30))was prepared by a high-temperature solid-state reaction *** temperature preliminary structural study using X-ray diffraction(XRD)data exhibits the formation of a single-phase new *** SEM micrograph of the compound exhibits non uniform rectangular grains distributed throughout the sample *** studies of dielectric parameters(εr,tanδ)as a function of temperature and frequency,and P-E hysteresis(spontaneous polarization)confirmed the existence of ferroelectricity in the *** impedance spectroscopy analysis,carried out as a function of frequency at different temperatures,established a correlation between the microstructure and electrical properties of the *** electrical relaxation process occurring in the material is temperature *** activation energy found from the Arrhenius plot that the conduction process in the material is of mixed *** nature of frequency dependence of ac conductivity suggests that the material obeys Jonscher’s universal power law.

关键词： electronic material ferroelectricity XRD electrical conductivity

Complex impedance properties of LiSr_(2)Nb_(5)O_(15) ceramic

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Journal of Advanced Ceramics 2012年第3期1卷 221-226页

作者： N.K.MOHANTY S.K.SATPATHY Banarji BEHERA P.nayak R.N.P.CHOUDHARY School of Physics Materials Research LaboratorySambalpur UniversityJyoti ViharBurla-768019OdishaIndia Department of Physics ITERS.O.A.UniversityBhubaneswar-751030OdishaIndia

The polycrystalline sample of LiSr2Nb5O15(LSN)was prepared by a high-temperature solid state reaction *** impedance parameters were studied using an impedance analyzer in a wide range of frequencies(102-106 Hz)at different temperatures(28-500℃).Nyquist plot reveals the presence of bulk effect *** bulk resistance of the compound decreases with rise in temperature which shows the negative temperature coefficient of resistance(NTCR)like a *** ac conductivity spectrum was found to obey Jonscher’s universal power *** conductivity(bulk)with temperature demonstrates that the compound exhibits Arrhenius type of electrical conductivity and the activation energy found to be 0.97 eV.

关键词： niobates conductivity complex impedance modulus

Effect of Zn Concentration on Microstructural,Optical,and Hyperfine Properties of Nanocrystalline a-Fe_(2)O_(3)

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 563-568页

作者： N.R.Panda D.Sahu B.S.Acharya P.nayak S.P.Pati D.Das School of Basic Science Indian Institute of Technology BhubaneswarBhubaneswar 751013OdishaIndia School of Physics Sambalpur UniversitySambalpur 768019OdishaIndia School of Chemistry Sambalpur UniversitySambalpur 768019OdishaIndia C.V.Raman College of Engineering Bhubaneswar 752054OdishaIndia Department of Electronic Engineering Tohoku UniversitySendai 980-8579Japan UGC-DAE CSR Sector IIILB-8Bidhan NagarKolkata 700098India

Efforts have been made to prepare nanocomposites of a-Fe2O3-ZnO by wet chemical route with varying concentrations of the *** microstructural properties of the samples are investigated by powder X-ray diffractometry（PXRD） and Transmission electron *** concentration of Zn ions（up to 20 at%） leads to the formation of nanocomposites of a-Fe2O3 and *** of ZnFe2O4 phase is detected by the substitution of higher concentration of Zn2？（30 at%） in the *** average size of the nanoparticles remains in the range of 22–27 nm as obtained from XRD *** results obtained from electron microscopic studies are also close to these *** measurement shows the excitonic peak of ZnO around 390 nm which gets strengthened with Zn *** spectra show the metal–oxygen band below 700 *** temperature Mssbauer studies of the samples show the transition of iron oxide form antiferromagnetic state to paramagnetic state with increasing concentration of Zn2？.Sharp quenching of hyperfine field with Zn concentration is observed as the Hintvalue reduced to zero from 51 T.

关键词： Iron oxide ZnO Electron microscopy Mssbauer study

Low-velocity simultaneous bilateral femoral neck fracture following long-term antiepileptic therapy:A case report

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World Journal of Orthopedics 2019年第10期10卷 371-377页

作者： Mohammed Sadiq Vikrant Kulkarni Syed Azher Hussain Mohammed Ismail Mayur nayak Department of Orthopaedics ESIC Medical College

BACKGROUND Simultaneous bilateral femoral neck fractures are relatively rare *** are usually associated with underlying metabolic bone disorders or systemic ***-term use of narcotics and bisphosphonates can also result in similar fracture patterns;however,association of this fracture type with longterm use of antiepileptic drugs is not very *** one such case has been reported in the *** article describes the *** REPORT We report a case of simultaneous displaced bilateral femoral neck fractures in a 50-year-old epileptic patient,who had taken phenytoin for the past 3 *** fractures were a result of low-velocity injury following a fall from the *** fractures were managed with a bilateral hemi-replacement *** bisphosphonates were given to improve the bone quality in the post-operative *** patient had a good post-operative outcome,that was sustained throughout the entire follow-up period of 1 *** Antiepileptic drugs should be supplemented with bisphosphonates and vitamin D to improve bone quality and prevent fractures in epileptic patients.

关键词： Case report Bilateral femoral neck fracture Antiepileptic drug therapy Druginduced osteopenia Bisphosphonates Vitamin D

Utilization of Swertia chirayita Plant Extracts for Management of Diabetes and Associated Disorders: Present Status, Future Prospects and Limitations

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Natural Products and Bioprospecting 2020年第6期10卷 431-443页

作者： Pinaki Dey Joginder Singh Jagadish Kumar Suluvoy Kevin Joseph Dilip Jayato nayak Department of Biotechnology Karunya Institute of Technology and SciencesCoimbatoreTamil Nadu 641114India Department of Microbiology Lovely Professional UniversityPhagwaraPunjab 144411India Biotechnology Department Vignan Foundation for Science Technology and ResearchGunturAndhra Pradesh 522213India National Dong Hwa University Department of Life SciencesHualienChina Department of Chemical Engineering VSB Engineering CollegeKarurTamil Nadu 639111India

Diabetes mellitus is referred as common metabolic abnormalities characterized as hyperglycemia,mainly caused due to insufficient production of insulin at cellular level or/and defects in insulin *** an endocrine disorder is responsible for serious health problems and its worldwide prevalence is rapidly *** management of diabetes by oral administration of drugs without creating any side effects is still considered a challenging task and increasing cost of con-ventional medicine in developing countries is another matter of *** address these issues,traditional preparations of herbal plant extracts in the form of medicines already gained immense *** chirayita is one among such plants which is known for its hypoglycemic *** chemical constituents with promising pharmacological properties have been identified from such plant extracts but still,such compounds have not been well characterized,specifically against human ***,more research efforts are necessitated to understand exact mechanism of such compounds and to develop overall safety of such plant *** review clearly represents antidiabetic properties of Swertia chirayita extract,strategies to be taken to strengthen its safety application on humans and biotechnological interventions that ensure conservation of such endangered species to promote its future application in modern medicine.

关键词： Swertia chirayita Diabetes Phytochemicals Conservation

Curcuma angustifolia ameliorates carbon tetrachloride-induced hepatotoxicity in HepG2 cells and Swiss albino rats

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 416-424页

作者： Sudipta Jena Asit Ray Diptirani Rath Ambika Sahoo Subhashree Singh Noohi Nasim Durga Madhab Kar Sanghamitra nayak Centre.for Botehology Sisha O Anusandhaon(Demed to be UniesiryKalinga NagorGhatiliaBaubeur-750030 OdishaIndia Depurtment of Phuamoacology School of Pharmoceutical SciencesSissha O"Anusondhan(Demed to be Uniersityh Kalinga NagorGhaikiaBhubonesuoar-751003.Odisha India

Objective:To determine the antioxidant and hepatoprotective potential of methanol extract of rhizome of Curcuma angustifolia(MECA)against carbon tetrachloride(CCl4)-induced hepatic damage in vitro and in ***:DPPH,ABTS and reducing power assays were performed to estimate the antioxidant effect of *** vitro cytotoxicity of MECA against HepG2 cells was evaluated,whereas serum biochemical parameters and levels of antioxidative enzymes were measured in vivo and in ***,histopathological studies were estimated in order to investigate the hepatoprotective efficacy of ***,GC-MS analysis of the extract was performed to identify the chemical ***:MECA exhibited strong antioxidant activity and attenuated CCl4-induced decrease in the viability of HepG2 ***,MECA significantly restored the ALT,AST,ALP,TP and albumin level in comparison with the CCl4 *** pre-treatment with MECA,effects of SOD,CAT and GSH were increased as well as lipid peroxidation amount decreased on CCl4-induced hepatotoxicity in in vitro and in vivo ***,histopathological observation confirmed that MECA reduced liver injury induced by CCl4 in ***-MS analysis confirmed the presence of bioactive constituents such as α-tocopherol(12.27%),phytol(7.61%),squalene(3.71%),β-sitosterol(2.19%),eugenol(2.59%),curcumenol(1.20%),β-elemene(1.00%)and eucalyptol(0.89%).Conclusions:MECA contains antioxidant and hepatoprotective constituents such asα-tocopherol,phytol,squalene and eugenol and exerts hepatoprotective effect both in vitro and in vivo.

关键词： Curcuma angustifolia Hepatoprotective activity Carbon tetrachloride Antioxidant activity HepG2 cells

TBDDoSA-MD:Trust-Based DDoS Misbehave Detection Approach in Software-defined Vehicular Network(SDVN)

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Computers, Materials & Continua 2021年第12期69卷 3513-3529页

作者： Rajendra Prasad nayak Srinivas Sethi Sourav Kumar Bhoi Kshira Sagar Sahoo Nz Jhanjhi Thamer A.Tabbakh Zahrah A.Almusaylim Department of CSE Government College of Engineering(BPUT UniversityRourkela)Kalahandi766002India Department of CSE Indira Gandhi Institute of Technology(BPUT University Rourkela) Sarang759146India Department of CSE Parala Maharaja Engineering College(BPUT University Rourkela)Berhampur761003India Department of CSE SRM UniversityAmaravati522502APIndia School of Computer Science and Engineering Taylor’s UniversitySubang Jaya47500Malaysia Material Research Science Institute King Addulaziz City for Science and Technology(KACST)Riyad6086Kingdom of Saudi Arabia King Addulaziz City for Science and Technology(KACST) Riyad6086Kingdom of Saudi Arabia

Reliable vehicles are essential in vehicular networks for effective *** vehicles in the network are dynamic,even a short span of misbehavior by a vehicle can disrupt the whole network which may lead to catastrophic *** this paper,a Trust-Based Distributed DoS Misbehave Detection Approach(TBDDoSA-MD)is proposed to secure the Software-Defined Vehicular Network(SDVN).A malicious vehicle in this network performs DDoS misbehavior by attacking other vehicles in its *** uses the jamming technique by sending unnecessary signals in the network,as a result,the network performance *** vehicles in that network will no longer meet the service requests from other ***,in this paper,we proposed an approach to detect the DDoS misbehavior by using the trust values of the *** values are calculated based on direct trust and recommendations(indirect trust).These trust values help to decide whether a vehicle is legitimate or *** simply discard the messages from malicious vehicles whereas the authenticity of the messages from legitimate vehicles is checked further before taking any action based on those *** performance of TBDDoSA-MD is evaluated in the Veins hybrid simulator,which uses OMNeT++and Simulation of Urban Mobility(SUMO).We compared the performance of TBDDoSA-MD with the recently proposed Trust-Based Framework(TBF)scheme using the following performance parameters such as detection accuracy,packet delivery ratio,detection time,and energy *** results show that the proposed work has a high detection accuracy of more than 90%while keeping the detection time as low as 30 s.

关键词： Software-defined vehicular network trust evaluator node denial of service misbehavior

Calcarea carbonica treatment rescues lipopolysaccharide-induced inflammatory response in human mononuclear cells via downregulation of inducible cyclooxygenase pathway

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Journal of Integrative Medicine 2020年第5期18卷 441-449页

作者： Swatantra Kumar Vimal KMaurya Debadatta nayak Anil Khurana Raj KManchanda Srinivasulu Gadugu Madan LBBhatt Shailendra K.Saxena Centre for Advanced Research Faculy of MedicineKing George's Medical UniversityLucknow 226003India Central Council for Research in Homoeopathty.Ministry of Ayush.Janakpuri.New Delhi 10058 India Deparment of Medicine Jaisoorya and Potti Sreeramulu Government Medical Cllege.Hyderabad 500013India

Objective: Prolonged use of nonsteroidal anti-inflammatory drugs is associated with severe side effects and toxicity. Therefore, we studied the anti-inflammatory role of Calcarea carbonica which had minimal toxicity at the low ***: THP-1 human mononuclear cells were treated with C. carbonica to evaluate the 50% cytotoxicity concentration(CC_(50)) and 50% effective concentration(EC_(50)). Cell survival was evaluated in lipopolysaccharide-stimulated C. carbonica-treated cells. Nitric oxide(NO) and tumor necrosis factor-a(TNF-a) were measured to evaluate the anti-inflammatory activity of C. carbonica. Cyclooxygenase-2(COX-2) protein expression was determined by Western blotting analysis, and the interaction of C. carbonica with the COX-2 protein was evaluated using molecular docking ***: The CC_(50) and EC_(50) of C. carbonica were found to be 43.26 and 11.99 mg/mL, respectively. The cell survival assay showed a 1.192-fold(P = 0.0129), 1.443-fold(P = 0.0009) and 1.605-fold(P = 0.0004)increase in cell survival at 24, 48 and 72 h after initiating C. carbonica treatment, respectively. C. carbonica-treated cells showed a reduction in NO levels by 2.355 folds(P = 0.0001), 2.181 folds(P = 0.0001) and 2.071 folds(P = 0.0001) at 24, 48 and 72 h, respectively. The treated cells also showed a reduction in TNFa levels by 1.395 folds(P = 0.0013), 1.541 folds(P = 0.0005) and 1.550 folds(P = 0.0005) at 24, 48 and72 h, respectively. In addition, a 1.193-fold reduction(P = 0.0126) in COX-2 protein expression was found in C. carbonica-treated cells. The molecular docking showed interaction of C. carbonica with the phenylalanine 367 residue present in active site of ***: C. carbonica exhibited anti-inflammatory properties in lipopolysaccharide-stimulated cells by significantly reducing NO production and TNF-a level through downregulation of the COX-2 protein. This effect is probably mediated through interaction of C. carbonica with the phenylalanine

关键词： Inflammation Calcarea carbonica Cyclooxygenase-2 Nitric oxide Tumor necrosis factor-a Anti-inflammatory