检索结果-南通市图书馆

Ultrasound diagnosis of diverticulitis

在线全文

学校读者我要写书评

暂无评论

World Journal of emergency Medicine 2016年第1期7卷 74-76页

作者： Michael e. Abboud sarah e. Frasure Michael B. Stone emergency Department Harvard University 45 Francis St Neville House - 236A Boston Massachusetts 02115 USA

Diverticular disease accounts for approximately 312 000 hospital admissions in the United States annually, and costs nearly 2.6 billion dollars. Approximately 20% of Americans with diverticular disease will experience at least one episode of acute diverticulitis, necessitating a visit to their physician＇s office or the emergency department （eD） for *** As the risk of developing diverticulitis rises with age （nearly 50% of people aged over 60 years have colonic diverticula）, the incidence is rising as the elderly population grows.

关键词： will oral

The presence and partitioning behavior of flame retardants in waste,leachate,and air particles from Norwegian waste-handling facilities

在线全文

学校读者我要写书评

暂无评论

Journal of environmental Sciences 2017年第12期29卷 115-132页

作者： Nicolas A.O.Morin Patrik L.Andersson sarah e.Hale Hans Peter H.Arp Norwegian Geotechnical Institute(NGI) P.O.Box 3930Ulleval StadionN-0806 OsloNorway environmental and Food Laboratory of Vendee(LeA V) Department of ChemistryRond-point Georges Dural CS 8080285021 La Roche-sur-YonFrance Chemistry Department Umed UniversitySE-901 87 UmeaSweden

Flame retardants in commercial products eventually make their way into the waste *** the presence of flame retardants in Norwegian landfills, incineration facilities and recycling sorting/defragmenting facilities is investigated. These facilities handled waste electrical and electronic equipment（Weee）, vehicles, digestate, glass, combustibles, bottom ash and fly ash. The flame retardants considered included polybrominated diphenyl ethers（∑BDe-10） as well as dechlorane plus, polybrominated biphenyls, hexabromobenzene,pentabromotoluene and pentabromoethylbenzene（collectively referred to as ∑FR-7）. Plastic,Weee and vehicles contained the largest amount of flame retardants（∑BDe-10： 45,000–210,000 μg/kg; ∑FR-7： 300–13,000 μg/kg）. It was hypothesized leachate and air concentrations from facilities that sort/defragment Weee and vehicles would be the highest. This was supported for total air phase concentrations（∑BDe-10： 9000–195,000 pg/m^3 Weee/vehicle facilities, 80–900 pg/m^3 in incineration/sorting and landfill sites）, but not for water leachate concentrations（e.g., ∑BDe-10： 15–3500 ng/L in Weee/Vehicle facilities and 1–250 ng/L in landfill sites）. Landfill leachate exhibited similar concentrations as Weee/vehicle sorting and defragmenting facility leachate. To better account for concentrations in leachates at the different facilities, waste-water partitioning coefficients, Kwastewere measured（for the first time to our knowledge for flame retardants）. Weee and plastic waste had elevated Kwastecompared to other wastes, likely because flame retardants are directly added to these materials. The results of this study have implications for the development of strategies to reduce exposure and environmental emissions of flame retardants in waste and recycled products through improved waste management practices.

关键词： Brominated flame retardants Waste management environmental emissions Atmospheric emissions Partitioning Leachate

Teamwork Optimization with Deep Learning Based Fall Detection for IoT-enabled Smart Healthcare System

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第4期75卷 1353-1369页

作者： sarah B.Basahel Saleh Bajaba Mohammad Yamin Sachi Nandan Mohanty e.Laxmi Lydia Department of Management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddahSaudi Arabia Department of business Administration Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Management Information Systems Faculty of Economics and AdministrationKing Abdulaziz UniversityJeddah21589Saudi Arabia School of Computer Science&engineering(SCOPe) VIT-AP UniversityAmaravatiAndhra PradeshIndia Department of Computer Science and engineering GMR Institute of TechnologyAndhra PradeshRajam 532127India

The current advancement in cloud computing,Artificial Intelligence(AI),and the Internet of Things(IoT)transformed the traditional healthcare system into smart *** services could be enhanced by incorporating key techniques like AI and *** convergence of AI and IoT provides distinct opportunities in the medical *** is regarded as a primary cause of death or post-traumatic complication for the ageing ***,earlier detection of older person falls in smart homes is required to improve the survival rate of an individual or provide the necessary ***,the emergence of IoT,AI,smartphones,wearables,and so on making it possible to design fall detection(FD)systems for smart home *** article introduces a new Teamwork Optimization with Deep Learning based Fall Detection for IoT enabled Smart Healthcare Systems(TWODLFDSHS).The TWODL-FDSHS technique’s goal is to detect fall events for a smart healthcare ***,the presented TWODL-FDSHS technique exploits IoT devices for the data collection ***,the TWODLFDSHS technique applies the TWO with Capsule Network(CapsNet)model for feature *** last,a deep random vector functional link network(DRVFLN)with an Adam optimizer is exploited for fall event detection.A wide range of simulations took place to exhibit the enhanced performance of the presentedTWODL-FDSHS *** experimental outcomes stated the enhancements of the TWODL-FDSHS method over other models with increased accuracy of 98.30%on the URFD dataset.

关键词： Internet of things smart healthcare deep learning team work optimizer capsnet fall detection

Saving time and effort:Best practice for adapting existing patientreported outcome measures in hepatology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第5期14卷 896-910页

作者： Laith Alrubaiy Hayley A Hutchings sarah e Hughes Thomas Dobbs Department of Gastroenterology St Mark's HospitalLondon HA13UJUnited Kingdom Institute of Life Sciences 2 Swansea University Medical SchoolSingleton ParkSwansea SA28PPUnited Kingdom Swansea University Medical School Swansea UniversitySwansea SA28PPUnited Kingdom Centre for Patient Reported Outcome Research Institute of Applied Health ResearchUniversity of BirminghamBirmingham B152TTUnited Kingdom Swansea University Swansea SA28PPUnited Kingdom

It is increasingly recognised that collecting patient reported outcome measures(PROMs)data is an important part of healthcare and should be considered alongside traditional clinical *** part of a more holistic view of healthcare provision,there has been an increased drive to implement PROM collection as part of routine clinical care in *** drive has resulted in an increase in the number of PROMs currently developed to be used in various liver ***,the development and validation of a new PROM is time-consuming and ***,before deciding to develop a new PROM,researchers should consider identifying existing PROMs to assess their appropriateness and,if necessary,make adaptations to existing PROMs to ensure their rigour when used with the target *** is written in the literature on how to identify and adapt the existing PROMs in *** article aims to provide a summary of the current literature and guidance regarding identifying and adapting existing PROMs in clinical practice.

关键词： Patient reported outcome measures Adaptation Content validation Hepatology Patient reported outcomes

Resistance mechanisms in melanoma to immuneoncologic therapy with checkpoint inhibitors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2019年第3期2卷 744-761页

作者： sarah e.Fenton Jeffrey A.Sosman Sunandana Chandra Division of Hematology Oncology Northwestern UniversityChicagoIL 60611USA.

Checkpoint inhibitors act by blocking physiologic mechanisms coopted by tumor cells to evade immune surveillance,restoring the immune system’s ability to identify and kill malignant *** therapies have dramatically improved outcomes in multiple tumor types with durable responses in many patients,leading to FDA approval first in advanced melanoma,then in many other ***,as experience with checkpoint inhibitors has grown,populations of patients who are primary nonresponders or develop secondary resistance have been the majority of cases,even in *** of resistance include those inherent to the tumor microenvironment,the tumor cells themselves,and the function of the patient’s native immune *** review will discuss resistance to checkpoint inhibitors in melanoma as well as possible methods to restore sensitivity.

关键词： Melanoma checkpoint inhibitor resistance nonresponder secondary resistance

Perspective: plasticity, the enemy of the good

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2019年第2期2卷 351-355页

作者： sarah Yvonnet Anouk Barberousse Alexandre e.escargueil Sorbonne Université CNRSLaboratory SciencesNormesDémocratie(SND)Paris F-75005France Sorbonne Université INSERMLaboratory Cancer Biology and TherapeuticsCentre de Recherche Saint-AntoineCRSAParis F-75012France.

Plasticity is an important feature of modern cancer ***,the level at which we should consider it remains an open *** debate is not new in the field of cancer and can be exemplified by the different models explaining *** models mostly explain cell transformation through the deregulation of the internal *** the last years,those models dramatically increased our knowledge and led to a series of short-term successes in terms of ***,cancer drug resistance inevitably ***,studies on the so-called tumor microenvironment enriched the cell-centered perspective but it also enlarged the complexity of cancer etiology in particular for advanced ***,we suggest that the plastic and multi-sites specific nature of cancer combined with our incapacity to promise cure should push towards a new perspective where early clinical actions,instead of late ones,should be heralded as the priority of cancer research and care.

关键词： Resistance plasticity metastasis timeline clinical action

Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in eR-positive breast cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第6期13卷 433-444页

作者： Lei Duan sarah Calhoun Daeun Shim Ricardo e.Perez Lothar A.Blatter Carl G.Maki Department of Cell and Molecular Medicine Rush University Medical CenterChicagoIL 60612USA Department of Molecular Biophysics and Physiology Rush University Medical CenterChicagoIL 60612USA

Tamoxifen(TAM)is the first-line endocrine therapy for estrogen receptor-positive(eR+)breast cancer(BC).However,acquired resistance occurs in∼50%***,although the PI3K/AKT/mTOR pathway is a viable target for treatment of endocrine therapy-refractory patients,complex signaling feedback loops exist,which can counter the effectiveness of inhibitors of this ***,we analyzed signaling pathways and metabolism in eR+MCF7 BC cell line and their TAM-resistant derivatives that are co-resistant to endoxifen using immunoblotting,quantitative polymerase chain reaction,and the Agilent Seahorse XF *** found that activation of AKT and the energy-sensing kinase AMPK was increased in TAM and endoxifen-resistant ***,eRRα/PGC-1βand their target genes MCAD and CPT-1 were increased and regulated by AMPK,which coincided with increased fatty acid oxidation(FAO)and autophagy in TAM-resistant *** of AKT feedback-activates AMPK and eRRα/PGC-1β-MCAD/CPT-1 with a consequent increase in FAO and autophagy that counters the therapeutic effect of endoxifen and AKT ***,our results indicate increased activation of AKT and AMPK with metabolic reprogramming and increased autophagy in TAM-resistant *** inhibition of AKT and FAO/autophagy is necessary to fully sensitize resistant cells to endoxifen.

关键词： endoxifen fatty acid oxidation autophagy AMPK AKT

Arabidopsis thaliana T-DNA Mutants Implicate GAUT Genes in the Biosynthesis of Pectin and Xylan in Cell Walls and Seed Testa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2009年第5期2卷 1000-1014页

作者： Kerry H. Caffall Sivakumar Pattathil sarah e. Phillips Michael G. Hahn Debra Mohnen Department of Biochemistry and Molecular Biology University of Georgia Athens GA 30602 USA Complex Carbohydrate Research Center BioEnergy Science Center 315 Riverbend Road University of Georgia Athens GA 30602 USA Department of Plant Biology University of Georgia Athens GA 30602 USA

Galacturonosyltransferase 1 （GAUT1） is an α1,4-D-galacturonosyltransferase that transfers galacturonic acid from uridine 5＇-diphosphogalacturonic acid onto the pectic polysaccharide homogalacturonan （Sterling et al., 2006）. The 25-member Arabidopsis thaliana GAUT1-related gene family encodes 15 GAUT and 10 GAUT-like （GATL） proteins with, respectively, 56-84 and 42-53% amino acid sequence similarity to GAUT1. Previous phylogenetic analyses of AtGAUTs indicated three clades： A through C. A comparative phylogenetic analysis of the Arabidopsis, poplar and rice GAUT families has sub-classified the GAUTs into seven clades： clade A-1 （GAUTs 1 to 3）; A-2 （GAUT4）; A-3 （GAUTs 5 and 6）; A-4 （GAUT7）; B-1 （GAUTs 8 and 9）; B-2 （GAUTs 10 and 11）; and clade C （GAUTs 12 to 15）. The Arabidopsis GAUTs have a distribution comparable to the poplar orthologs, with the exception of GAUT2, which is absent in poplar. Rice, however, has no orthologs of GAUTs 2 and 12 and has multiple apparent orthologs of GAUTs 1, 4, and 7 compared with eitherArabidopsis or poplar. The cell wall glycosyl residue compositions of 26 homozygous T-DNA insertion mutants for 13 of 15 Arabidopsis GAUTgenes reveal significantly and reproducibly different cell walls in specific tissues of gaut mutants 6, 8, 9, 10, 11, 12, 13, and 14 from that of wild-type Arabidopsis walls. Pectin and xylan polysaccharides are affected by the loss of GAUT function, as demonstrated by the altered galacturonic acid, xylose, rhamnose, galactose, and arabinose composition of distinct gaut mutant walls. The wall glycosyl residue compositional phenotypes observed among the gaut mutants suggest that at least six different biosynthetic linkages in pectins and/or xylans are affected by the lesions in these GAUTgenes. evidence is also presented to support a role for GAUT11 in seed mucilage expansion and in seed wall and mucilage composition.

关键词： Carbohydrate metabolism cell walls Arabidopsis biosynthesis mutant pectin mucilage

Novel technique of insulin loading into porous carriers for oral delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2018年第4期13卷 297-309页

作者： sarah Y.eilleia Mahmoud e.Soliman Samar Mansour Ahmed.S.Geneidi Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyAin Shams University

The increasing demand for oral macromolecule delivery encouraged the development of mi-croencapsulation technologies to protect such drugs against gastric and enzymatic degra-dation. However, microencapsulation often requires harsh conditions that may jeopardizetheir biological activity. Accordingly, many trials attempted to load macromolecules intoporous drug carriers to bypass any formulation induced instability. In this study, we pre-pared chitosan coated porous poly(d, l-lactide-co-glycolide)(PLGA) microparticles(MPs)loaded with insulin using a novel loading technique; double freeze-drying. The resultsshowed a significant increase in drug loading using only 5 mg/ml initial insulin concen-tration and conveyed a sustained drug release over uncoated MPs. Furthermore, SeM andconfocal microscopy confirmed pore blocking and insulin accumulation within the MPs re-spectively. The oral pharmacodynamic data on rats also proved the preservation of insulinbioactivity after formulation. Finally, the new coating technique proved to be efficient inproducing robust layer of chitosan with higher insulin loading while maintaining insulinactivity.

关键词： Porous microparticles PLGA Insulin Freeze-drying Chitosan coating