Perspective: plasticity, the enemy of the good
作者机构：Sorbonne UniversitéCNRSLaboratory SciencesNormesDémocratie(SND)Paris F-75005France Sorbonne UniversitéINSERMLaboratory Cancer Biology and TherapeuticsCentre de Recherche Saint-AntoineCRSAParis F-75012France.
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第2期
页 面：351-355页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Sarah Yvonnet is supported by a fellowship from the PhD program in Oncology of the“Institut Universitaire de Cancérologie” Sorbonne Université
主 题：Resistance plasticity metastasis timeline clinical action
摘 要：Plasticity is an important feature of modern cancer ***,the level at which we should consider it remains an open *** debate is not new in the field of cancer and can be exemplified by the different models explaining *** models mostly explain cell transformation through the deregulation of the internal *** the last years,those models dramatically increased our knowledge and led to a series of short-term successes in terms of ***,cancer drug resistance inevitably ***,studies on the so-called tumor microenvironment enriched the cell-centered perspective but it also enlarged the complexity of cancer etiology in particular for advanced ***,we suggest that the plastic and multi-sites specific nature of cancer combined with our incapacity to promise cure should push towards a new perspective where early clinical actions,instead of late ones,should be heralded as the priority of cancer research and care.
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