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Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

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World Journal of Transplantation 2024年第2期14卷 62-75页

作者： Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino sanjaya k satapathy Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hepatology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACkGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),P<0.001].The frequency of transplant rejections among hospitalized LT recipients increased from 0.2%to 3.6% between January 2019 and December *** hospitalizations during the COVID-19 pandemic had a higher associ

关键词： Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality

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Impact of metabolic dysfunction-associated steatotic liver disease on COVID-19 hospitalizations:A propensity-matched analysis of the United States

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World Journal of Virology 2024年第1期13卷 51-60页

作者： Abdullah Sohail Hassam Ali Pratik Patel Subanandhini Subramanium Dushyant Singh Dahiya Amir H Sohail Manesh kumar Gangwani sanjaya k satapathy Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY11777United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Section on Gastroenterology and Hepatology North Shore University Hospital and Long Island Jewish Medical CenterManhassetNY 11030United States

BACkGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),formally known as nonalcoholic fatty liver disease,is the most common chronic liver disease in the United *** with MASLD have been reported to be at a higher risk of developing severe coronavirus disease 2019(COVID-19)and ***,most studies are single-center studies,and nationwide data in the AIM To study the influence of MASLD on COVID-19 hospitalizations during the initial phase of the *** We retrospectively analyzed the 2020 National Inpatient Sample(NIS)database to identify primary COVID-19 hospitalizations based on an underlying diagnosis of MASLD.A matched comparison cohort of COVID-19 hospit-alizations without MASLD was identified from NIS after 1:N propensity score matching based on gender,race,and comorbidities,including hypertension,heart failure,diabetes,and *** primary outcomes included inpatient mortality,length of stay,and hospitalization *** outcomes included the prevalence of systemic *** A total of 2210 hospitalizations with MASLD were matched to 2210 hospitalizations without MASLD,with a good comorbidity ***,there was a higher prevalence of severe disease with more intensive care unit admissions(9.5%vs 7.2%,P=0.007),mechanical ventilation(7.2%vs 5.7%,P=0.03),and septic shock(5.2%vs 2.7%,P<0.001)in the MASLD cohort than in the non-MASLD ***,there was no difference in mortality(8.6%vs 10%,P=0.49),length of stay(5 d vs 5 d,P=0.25),and hospitalization costs(42081.5$vs 38614$,P=0.15)between the MASLD and non-MASLD *** The presence of MAFLD with or without liver cirrhosis was not associated with increased mortality in COVID-19 hospitalizations;however,there was an increased incidence of severe COVID-19 *** data(2020)predates the availability of COVID-19 vaccines,and many MASLD patients have since been *** will be interesting to see if these trends are

关键词： COVID-19 Metabolic dysfunction-associated steatotic liver disease Prevalence Hospital charges Inpatient resource utilization

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Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)

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World Journal of Virology 2024年第1期13卷 69-83页

作者： Hassam Ali Fnu Vikash Vishali Moond Fatima khalid Abdur Rehman Jamil Dushyant Singh Dahiya Amir Humza Sohail Manesh kumar Gangwani Pratik Patel sanjaya k satapathy Department of Internal Medicine/Gastroenterology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Internal Medicine Saint Peter's University Hospital/Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Department of Internal Medicine Quaid-e-Azam Medical CollegeBahawalpur 63100PunjabPakistan Department of Internal Medicine Samaritan Medical CentreWatertownMA 13601United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery New York University Winthrop HospitalNew YorkMineloaNY 11501United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY 11777United States Division of Hepatology Department of MedicineNorth Shore University HospitalManhassetNY 11030United States

BACkGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical *** the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis ***,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease's global *** some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender *** gap in knowledge hinders the development of targeted interventions and resource allocation *** The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two ***,females exhibited a remarkable decrease in mortality compared to ***,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward *** America and the Caribbean also experienced an increase in mortality ***,no significant difference was observed in the Middle East and North *** America exhibited a notable upward *** Asia and Sub-Saharan Africa significantly declined throughout the study *** raises the hope of identifying areas for implementing more targeted *** some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24].

关键词： Carcinoma Hepatocellular Antiviral agents Global Burden of Disease Quality indicators Health care Liver neoplasms Hepatitis C Chronic hepatitis C

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Racial and gender-based disparities and trends in common psychiatric conditions in liver cirrhosis hospitalizations:A ten-year United States study

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World Journal of Hepatology 2023年第2期15卷 289-302页

作者： Pratik Patel Hassam Ali Faisal Inayat Rahul Pamarthy Alexa Giammarino Fariha Ilyas Lucia Angela Smith-Martinez sanjaya k satapathy Department of Gastroenterology Mather Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahore 54550PunjabPakistan Department of Internal Medicine North Shore University Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Psychiatry East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Hepatology North Shore University Hospital and Hofstra University Zucker School of MedicineManhassetNY 11030United States

BACkGROUND Chronic liver disease is associated with various neuropsychiatric *** are currently no large studies assessing and comparing the prevalence of psy-chiatric illnesses based on patient profiles and the etiology of *** To examine the trends of hospitalizations among psychiatric conditions in *** We used the National Inpatient Sample database 2016-2019 for the primary diagnosis of liver *** outcomes included the prevalence,trends,and associations of psychiatric diagnoses in these ***-square for categorical variables and the Wilcoxon rank test for continuous variables were *** The prevalence of generalized anxiety disorder(GAD)in liver cirrhosis hospitalizations increased from 0.17%in 2009 to 0.92%in 2019(Pk to psychiatric *** had a higher association with GAD(aOR 2.56,95%CI 2.14-3.06,P<0.001),depression(aOR 1.78,95%CI 1.71-1.84,P<0.001),bipolar disorder(aOR 1.64,95%CI 1.52-1.77,P<0.001]and chronic fatigue(aOR 2.31,95%CI 1.31-4.07,P<0.001)when compared to ***,Hispanics,and Asian/Native Americans had a significantly lower association with GAD,depression,bipolar disorder,PTSD,and ADHD wh

关键词： Liver cirrhosis hospitalizations Psychiatric conditions Racial and gender disparities

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New onset diabetes mellitus after liver transplantation

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 724-727页

作者： Benedict Maliakkal sanjaya k.satapathy Ascension St.Thomas Hospital NashvilleTNUSA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Northwell HealthHempsteadNYUSA

The recently published article,“New-onset diabetes after adult liver transplantation in the korean Organ Transplantation Registry(kOTRY)study”by Man kim et *** generated significant renewed interest in New Onset Diabetes after Transplant(NODAT)(1).NODAT was defined by International Consensus(2003)and by American Diabetes Association by the same criteria as Type 1/Type 2 *** after liver or another solid organ transplantation(SOT)on antidiabetic medication for more than one month or who fulfills one of these criteria on stable immunosuppression is deemed to have NODAT:(I)fasting blood sugar(FBS)>7 mmol(126 mg/dL)。

关键词： diabetes liver

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Nonalcoholic Fatty Liver Disease(NAFLD)Name Change:Requiem or Reveille?

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 931-938页

作者： Shivaram P.Singh Prajna Anirvan Reshu khandelwal sanjaya k.satapathy Department of Gastroenterology Sriram Chandra Bhanj Medical CollegeCuttackOdishaIndia Division of Hepatology Sandra Atlas Bass Center for Liver Diseases and TransplantationDonald and Barbara Zucker School of Medicine at Hofstra/Northwell HealthManhassetNYUSA

Nonalcoholic fatty liver disease(NAFLD)affects about a quarter of the world’s population and poses a major health and economic burden ***,there have been hasty attempts to rename NAFLD to metabolic-associated fatty liver disease(MAFLD)despite the fact that there is no scientific rationale for *** for a“positive criterion”to diagnose the disease and destigmatizing the disease have been the main reasons put forth for the name change.A close scrutiny of the pathogenesis of NAFLD would make it clear that NAFLD is a heterogeneous disorder,involving different pathogenic mechanisms of which metabolic dysfunction-driven hepatic steatosis is only *** NAFLD with MAFLD would neither enhance the legitimacy of clinical practice and clinical trials,nor improve clinical care or move NAFLD research *** than changing the nomenclature without a strong scientific backing to support such a change,efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options.

关键词： Heterogeneity MAFLD Metabolic NAFLD NASH Nomenclature Steatohepatitis

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Hepatocellular carcinoma in non-alcoholic steatohepatitis:Current knowledge and implications for management

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World Journal of Hepatology 2017年第11期9卷 533-543页

作者： George Cholankeril Ronak Patel Sandeep khurana sanjaya k satapathy Division of Gastroenterology and Hepatology Methodist University Hospital Transplant Institute University of Tennessee Health Sciences Center Department of Medicine University of Alabama at Birmingham Montgomery Health Center Division of Gastroenterology Georgia Regents University

With the prevalence of hepatitis C virus expected to decline, the proportion of hepatocellular carcinoma(HCC) related to non-alcoholic steatohepatitis(NASH) is anticipated to increase exponentially due to the growing epidemic of obesity and diabetes. The annual incidence rate of developing HCC in patients with NASH-related cirrhosis is not clearly understood with rates ranging from 2.6%-12.8%. While multiple new mechanisms have been implicated in the development of HCC in NASH; further prospective long-term studies are needed to validate these findings. Recent evidence has shown a significant proportion of patients with non-alcoholic fatty liver disease and NASH progress to HCC in the absence of cirrhosis. Liver resection and transplantation represent curative therapeutic options in select NASHrelated HCC patients but have placed a significant burden to our healthcare resources and utilization. Currently NASH-related HCC is the fastest growing indication for liver transplant in HCC candidates. Increased efforts to implement effective screening and preventative strategies, particularly in non-cirrhotic NASH patients, are needed to reduce the future impact imposed by NASH-related HCC.

关键词：非酒精的 steatohepatitis 肝硬化非酒精的脂肪肝疾病肥胖 Hepatocellular 癌

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Association of non-alcoholic fatty liver disease and COVID-19: A literature review of current evidence

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World Journal of Hepatology 2021年第8期13卷 916-925页

作者： Prajna Anirvan Shivaram P Singh Alexa Giammarino sanjaya k satapathy Department of Gastroenterology Sriram Chandra Bhanj Medical College and HospitalCuttack 753007OdishaIndia Department of Internal Medicine Donald and Barbara Zucker School of Medicine at HofstraManhassetNY 11030United States Division of Hepatology at Sandra Atlas Bass Center for Liver Diseases and Transplantation Donald and Barbara Zucker School of Medicine at HofstraManhassetNY 11030United States

The coronavirus disease 2019(COVID-19)pandemic has swept through nations,crippled economies and caused millions of deaths *** people diagnosed with COVID-19 infections are often found to develop liver injury,which,in a small portion of patients,progresses to severe liver *** injury in the form of elevated transaminases,hyperbilirubinemia and alterations in serum albumin has been observed to be higher in patients with severe forms of the *** who already have insult to the liver from chronic disease,such as nonalcoholic fatty liver disease(NAFLD)may be at the greatest *** severity of COVID-19 also seems to be driven by the presence of NAFLD and other *** 25%of the global population has *** such a widespread prevalence of NAFLD,understanding the disease progression of COVID-19 and the occurrence of liver injury in this vulnerable population assumes great *** this review,we present an overview of COVID-19 infection in patients with NAFLD.

关键词： SARS-CoV-2 Fatty liver Mitochondria Nitrosative stress Oxidative stress COVID-19 Metabolic associated fatty liver disease Nonalcoholic fatty liver disease Progressive liver disease Nonalcoholic steatohepatitis

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Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： David Bernstein Nitzan Roth Angela kim Marica Epstein David Hirschwerk Charlotte L kvasnovsky sanjaya k satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACkGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 Liver enzymes Outcomes Predictors

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NAFLD Epidemiology, Emerging Pharmacotherapy, Liver Transplantation Implications and the Trends in the United States

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 215-221页

作者： Chiranjeevi Gadiparthi Moshe Spatz Simi Greenberg Umair Iqbal Sowjanya kanna sanjaya k satapathy Arkady Broder Aijaz Ahmed Division of Gastroenterology Hepatology and Clinical NutritionSaint Peter’s University HospitalNew BrunswickNJUSA Rutgers Robert Wood Johnson Medical School PiscatawayNJUSA Nova Southeastern University College of Osteopathic Medicine DavieFLUSA Geisinger Commonwealth School of Medicine DanvillePAUSA Division of Gastroenterology Allegheny Health NetworkTarentumPAUSA Northwell Health Division of Hepatology&Sandra Atlas Bass Center for Liver DiseasesManhassetNYUSA Stanford University School of Medicine Division of Gastroenterology and HepatologyStanfordCAUSA

Nonalcoholic fatty liver disease (NAFLD) is a hepatic mani-festation of metabolic syndrome. The spread of obesity worldwide in pandemic proportions has led to a rapid rise of NAFLD in developed and developing countries alike. There are no approved pharmacological agents to treat steatohepatitis or advanced fibrosis but obeticholic acid recently has shown some promise in phase III trial. Currently, NAFLD is the number one etiology for simultaneous liver and kidney trans-plantation in the USA, second most common indication for liver transplantation (LT) and projected to become number one very soon. LT for NAFLD poses unique challenges, as these patients are generally older, obese and more likely to have a number of metabolic risk factors. Bariatric surgery is an option and can be considered if a structured weight loss program does not achieve the sustained weight loss goal. Comprehensive cardiovascular risk assessment and aggres-sive management of comorbid conditions are crucial in the LT evaluation process to improve post-transplant survival. Re-current nonalcoholic steatohepatitis after LT is not uncom-mon, and thus warrants primary and secondary prevention strategies through a multidisciplinary approach. Prevalence of NAFLD in a donor population is a unique and growing concern that limits the access to quality liver grafts.

关键词： NAFLD NAFL NASH Liver transplantation

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