Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease
作者机构：Department of Medicine/HepatologyNorthwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious DiseasesDepartment of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical CenterZucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第42期
页 面：7350-7361页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：by National Institute on Aging of the National Institute of Health,No.R24AG06419 National Library of Medicine of the National Institutes of Health,No.R01LM012836
主 题：COVID-19 Liver enzymes Outcomes Predictors
摘 要：BACKGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.
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