Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)

作     者：Hassam Ali Fnu Vikash Vishali Moond Fatima Khalid Abdur Rehman Jamil Dushyant Singh Dahiya Amir Humza Sohail Manesh Kumar Gangwani Pratik Patel Sanjaya K Satapathy 

作者机构：Department of Internal Medicine/GastroenterologyEast Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal MedicineJacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Internal MedicineSaint Peter's University Hospital/Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Department of Internal MedicineQuaid-e-Azam Medical CollegeBahawalpur 63100PunjabPakistan Department of Internal MedicineSamaritan Medical CentreWatertownMA 13601United States Division of GastroenterologyHepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of SurgeryNew York University Winthrop HospitalNew YorkMineloaNY 11501United States Department of Internal MedicineThe University of ToledoToledoOH 43606United States Department of GastroenterologyMather Hospital/Hofstra University Zucker School of MedicineNY 11777United States Division of HepatologyDepartment of MedicineNorth Shore University HospitalManhassetNY 11030United States 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2024年第13卷第1期

页      面：69-83页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The present study did not require institutional review board oversight because Global Burden of Disease Study 2019 database is de-identified and freely accessible.It does not identify hospitals health care providers or patients 

主　　题：Carcinoma Hepatocellular Antiviral agents Global Burden of Disease Quality indicators Health care Liver neoplasms Hepatitis C Chronic hepatitis C 

摘      要：BACKGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical *** the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis ***,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease s global *** some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender *** gap in knowledge hinders the development of targeted interventions and resource allocation *** The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two ***,females exhibited a remarkable decrease in mortality compared to ***,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward *** America and the Caribbean also experienced an increase in mortality ***,no significant difference was observed in the Middle East and North *** America exhibited a notable upward *** Asia and Sub-Saharan Africa significantly declined throughout the study *** raises the hope of identifying areas for implementing more targeted *** some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24].