Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

作     者：Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman Kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino Sanjaya K Satapathy 

作者机构：Department of Internal MedicineAllama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of GastroenterologyMather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and HepatologyEast Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal MedicineJefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal MedicineSt.Dominic's HospitalJacksonMS 39216United States Department of Internal MedicineSaint Francis Hospital and Medical CenterHartfordCT 06105United States Division of HepatologyGeisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal MedicineCampbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal MedicineNorth Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of HepatologyNorth Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States 

出 版 物：《World Journal of Transplantation》 (世界移植杂志)

年 卷 期：2024年第14卷第2期

页      面：62-75页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality 

摘      要：BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),P0.001].The frequency of transplant rejections among hospitalized LT recipients increased from 0.2%to 3.6% between January 2019 and December *** hospitalizations during the COVID-19 pandemic had a higher associ