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Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

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World Journal of Gastroenterology 2021年第9期27卷 794-814页

作者： sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito Karin N Westlund Research Service New Mexico Veterans Affairs Healthcare SystemAlbuquerqueNM 87108United States Department of Surgery University of KentuckyLexingtonKY 40536United States College of Liberal Arts University of TexasAustinTX 78712United States Department of Anesthesiology and Critical Care Medicine University of New Mexico Health Sciences CenterAlbuquerqueNM 87131United States

BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to *** validated caerulein-(CAE)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for *** To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in *** Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAE(50μg/kg),3 d a week for 6 wk in male C57BL/6J *** in week 4,mice received either vehicle or ALC until experiment’s *** hypersensitivity was assessed with von Frey *** hypersensitivity was determined with the hotplate ***-like behavior was tested in week 6 using elevated plus maze and open field *** activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).RESULTS Mice with CAE-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing *** with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections *** with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to *** with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not *** all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous *** mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast Green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAE-induced pancreatitis that was no

关键词： Acute recurrent pancreatitis Neuropathic pain Mechanical hypersensitivity Heat hypersensitivity Anxiety-like behavior Ionized calcium-binding adaptor molecule 1

Co-administration of cyclosporine A alleviates thioacetamide-induced liver injury

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World Journal of Gastroenterology 2005年第10期11卷 1411-1419页

作者： sabrina Fan Ching-Feng Weng Institute of Biotechnology

AIM: To investigate the effects of cyclosporine A (CsA)on thioacetamide (TAA)-induced liver ***: CsA was co-administrated (7.5 μg/kg body weight per day, i.p.) into rat to investigate the role of CsA on TAA-(200 mg/kg body weight per 3 d for 30 d, i.p.)induced liver ***: The data show that TAA caused liver fibrosis in rat after 30 d of treatment. CsA alleviates the morphological changes of TAA-induced fibrosis in rat liver. The blood glutamyl oxaloacetic transaminase (GOT)/glutamyl pyruvic transaminase (GPT) in the TAA-injury group is elevated compared to that of the normal rat. Compared with the TAA-injury group, the blood GOT/GPT and TGFβ1 (by RT-PCR analysis) are reduced in the CsA plus TAA-treated rat. The level of the transforming growth factor receptor I (TGFβ-R1) in the CsA plus TAA-treated group shows higher than that in the TAA only group, but shows a lower level of the fibroblast growth factor receptor 4 (FGFR4)in the CsA plus TAA-treated group, when using the Western blot analysis. After immunostaining of the frozen section,TGFβ-R1 and FGFR4 are more concentrated in rat liver after CsA plus TAA ***: This result suggests that CsA has an alleviated effect on TAA-induced liver injury by increasing the multidrug resistance P-glycoprotein and could be through the regulation of TGFβ-R1 and FGFR4.

关键词： Cyclosporine A Thioacetamide Liver injury P-glycoprotein TGFβ1 TGFβ-R1 FGFR4

The immunomodulating effect of bifidobacteria is modified by the anticoagulant acenocoumarol

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Food Bioscience 2023年第2期52卷 1166-1174页

作者： sabrina E.Assad Melisa Fragomeno Martin Rumbo Jessica Minnaard Pablo F.Perez Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos-UNLP-CONICET CCT La PlataArgentina Catedra de Microbiologia FCEUNLPCalle 47 y 116CP 1900La PlataBs.AsArgentina Instituto de Estudios Inmunologicos y Fisiopatologicos-UNLP-CONICET-CCT La PlataArgentina

Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host *** study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial *** bifidum CIDCA 5310 and *** CIDCA 5317 were grown in MRS broth in anaerobic *** experiments were done in the presence of ***-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,***,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow *** using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by *** decreased phagocytosis of bifidobacteria but intracellular routing was not ***,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 ***,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 *** increased CCL20 expression and it was partially abrogated by strain CIDCA *** of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.

关键词： Bifidobacterium Acenocoumarol THP-1 cells Caco-2 ccl20:luc reporter system Immune response Anticoagulant

Requirements Negotiation： Making System Stakeholders＇ Multiple-Views One

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通讯和计算机（中英文版） 2011年第4期8卷 290-299页

作者： sabrina Ahmad Faculty of Information and Communication Technology Universiti Teknikal Malaysia Melaka Melaka 76100 Malaysia

sabrina：行走神秘非洲，探寻公益的意义

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中学生博览 2024年第5期 10-15页

作者： sabrina 赵多

大咖会客厅问：看到您的教育背景里的专业是教育心理学，您当时为什么想学教育心理学？跟现在的工作是怎么结合的呢？答：我最初接触到心理学，是初中时候一堂有意思的心理沙盘课，根据自己的意愿和需要，选择和摆放各种小型模型，创造...

大咖会客厅问：看到您的教育背景里的专业是教育心理学，您当时为什么想学教育心理学？跟现在的工作是怎么结合的呢？答：我最初接触到心理学，是初中时候一堂有意思的心理沙盘课，根据自己的意愿和需要，选择和摆放各种小型模型，创造出独特的场景。通过这种与沙盘的互动，心理咨询老师进行分析，可以更深入地了解自己的内心世界和心理需求。

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Habitat and food preferences of European rabbits in core and edge populations along the invasion front PatagoniaMonte,Argentina

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Current Zoology 2024年第3期70卷 310-319页

作者： sabrina Yasmin Bobadilla María A.Dacar Fabián M.Jaksic Ricardo A.Ojeda María Fernanda Cuevas Ecología de Mamíferos de Tierras Secas IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Laboratorio de Filogeografía Taxonomía Integrativa y Ecología(LFTIE)IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Center of Applied Ecology and Sustainability(CAPES) Pontifcia Universidad Católica de ChileAv.Libertador Bernardo O'Higgins 340Santiago 8320000Región MetropolitanaChile

The European rabbit Oryctolagus cuniculus is an exotic herbivorous mammal undergoing an active phase of geographical expansion in the arid ecosystems of *** Adaptive Flexibility Hypothesis states that populations at the range edge(new populations)will exhibit greater fexibility in the use of resources compared with populations located in the range core(older populations).The objective of this work was to compare the rabbit’s use of spatial and trophic resources in relation to the establishment time of their *** sampling was carried out for 2 years(2017 and 2018)in sites with different establishment times for rabbit *** sampling stratifed by type of habitat was applied using 115 fxed strip transects of 1,000 m^(2) laid out across the study *** rabbit signs were recorded in each transect,and environmental and anthropic variables were *** results show that the individuals from the range edge are more selective in the use of habitat than those from the range *** the microhabitat level,we observed a pattern in the particular components of habitat use by rabbits mainly linked to food availability and proximity to *** a trophic perspective,rabbits could show fexible adjustment to novel conditions and environments in the range *** variability in resource use by the European rabbit confrms its ecological fexibility,pivotal for their advance toward new environments in Argentina.

关键词： Arid ecosystems invasive species novel environments range invasion spatial use trophic use

Sarcopenia and non-alcoholic fatty liver disease:Is there a relationship?A systematic review

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World Journal of Hepatology 2017年第6期9卷 326-332页

作者： Cristiane V Tovo sabrina A Fernandes Caroline Buss Angelo A de Mattos Postgraduate Program at Universidade Federal de Ciências da Saúde de Porto Alegre Clinical Medicine Department at Universidade Federal de Ciências da Saúde de Porto Alegre PostG raduate Program in Bioscience and Rehabilitation and the Post Graduate Program in Rehabilitation and Inclusion Methodist University-IPA Nutrition Department at Universidade Federal de Ciências da Saúde de Porto Alegre

AIM To perform a systematic review to evaluate the incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) in adult patients with *** Randomized clinical trials,cross-sectional or cohort studies including adult patients(over 18 years) with sarcopenia were *** primary outcomes of interest were the prevalence or incidence of NAFLD in sarcopenic *** the screening process,44 fulltext articles were included in the review and 41 studies were *** Three cross-sectional studies were *** authors attempted to perform a systematic review,but due to the differences between the studies,a qualitative synthesis was *** diagnosis of NAFLD was made by non-invasive methods(image methods or any surrogate markers) in all three evaluated *** the studies suggested that there was an independent association between sarcopenia and *** Sarcopenia is independently associated with NAFLD and possibly to an advanced fibrosis.

关键词： Metabolic syndrome Obesity morbid Sarcopenic obesity Steatohepatitis Skeletal muscle

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一种体育视频中广告牌商标的实时识别算法

自动化学报 2011年第4期37卷 418-426页

作者：卜江老松杨白亮 TOLLARI sabrina MARSALA Christophe 国防科学技术大学信息系统工程实验室巴黎第六大学LIP6实验室

近期,体育视频分析中的广告牌商标的探测和识别方法已经广泛应用于许多其他领域,比如商业电视.基于此,提出了一种能在不同体育视频(如足球、篮球和F1赛车等)中进行广告牌商标实时识别的算法,该算法主要包括两个步骤,首先,利用基于模糊... 详细信息

近期,体育视频分析中的广告牌商标的探测和识别方法已经广泛应用于许多其他领域,比如商业电视.基于此,提出了一种能在不同体育视频(如足球、篮球和F1赛车等)中进行广告牌商标实时识别的算法,该算法主要包括两个步骤,首先,利用基于模糊决策树的方法进行广告牌图像帧的探测;其次,利用颜色特征和局部SIFT(Scale-invariant feature transform)特征来描述不同商标的外观,并最终通过基于潜在语义分析(Latent semantic analysis,LSA)的SIFT词汇匹配来识别所给定的商标模板.初步的实验表明了本文算法的有效性,并且该算法能在实时情况下运行.

关键词：商标识别模糊决策树 SIFT词汇潜在语义分析

Representations of the Mediterranean and The Experiences of Migrant Women

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International Relations and Diplomacy 2014年第12期2卷 842-849页

作者： sabrina Garofalo University of Calabria Calabria Italy

This essay aims at creating a dialogue between the representations of the Mediterranean and the theories on the subject, as emerging from the interviews and life stories of women from the Maghreb and Romania. In particular, starting from the migrant women＇ voice, it is possible to elaborate on concepts such as： distance and proximity, dialectically connected and subjectively revised; marginality that is intended as a place of narrative and also like analytical category; hybridity in all aspects of political and subjective field; dual absence and double presence, in close connection in the daily experiences of these women. These concepts are part of a theoretical frame that takes into consideration the construction of othemess and recognition through the counter-narration of migration, and the idea of the Mediterranean as a migratory space. The narrative of the Mediterranean emerging from the stories of migrant women, deconstructs the imagery of the Mediterranean as a border, making it possible to identify in the joumey itself the meaning of home.

关键词： migration Mediterranean women narration