The immunomodulating effect of bifidobacteria is modified by the anticoagulant acenocoumarol
作者机构：Centro de Investigacion y Desarrollo en Criotecnologia de Alimentos-UNLP-CONICET CCTLa PlataArgentina Catedra de MicrobiologiaFCEUNLPCalle 47 y 116CP 1900La PlataBs.AsArgentina Instituto de Estudios Inmunologicos y Fisiopatologicos-UNLP-CONICET-CCTLa PlataArgentina
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2023年第52卷第2期
页 面：1166-1174页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Bago Laboratories National Academy of Medicine, NAM Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT Universidad Nacional de La Plata, UNLP
主 题：Bifidobacterium Acenocoumarol THP-1 cells Caco-2 ccl20:luc reporter system Immune response Anticoagulant
摘 要：Bifidobacteria are health promoting microorganisms that can interact with drugs in the intestinal tract thus modifying the activation of immune cells and host *** study the effect of acenocoumarol on the interaction between bifidobacteria and THP-1 cells or intestinal epithelial *** bifidum CIDCA 5310 and *** CIDCA 5317 were grown in MRS broth in anaerobic *** experiments were done in the presence of ***-labeled bacteria were incubated with THP1 cells differentiated with PMA(THP1-PMA),and phagocytosis and intracellular localization of bacteria were assessed by flow cytometry and confocal laser microscopy,***,expression of macrophage surface molecules in THP1 and THP1-PMA cells was assessed by flow *** using the Caco-2 ccl20:luc reporter system innate immune response was analysed by determining luciferase expression induced by *** decreased phagocytosis of bifidobacteria but intracellular routing was not ***,anticoagulant reduced the expression of HLA-DR and CD64 induced by bifidobacteria in both THP1-PMA and THP1 ***,the decrease in the expression of CD206 and CD23 was dependent on differentiation status of THP1 *** increased CCL20 expression and it was partially abrogated by strain CIDCA *** of acenocoumarol modifies the interaction between bifidobacteria and eukaryotic cells thus suggesting that the expected modulation of immune response by probiotic foods can be different in persons under anticoagulant treatment.
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