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Effects of electroacupuncture pretreatment on M1 polarization of alveolar macrophages in rats with acute lung injury

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Journal of Acupuncture and Tuina Science 2022年第1期20卷 22-31页

作者： ZHANG Yi su jingchao CHENG Chen WANG Caiyun MIAO Qing ZHANG Jingtao ZHANG Xinfang XIANG Shuiying LIU Zibing Graduate School Anhui University of Chinese MedicineHefei 230012China Jingxian County Hospital of Traditional Chinese Medicine Jingxian 242500China School of Integrated Traditional Chinese and Western Medicine Anhui University of Chinese MedicineHefei 230012China Institute of Acupuncture and Meridian College of Acupuncture-moxibustion and TuinaAnhui University of Chinese MedicineHefei 230012China

Objective:To observe the effects of electroacupuncture(EA)pretreatment on M1 polarization of alveolar macrophages(AMs)in rats with acute lung injury(ALI)induced by lipopolysaccharide(LPS),and to explore the potential protective mechanism of ***:Forty Sprague-Dawley rats were randomly divided into a normal group,a model group,and three groups of EA pretreatment[including a Chize(LU5)group,a Zusanli(ST36)group and a Chize(LU5)plus Zusanli(ST36)group],with eight rats in each *** model rats of ALI were established by instilling LPS[2 mg/(kg·bw)]into the trachea of rats for 3 *** rats in each EA pretreatment group were pretreated with EA for 30 min per day at the corresponding bilateral acupoints 6 d before instilling *** hours after modeling,the pulmonary function of the rats was tested,and the lung tissue was taken to calculate the ratio of lung wet weight to dry weight(W/D).The pathological lung changes and the injury score were observed by hematoxylin-eosin *** contents of tumor necrosis factor(TNF)-α,interleukin(IL)-1β,and myeloperoxidase(MPO)in rat's bronchoalveolar lavage fluid(BALF)were detected by enzyme-linked immunosorbent *** mRNA and protein expression levels of M1 macrophage markers clusters of differentiation 86(CD86),inducible nitric oxide synthase(iNOS),and its signaling pathway factor Toll-like receptor(TLR)4,and nuclear factor-κB(NF-κB)p65 in the alveoli were detected by fluorescence quantitative polymerase chain reaction and Western blot,***:After being induced by LPS,the pulmonary function of the model rats showed that the forced expiratory volume in 0.1 s(FEV0.1),forced expiratory volume in 0.3 s(FEV0.3),and their respective ratios of FEV to forced vital capacity(FVC)(including FEV0.1/FVC and FEV0.3/FVC)were significantly decreased(Psue was increased(P<0.01).The score of lung injury was significantly higher(P<0.01).The contents of TNF-α,IL-1β,and MPO in the BALF and

关键词： Acupuncture Therapy Electroacupuncture Acute Lung Injury Macrophages Alveolar Tumor Necrosis Factor-alpha NF-kappa B Signal Transduction Rats

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航空发动机叶片表面热障涂层温度分布的仿真分析

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上海交通大学学报 2017年第8期51卷 915-920页

作者：段力高均超汪瑞军胡铭楷苏靖超成清清张博袁涛上海交通大学电子信息与电气工程学院上海200240 北京金轮坤天特种机械有限公司北京100083 上海交通大学工科试验班上海200240

采用有限元固体热传导仿真模型分析航空发动机导向叶片表面热障涂层(TBC)的温度特性;采用工程实验的通用模型,输入因变量(Input)→仿真模型和边界条件(Process)→输出变量(Output),进行热障涂层的实验设计;比较了几种热涂层材料(如ZrO2... 详细信息

采用有限元固体热传导仿真模型分析航空发动机导向叶片表面热障涂层(TBC)的温度特性;采用工程实验的通用模型,输入因变量(Input)→仿真模型和边界条件(Process)→输出变量(Output),进行热障涂层的实验设计;比较了几种热涂层材料(如ZrO2系列TBC)的隔热性能,分析了不同的基底与TBC厚度下隔热性能的变化情况.同时,通过计算机仿真方法探讨了国内外相关文献中的TBC隔热效果的差异性.结果表明,温度边界条件对于准确估算TBC的隔热效果至关重要.在对比TBC的隔热性能时,需对测温环境进行标定.

关键词：航空发动机热障涂层有限元法

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电针调控PI3K/AKT/mTOR通路改善血管性痴呆大鼠海马神经元炎性和氧化损伤机制

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上海针灸杂志 2024年第3期43卷 326-334页

作者：毕珂瑶李赫妍苏景超陶树琴唐巍安徽中医药大学合肥230038 安徽中医药大学针灸经络研究所合肥230012

目的探讨电针百会、足三里穴调控磷脂酰肌醇3激酶(phosphatidylinositol 3 kinase, PI3K)/蛋白激酶B(protein kinase B, AKT)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin, mTOR)通路改善血管性痴呆(vascular dementia, VD)大鼠海马组织神经元炎性和氧化损伤机制。方法 45只雄性SD大鼠,随机分为假手术组、模型组和电针组,每组15只。模型组与电针组大鼠采用双侧颈动脉结扎法(2-VO)制备VD模型,假手术组颈动脉分离不结扎。电针组造模3 d后电针百会、足三里穴,每日1次,连续2周,第7天和第14天间断治疗。Morris水迷宫实验检测各组大鼠空间记忆和学习能力。Nissl染色法观察海马区神经元结构形态;酶联免疫吸附测定法检测血清白介素-1β(interleukin-1β, IL-1β)、IL-6(interleukin 6, IL-6)以及谷胱甘肽过氧化物酶(glutathione peroxidase, GSH-Px)含量;生化检测海马组织丙二醛(malonaldehyde, MDA)和超氧化物歧化酶(superoxide dismutase, SOD)含量;Western blot法检测海马组织中p-PI3K、p-Akt及p-mTOR蛋白表达量;免疫组化法观察海马组织mTOR蛋白阳性表达。结果与假手术组比较,模型组大鼠空间记忆和学习能力明显下降(P<0.01),Nissl染色显示神经元受损明显,MDA、IL-1β和IL-6含量显著升高(P<0.01),GSH-Px含量、SOD含量、p-PI3K、p-Akt及p-mTOR蛋白表达显著降低(P<0.01),mTOR阳性表达量降低(P<0.01)。与模型组比较,电针组大鼠空间记忆和学习能力显著提升(P<0.01),Nissl染色显示神经元形态显著改善,MDA、IL-1β和IL-6含量显著降低(P<0.01),GSH-Px含量、SOD含量、p-PI3K、p-Akt及p-mTOR蛋白表达水平显著升高(P<0.01), mTOR阳性表达量明显升高(P<0.01)。结论电针可能通过上调PI3K/AKT/mTOR信号通路来降低炎症反应与氧化损伤,从而保护VD大鼠海马神经元,并改善其认知能力。

关键词：电针血管性痴呆炎症反应氧化损伤 PI3K/AKT/mTOR通路大鼠

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急性肺损伤大鼠模型制备及不同时段肺损伤比较

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中国实验动物学报 2021年第1期29卷 27-34页

作者：张毅程晨苏景超张新芳刘心月项水英王彩云李尹林先刚刘自兵安徽中医药大学研究生院合肥230038 安徽中医药大学中西医结合学院合肥230038 安徽中医药大学针灸推拿学院针灸经络研究所合肥230038 针灸基础与技术安徽省重点实验室合肥230038

目的通过气管滴注脂多糖(lipopolysaccharide,LPS)构建急性肺损伤大鼠模型,观察不同时段肺损伤变化规律。方法32只健康SD大鼠随机分为正常组、模型组,正常组8只大鼠,模型组24只大鼠。模型组依据LPS滴注时长不同分为三个亚组:3 h组、6 h... 详细信息

目的通过气管滴注脂多糖(lipopolysaccharide,LPS)构建急性肺损伤大鼠模型,观察不同时段肺损伤变化规律。方法32只健康SD大鼠随机分为正常组、模型组,正常组8只大鼠,模型组24只大鼠。模型组依据LPS滴注时长不同分为三个亚组:3 h组、6 h组和12 h组,每组8只。以LPS(2 mg/kg)暴露式气管滴注法复制ALI大鼠模型。通过大鼠一般状况、肺大体观察、肺功能检测、计算肺湿干重比值、支气管肺泡灌洗液(BALF)中白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)检测和肺组织中丙二醛(MDA)、超氧化物歧化酶(SOD)检测、苏木素-伊红染色(HE染色)组织形态学观察,评估不同时段急性肺损伤伤情变化情况。结果造模后模型组大鼠存活率为100%。大鼠一般状况显示,3 h组与正常组相比,精神处于淡漠状态、摄食减少、活动明显减少、鼻腔处粘液分泌物增多、大鼠的呼吸频率加快、可闻及哮鸣音。肺大体观察显示,3 h组左右肺门处可见肺组织肝样变,左右肺叶上散布出血点,出血部位颜色鲜红。肺功能显示3 h组大鼠第0.1秒用力呼气量(FEV0.1)、第0.3秒用力呼气量(FEV 0.3)以及各占用力肺活量(FVC)之比(FEV0.1/FVC;FEV0.3/FVC)均显著下降(P<0.05,P<0.01);肺湿干重比值明显升高(P<0.01);BALF中IL-1β、IL-8、TNF-α含量明显升高(P<0.01),MDA含量显著升高(P<0.01),SOD含量显著降低(P<0.01);HE染色可见明显肺泡间隔增厚、肺间质水肿、红细胞渗出。结论暴露式气管滴注LPS法,可以引起大鼠肺功能显著下降、剧烈的肺部炎症、氧化-抗氧化失衡及严重肺水肿和肺出血,导致急性肺损伤,在3 h时段更有利于ALI大鼠模型的构建。

关键词：急性肺损伤模型气管滴注法脂多糖

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Method for Latency Measurement of Visual Feedback-Based Master–Slave Minimally Invasive surgical Robot

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Transactions of Tianjin University 2018年第4期24卷 375-386页

作者： Jinhua Li jingchao Shen He su Shuxin Wang Jianmin Li School of Mechanical Engineering Tianjin UniversityTianjin 300350China College of Computer and Control Engineering Nankai UniversityTianjin 300350China Key Laboratory for Mechanism Theory and Equipment Design of Ministry of

To measure the latency between human motion stimulation and stereo image display response in a visual feedback-based minimally invasive surgical(MIS) robotic system,a method was proposed by comparing the orientations of input and output events through image-processing technology. This method used a black bar to keep pace with the measured joint rotating at a number of speeds. During tests,an external camera was placed in front of the apparatus with a proper visual field,so that it can simultaneously view orientations of both bars fixed on the corresponding joints. After quantitatively analyzing the accuracy of the proposed measurement method,the method was applied to a visual feedback-based master–slave robotic system with two-degrees-of-freedom. Experimental results show that the latency of the overall system was approximately 250 ms,and the opposite clearance of the measured joint was in the range of 1.7°–1.9°.

关键词： Minimally invasive surgical(MIS)robot Latency measurement Real time Visual feedback

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Transmission of climate change impacts from temperature change to grain harvests, famines and peasant uprisings in the historical China

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Science China Earth Sciences 2015年第6期58卷 1427-1439页

作者： FANG XiuQi su Yun YIN Jun TENG jingchao School of Geography Beijing Normal University

Because of the complexity of social responses to climate change,as well as limitations of proxy data concerning interactions between climate change and human responses,the social impacts of past climate change and associated response mechanisms,thus,require further *** shed light on the transmission of climate change impacts within historical Chinese society,we selected 30-year resolution sequences of temperature anomalies in eastern China and 10-year resolution sequences of grain harvest grades,famine indices,and frequencies of peasant uprisings in China over the past 2000 *** a food security perspective,we analyzed the impacts of temperature changes historically transmitted through Chinese production,population,and social subsystems,and differences in transmission characteristics between cold and warm *** results were as follows.(1)From 210 BC to 1910 AD,temperature changes in China were significantly positively correlated with grain harvest grades(correlation coefficient,0.338),and significantly negatively correlated with famine indices,and frequencies of peasant uprisings(correlation coefficients,-0.301 and-0.277,respectively).The correlation coefficients between famine indices and grain harvest grades or frequencies of peasant uprisings were very low.(2)There was a higher proportion of bumper or normal harvests(86.5%of the total decades),more moderate and mild famines(76%),and a lower proportion of peasant uprisings(33.3%)in the 30-year warm ***,there was a higher proportion of poor or normal harvests(70.7%),a greater proportion of moderate and severe famines(77.6%),and more peasant uprisings(51.7%)in the 30-year cold units.(3)Of the 23 main transmission pathways extending from temperature change to the social subsystem,13 occurred in cold units,of which 7 had an endpoint of peasant uprisings,and 10 occurred in warm units of which 3 had an endpoint of peasant *** main transmission pathways that were more likely

关键词： chain of climate change impacts grain harvests famines peasant uprisings historical Chinese society

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Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

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Nano Research 2020年第1期13卷 173-182页

作者： Zhide Guo Liu Yang Mei Chen Xuejun Wen Huanhuan Liu jingchao Li Duo Xu Yuanyuan An Changrong Shi Jindian Li Xinhui su Zijing Li Ting Liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102China State Key Laboratory for Bioactive substances and Functions of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China College of Materials Science and Engineering Hunan UniversityChangsha410082China The State Key Laboratory for Physical Chemistry of Solid surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryXiamen UniversityXiamen361005China Zhongshan Hospital Affiliated to Xiamen University Xiamen361004China

Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable *** objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic *** and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic *** signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@*** studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque *** characterization revealed that the signal of probe was in accordance with the high-risk *** summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques.

关键词： 2D material folate receptor multifunctional imaging activated macrophages atherosclerosis

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Numerical Model and Simulation Analysis of Composite Stringer Docking Structures

Numerical Model and Simulation Analysis of Composite Stringe...

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作者： jingchao Wei Gang Wang su Cao Xiangming Chen Aeronautics Science and Technology Key Laboratory of Full Scale Aircraft Structure and Fatigue Aircraft Strength Research Institute of China

Due to the manufacturing restrictions or design requirements, composite structures are usually connected in the form of butt joint near the wing rib or fuselage frame to solve the problem of discontinuity of load transfer. In this paper, the finite element model of butt joint structure is established by simulating the engineering model of metal fasteners and common joint connected by beam element under the action of in-plane load, and the mechanical simulation analysis of typical butt joint configuration is carried out. In the engineering model, the allowable stress value is used to predict the failure of composite material and the classical strength theory is used to predict the fracture failure of metal fasteners. The result show that the strength prediction obtained by the engineering model is in good agreement with the test results, and the application of this method can improve the calculation efficiency of connection strength with complicated multi-fastened composite structures.

关键词： numerical model simulation analysis strength prediction composite structure

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Animal models of T-cell acute lymphoblastic leukemia: mimicking the human disease

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Journal of Bio-X Research 2018年第1期1卷 32-40页

作者： Qin You Hexiu su jingchao Wang Jue Jiang Guoliang Qing Hudan Liu Medical Research Institute Wuhan University Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

T-cell acute lymphoblastic leukemia(T-ALL)is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic *** the past decade,large-scale genomic analysis has shed new light on providing potentially important oncogenic or tumor suppressive candidates involved in the disease *** in silico analysis,functional studies are usually performed to vigorously investigate the biological roles of candidate *** this purpose,animal models faithfully recapitulating the human disease are widely applied to decipher the mechanism underlying T-cell ***,an increased understanding of T-ALL biology,including identification of oncogene NOTCH1,TAL1 and MYC as well as tumor suppressor phosphatase and tensin homolog(PTEN),has significantly improved the development of T-ALL animal *** progresses have opened opportunities for development of new therapeutic strategy to benefit T-ALL *** this review,we particularly summarize the mouse and zebrafish models used in T-ALL research and also the most recent advances from these in vivo studies.

关键词： hematopoietic stem cell transplant T-cell acute lymphoblastic leukemia transgenetic mice transgenic zebrafish xenograft

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经典风险模型中破产变量的联合分布

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深圳大学学报（理工版） 2019年第4期36卷 419-423页

作者：苏必豪李婧超深圳大学数学与统计学院

破产理论对风险衡量和风险调控至关重要,破产索赔作为破产理论的一大重点问题,通过研究总索赔额随时间的分布,可以对风险进行较好描述,根据其分布的特征,可采取注资及保费再调整等方式进行风险调控.在经典风险模型中,优先考虑的4个破产... 详细信息

破产理论对风险衡量和风险调控至关重要,破产索赔作为破产理论的一大重点问题,通过研究总索赔额随时间的分布,可以对风险进行较好描述,根据其分布的特征,可采取注资及保费再调整等方式进行风险调控.在经典风险模型中,优先考虑的4个破产相关变量为:破产时间、截止至破产时的总索赔额、截止至破产时的总索赔次数及破产时的赤字.本研究考虑截止至破产时的总索赔额与其他破产变量的联合概率密度函数,给出当个体索赔为指数分布时,不同联合概率密度函数的表达式.指出当个体索赔分布服从某一类特定分解形式时,联合概率密度函数的表达式也可以分解并求出。

关键词：概率论经典风险模型破产时间破产时赤字破产时的总索赔额破产时的总索赔次数联合概率密度函数

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