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Expression of PC-cell-derived growth factor in breast cancer

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Frontiers of Medicine 2009年第4期3卷 426-430页

作者： haiping song Lan SHI Chunping LIU Tao HUANG Thyroid and Breast Surgical Center Union HospitalHuazhong University of Science and TechnologyWuhan 430022China

This study is mainly aimed at evaluating the expression of PC-cell-derived growth factor(PCDGF)in breast cancer and breast adenoﬁbroma,and to compare with other commonly used clinical pathological indices,then to investigate the diagnostic and targeted therapeutic purpose of PCDGF in breast cancer *** this study,we detected the expression of PCDGF,p53 and CerbB-2 in breast cancer tissue and the expression of PCDGF in breast adenoﬁbroma tissue by immunohistochemical method,and analyzed the relationship between *** found that PCDGF was expressed in most breast cancer tissue,but was not in breast adenoﬁbroma tissue,and the expression of PCDGF was related with the tumor’s pathological category and the expression of estrogen receptor(ER)and progesterone receptor(PR)and p53,but there was no statistical dependability between PCDGF and *** this study,we predict that PCDGF may serve as a marker in the secondary diagnosis of breast cancer,and may participate in the generation and differentiation of breast cancer cells,and become an effective target of therapy for breast cancer.

关键词： PC-cell-derived growth factor breast neo-plasms clinical markers

早期宫颈癌患者血清HMGB1、TLR4和RAGE4水平对肿瘤恶性生物学行为的指向性研究

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河北医药 2024年第4期46卷 506-510,515页

作者：杨红玉郭婧宋海萍董俊婵王恺孙亚楠中国人民解放军联勤保障部队第九八〇医院(白求恩国际和平医院)妇产科石家庄市050000 中国人民解放军联勤保障部队第九八〇医院(白求恩国际和平医院)第五派驻门诊部石家庄市050000

目的分析早期宫颈癌血清HMGB1、TLR4和RAGE4水平对肿瘤恶性生物学行为的指向性评估价值。方法选取2016年3至2019年6月确诊的早期宫颈癌患者139例,对患者进行病理诊断并分期,取患者研究期1周内晨起空腹静肘脉血,以酶联免疫吸附的方式检... 详细信息

目的分析早期宫颈癌血清HMGB1、TLR4和RAGE4水平对肿瘤恶性生物学行为的指向性评估价值。方法选取2016年3至2019年6月确诊的早期宫颈癌患者139例,对患者进行病理诊断并分期,取患者研究期1周内晨起空腹静肘脉血,以酶联免疫吸附的方式检测患者血清肿瘤局部免疫状态炎性因子(HMGB1、TLR4和RAGE4)和肿瘤恶性生物学行为调控因子(Caspase-3、bcl-2、MMP-1)水平。评估血清HMGB1、TLR4和RAGE4水平对早期宫颈癌分期的预评估效能。进一步分析HMGB1、TLR4和RAGE4与Caspase-3、bcl-2、MMP-1指标间的量化相关性。结果分期组间各因子水平比较结果显示,Ⅰa期与Ⅰb期、Ⅰa期与Ⅱa期患者血清肿瘤局部免疫状态炎性因子(HMGB1、TLR4和RAGE4)和肿瘤恶性生物学行为调控因子(Caspase-3、bcl-2、MMP-1)水平差异均有统计学意义(P<0.05);ROC曲线分析结果提示,HMGB1对早期宫颈癌Ⅰa期与Ⅰb期具有较高的预测鉴别诊断价值,曲线下面积为0.939,诊断临界值为0.83 ng/mL(灵敏度为97.62%,特异度为86.60%)。血清肿瘤局部免疫状态炎性因子与肿瘤恶性生物学行为调控因子水平相关分析结果显示,各因子水平均呈现高度正相关,相关系数0.715~0.854。结论早期宫颈癌患者血清局部免疫状态炎性反应因子对肿瘤恶性生物学行为具有一定的定性与定量指向性预测诊断价值,与恶性生物学行为相关因子水平高度相关。

关键词：早期宫颈癌炎性因子恶性生物学行为指向性

Language Learner Motivation Related Theoretical Framework

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International English Education Research 2016年第1期 80-81页

作者： song haiping Foreign Language School Southwest University of Political Science and Law Chongqing 401120

Interest in studying individual differences （IDs） is driven by a trend characteristic of educational psychology in general and of second language acquisition （SLA） research in particular. Language learning motivation and self-determination theory （SDT） and an SDT-sub theory framework termed cognitive evaluation theory （CET） are reviewed in this article.

关键词： individual differences (IDs): second language acquisition (SLA): self-determination theory (SDT) cognitive evaluationtheory (CET)

Anxiety and Motivation in Foreign Language Achievement

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International English Education Research 2016年第1期 71-72页

作者： song haiping Foreign Language School Southwest University of Political Science and Law Chongqing 401120

Language anxiety and language motivation have been studied extensively by experts in foreign language （FL） learning. Both of these constructs have been found to be closely correlated to FL achievement. In this article, the author has reviewed foreign language anxiety, language motivation and the relationship between language motivation and language anxiety.

关键词： language anxiety language motivation FL achievement

C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data

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Cancer Communications 2023年第3期43卷 400-404页

作者： haiping song Hector Manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He Eleanor Lawrence Alison Gartland Jian Luo Ning Wang Department of Internal Medicine-Oncology Qingdao Tumor HospitalThe Second Affiliated Hospital of Medical College of Qingdao UniversityQingdaoShandong 266042P.R.China The Mellanby Centre for Musculoskeletal Research Department of Oncology and MetabolismThe University of SheffieldSheffieldSouth Yorkshire S102RXUK Yangzhi Rehabilitation Hospital(Sunshine Rehabilitation Centre) Tongji University School of MedicineShanghai 201619P.R.China

Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa *** adenosine triphosphate(ATP)was shown to be a major biochemical constituent of the tumor microenvironment and regulates the tumor and host interactions by acting at P2 purinergic *** the P2 receptors,the ion channel P2X purinergic receptor 7(P2X7R)has an unusually long C-terminus containing 200 amino acids,which forms the molecular basis for the unique bi-function of P2X7R promoting cancer cell proliferation or inducing membrane permeabilization and apoptosis,upon activation by a low or high concentration of ATP,respectively.

关键词： metastasis cancer clinical

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H:quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第1期22卷 75-88页

作者： song Jiangzhou ZOU Guiqing ZHAO Zhou ZHU Ya XUE Jiayu AO Lanjia SUN Huiyong HAO haiping ZHANG Bo XU Xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer ***1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ROS)*** ROS generation results in extensive DNA damage and elevated poly(ADP-ribose)polymerase 1(PARP1)-mediated consumption of nicotinamide adenine dinucleotide(NAD^(+)),ultimately causing cell *** phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD^(+)salvage synthesis pathway,emerges as a critical target in cancer *** concurrent inhibition of NQO1 and NAMPT triggers hyperactivation of PARP1 and intensive NAD+*** this study,we designed,synthesized,and assessed a novel series of proqodine A derivatives targeting both NQO1 and *** these,compound T8 demonstrated potent antitumor ***,T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and *** discovery offers a promising new molecular entity for advancing anticancer research.

关键词： NQO1 ROS NAMPT NAD^(+) T8

4×4 MIMO fiber-wireless transmission based on an integrated four-channel directly modulated optical transceiver

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Photonics Research 2019年第12期7卷 1461-1467页

作者： DI ZHANG YAO YE LEI DENG DI LI haiping song YUCHENG ZHANG MINMING ZHANG SHU WANG DEMING LIU School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

In this paper, an integrated compact four-channel directly modulated analog optical transceiver is proposed and fabricated. The 3 d B bandwidth of this optical transceiver exceeds 20 GHz, and the measured spurious-free dynamic range is up to 91.2 d B · Hz^2∕3. The optical coupling efficiency(CE) is improved by using a precise submicron alignment technique for lens coupling in a transmitter optical subassembly, and the highest CE is achieved when the oblique angle of the arrayed waveguide grating using a silica-based planar lightwave circuit(AWG-PLC) in receiver optical sub assembly is set to 42°. Based on the proposed optical transceiver, we have experimentally demonstrated a 6.624 Gbit/s 4 × 4 multi-input multioutput(MIMO) 16-quadrature amplitude modulation orthogonal frequency division multiplexing(16 QAM-OFDM) radio signal over 15.5 km standard single mode fiber, together with 1.2 m wireless transmission in both an uplink and a downlink. To cope with the channel interference and noise of the fiber-wireless transmission system, a low-complexity MIMO demodulation algorithm based on lattice reduction zero-forcing(LR-ZF) is designed. In our experiment, 1.6 d B power penalty is achieved by using the proposed LR-ZF algorithm, compared to the commonly used zero-forcing ***, this LR-ZF algorithm has much less complexity than the optimal maximum-likelihood sequence estimation(MLSE) at a given transmission performance. These results not only demonstrate the feasibility of the integrated optical transceiver for MIMO fiber-wireless application but also validate that the proposed LR-ZF algorithm is effective to eliminate the interference for hybrid fiber-wireless transmission.

关键词： fiber MIMO transceiver

Application of Active Disturbance Rejection Control in Tank Gun Control System

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Application of Active Disturbance Rejection Control in Tank ...

第40届中国控制会议

作者： Wenjun Zhao Yuanqing Xia haiping song Zhongqi Sun Yifeng Xu School of Mechatronical Engineering Beijing Institute of Technology School of Automation Beijing Institute of Technology North Vehicle Research Institute

This paper develops an active disturbance rejection control（ADRC） scheme for tank gun control servo systems, aiming at achieving a high tracking precision and suppressing the influence of uncertainties on the controlled object. On the basis of tank gun system modeling, ADRC is designed for both the velocity and position tracking control loop. The unknown parameters are estimated according to bandwidth method and the performance of the ADRC is verified by numerical simulations. The results show that ADRC not only performs better than classical PID in solving tracking accuracy, but also has a good performance in anti-interference.

关键词： ADRC Tank Gun Control System Velocity and Position Tracking Anti-interference

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特征向量灵敏度分析的快速级数展开法

东南大学学报（自然科学版） 2000年第3期30卷 88-91页

作者：宋海平周传荣南京航空航天大学南京210016

根据特征向量灵敏度分析的模态法 ,研究出计算特征向量灵敏度的快速级数展开法 .该方法是用Neumann矩阵级数的形式来等效未知模态对特征向量灵敏度的贡献 ,并引入特征值移位量来控制矩阵级数的收敛性 ,从而明显地提高了计算效率 .算例... 详细信息

根据特征向量灵敏度分析的模态法 ,研究出计算特征向量灵敏度的快速级数展开法 .该方法是用Neumann矩阵级数的形式来等效未知模态对特征向量灵敏度的贡献 ,并引入特征值移位量来控制矩阵级数的收敛性 ,从而明显地提高了计算效率 .算例表明本文方法对已知少数前几阶模态的复杂结构 ,仅取级数的前

关键词：特征向量灵敏度 Neumann级数