C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data

作     者：Haiping Song Hector Manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He Eleanor Lawrence Alison Gartland Jian Luo Ning Wang 

作者机构：Department of Internal Medicine-OncologyQingdao Tumor HospitalThe Second Affiliated Hospital of Medical College of Qingdao UniversityQingdaoShandong 266042P.R.China The Mellanby Centre for Musculoskeletal ResearchDepartment of Oncology and MetabolismThe University of SheffieldSheffieldSouth Yorkshire S102RXUK Yangzhi Rehabilitation Hospital(Sunshine Rehabilitation Centre)Tongji University School of MedicineShanghai 201619P.R.China 

出 版 物：《Cancer Communications》 (癌症通讯（英文）)

年 卷 期：2023年第43卷第3期

页      面：400-404页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Royal Society, UK [IEC\NSFC\170113] National Natural Science Foundation of China (NSFC) Qingdao Science and Technology Bureau Research Fund, China [18-6-1-98-nsh] 

主　　题：metastasis cancer clinical 

摘      要：Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa *** adenosine triphosphate(ATP)was shown to be a major biochemical constituent of the tumor microenvironment and regulates the tumor and host interactions by acting at P2 purinergic *** the P2 receptors,the ion channel P2X purinergic receptor 7(P2X7R)has an unusually long C-terminus containing 200 amino acids,which forms the molecular basis for the unique bi-function of P2X7R promoting cancer cell proliferation or inducing membrane permeabilization and apoptosis,upon activation by a low or high concentration of ATP,respectively.