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Updated prevalence of latent prostate cancer in Chinese population and comparison of biopsy results: An autopsy-based study

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The Innovation 2024年第1期5卷 80-87页

作者： Yuliang Chen Zhien Zhou Yi Zhou Zhipeng Mai Shijie Jin Zhen Liang zhiyuan shang Yuzhi Zuo Yu Xiao Wenze Wang Haibo Wang Weigang Yan Department of Urology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Gynaecology and Obstetrics Beijing HospitalNational Centre of GerontologyBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Peking University Clinical Research Institute Peking University First HospitalBeijing 100034China

Prostate cancer detected by autopsy is named latent prostate *** the repertoire of clinical prostate cancer,latent cancer may better reflect the disease *** clinical prostate specimens,which are obtained exclusively from biopsy-positive cases,prostate specimens obtained through autopsy provide information on biopsy-negative cases,helping calculate the true sensitivity of prostate *** 2014 to 2021,we collected autopsy specimens of the prostate from body donors in China and performed transperineal and transrectal biopsies on specimens before step-sectioning and pathological *** found that the crude prevalence of latent prostate cancer in middle-aged and elderly men was 35.1%(81/231),which was higher than previous estimates for Chinese *** overall per-patient sensitivities of transperineal and transrectal biopsies were not significantly different(33.3%vs.32.1%,p=0.82),but the two approaches differed in preferential sampling area along the proximal-distal axis of the *** biopsy had a higher sensitivity for detecting clinically significant lesions in the distal third(34.7%vs.16.3%,p=0.02)and distal half(30.6%vs.18.1%,p=0.04),while transrectal biopsy had a higher sensitivity for lesions in the proximal half(25.0%vs.13.9%,p=0.046).Both transperineal and transrectal methods of biopsy missed most small lesions(0.5 mL).In conclusion,the prevalence of latent prostate cancer in China has increased over the past 2 *** transperineal and transrectal methods of biopsy had comparable sensitivities but had different preferential sampling *** approaches miss one-third of large lesions.

关键词： biopsy prevalence latent

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Impacts of Total Energy Consumption Control and Energy Quota Allocation on China′s Regional Economy Based on A 30-region Computable General Equilibrium Analysis

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Chinese Geographical Science 2015年第6期25卷 657-671页

作者： LI Na SHI Minjun shang zhiyuan YUAN Yongna University of Chinese Academy of Sciences Research Center on Fictitious Economy & Data Science Chinese Academy of Sciences

This paper examined the impacts of the total energy consumption control policy and energy quota allocation plans on China′s regional economy. This research analyzed the influences of different energy quota allocation plans with various weights of equity and efficiency, using a dynamic computable general equilibrium(CGE) model for 30 province-level administrative regions. The results show that the efficiency-first allocation plan costs the least but widens regional income gap, whereas the outcomes of equity-first allocation plan and intensity target-based allocation plan are similar and are both opposite to the efficiency-first allocation plan′ outcome. The plan featuring a balance between efficiency and equity is more feasible, which can bring regional economic losses evenly and prevent massive interregional migration of energy-related industries. Furthermore, the effects of possible induced energy technology improvements in different energy quota allocation plans were studied. Induced energy technology improvements can add more feasibility to all allocation plans under the total energy consumption control policy. In the long term, if the policy of the total energy consumption control continues and more market-based tools are implemented to allocate energy quotas, the positive consequences of induced energy technology improvements will become much more obvious.

关键词： total energy consumption control energy quota allocation computable general equilibrium (CGE) model induced energytechnology improvements

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The vegetation feature and palaeoenvironment significance in the mountainous interior of southern China from the Last Glacial Maximum

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Science China Earth Sciences 2018年第1期61卷 71-81页

作者： XIAO JiaYi shang zhiyuan SHU Qiang YIN JianJi WU XiaoShuang Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing Normal University School of Geographical Sciences Nanjing Normal University

Palynological records were selected from the profiles of three research sites in the mountainous interior of southern China(Dajiuhu at Shennongjia in the western part of Hubei Province, Dahu in the Nanling Mountains, and Gantang in the northern part of Fujian Province). It can be inferred that the forest vegetation growing in the south of the Qinling Mountains-Huaihe River was luxuriant during the late glaciation. The species succession with ecological significance in palaeoflora(Abies sp., Fagus sp. and Alnus sp.) revealed that there was a certain amount of precipitation and effective humidity in the mountain lands between Qinling Mountains-Huaihe River and Nanling Mountains. This ecological environment favored the zonal distribution of mountainous forest vegetation. The late glacial maximum featured a cold, wet climate that completely differed from the cold-dry climate on the Loess Plateau, and on the steppe and desert steppe of the Qinghai-Tibet Plateau. Besides being influenced by the predominant factors driving the Northern Hemisphere climate, the cold-wet climate feature of the mountainous interior of southern China was closely associated with some geographical factors such as the latitudinal position, proximity to the ocean, and the topography and landforms.

关键词： Southern China Mountainous vegetation Last Glacial Period Pollen record Palaeoenvironment

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Evidence of Glacial Erratic Rollover Revealed by ^(10)Be and ^(26)Al Concentration Variations

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Acta Geologica Sinica(English Edition) 2022年第1期96卷 369-375页

作者： ZHANG Zhigang WANG Jian XU Xiaobin CHANG Zhiyang CUI Haitao LIANG Zhong CHEN Xia shang zhiyuan School of Geography Nanjing Normal UniversityNanjing 210023China Key Laboratory of Virtual Geographic Environment(Nanjing Normal University) Ministry of EducationNanjing 210023China State Key Laboratory Cultivation Base of Geographical Environment Evolution(Jiangsu Province) Nanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Jiangsu Second Normal University Nanjing 210013China Tourism and Social Administration College Nanjing Xiaozhuang UniversityNangjing 211171China

Cosmogenic nuclide exposure dating is one of the most intensively applied dating methods with which to study glacial *** erratics have been the major dating objective in many *** research has proposed that glacial erratics may undergo rollover and re-transportation during the late exposure stage,which can affect the dating ***,there is no direct evidence to confirm this *** this study,we collected seven samples from a vertical section inside a glacial erratic in the paleo-Daocheng ice cap in the southeastern Tibetan Plateau,measuring their contents of the cosmogenic nuclides ^(10)Be and ^(26)*** results show that from the top to the bottom,the concentrations of 10Be were(1.21±0.05)×10^(6),(1.00±0.02)×10^(6),(0.88±0.03)×10^(6),(0.77±0.02)×10^(6),(0.75±0.03)×10^(6),(0.95±0.03)×10^(6) and(1.46±0.04)×10^(6) atoms/*** ^(10)Be concentrations decreased from(1.21±0.05)×10^(6) atoms/g to(0.75±0.03)×10^(6) atoms/g and then increased to(1.46±0.04)×10^(6) atoms/g,which is not consistent with the theoretical prediction of a gradual *** phenomenon indicates that the glacial erratic may have rolled over at least *** lower surface of the erratic could have been on top at some time in the ***,its exposure age was greater than the exposure age that was expected,based on its current *** study provides numerical evidence for an erratic rollover event.

关键词： glacial erratics ^(10)Be and^(26)Al rollover Tibetan Plateau

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储粮害虫声检测技术研究进展与展望

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农业工程学报 2006年第4期22卷 204-207页

作者：耿森林尚志远陕西师范大学应用声学研究所

与传统的储粮害虫检测方法相比较,储粮害虫声检测技术以其简单、快速、价廉、准确等优点正日益受到重视。在综合分析国内外储粮害虫声检测技术研究的文献以及已有工作基础上,扼要评述了储粮害虫声检测技术研究的背景和进展状况,提出了... 详细信息

与传统的储粮害虫检测方法相比较,储粮害虫声检测技术以其简单、快速、价廉、准确等优点正日益受到重视。在综合分析国内外储粮害虫声检测技术研究的文献以及已有工作基础上,扼要评述了储粮害虫声检测技术研究的背景和进展状况,提出了储粮害虫声检测技术研究需要进一步解决的问题和发展趋势。

关键词：储粮害虫检测方法储粮害虫声检测技术

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金属中激光超声信号的频谱分析

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压电与声光 1999年第2期21卷 92-95页

作者：张小凤尚志远陕西师范大学应用声学研究所

利用ＹＡＧ脉冲激光器在金属中诱导光击穿，从而产生超声脉冲。分别用５ＭＨｚ，１．２５ＭＨｚ的压电换能器接收光声信号，然后对其频谱进行分析，证明在光击穿的条件下，光声信号是一个含有多种频率的复频信号，其频谱的主峰出现在０... 详细信息

利用ＹＡＧ脉冲激光器在金属中诱导光击穿，从而产生超声脉冲。分别用５ＭＨｚ，１．２５ＭＨｚ的压电换能器接收光声信号，然后对其频谱进行分析，证明在光击穿的条件下，光声信号是一个含有多种频率的复频信号，其频谱的主峰出现在０～１００ｋＨｚ之间。

关键词：换能器频谱分析金属 YAG脉冲激光器

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CNT array-induced nanobubble assembly,nanodisk fabrication and enhanced spectral detection of CNT bundle density

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Nano Research 2024年第8期17卷 7737-7745页

作者： zhiyuan Xia Ziming Ye Bo Zhao Tingsong Zhang Qi Wang Kun Chen Meng Li Xiaobing Kong Yu-Qing Zheng Enzheng Shi Yuanyuan shang Anyuan Cao School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking UniversityBeijing 100871China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Engineering Westlake UniversityHangzhou 310024China

Alignment,functionalization and detection of carbon nanotube(CNT)bundles are vital processes for utilizing this onedimensional nanomaterial in ***,we report a polymer-assisted wet shearing method to acquire super-aligned craterpatterned CNT arrays by nanobubble(NB)self-assembly with a"migrate and aggregation"mechanism and use craters to controllably mold even-sized nanodisks periodically along CNT bundles with tunable *** green,low-cost method can be extended to diverse substrates and fabricate different *** an example,the Ag-nanodisk-patterned CNT arrays are utilized as substrates of surface-enhanced Raman scattering(SERS)for rhodamine 6G(R6G)and methylene blue(MB)in which a linear correlation is found between the SERS intensity and the CNT bundle density due to the periodic distribution of hot spots,enabling a spectral detection of CNT bundles and their densities by conventional dye *** from routine morphological characterization,this spectral method possesses an enhanced accuracy and a detection range of 0.1–2μm^(–1),showing its uniqueness in the detection of CNT bundle density since the intensity of traditional spectral merely relates to the quantity of CNTs,exhibiting its potential in future CNT-bundle-based electronics.

关键词： CNT arrays nanobubbles self-assembly nanodisks surface-enhanced Raman scattering(SERS)

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超声衰减检测法研究大分子构象变化

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化学学报 2001年第5期59卷 665-669页

作者：王公正房喻胡道道尚志远陕西师范大学化学系陕西师范大学应用声学研究所

以壳聚糖(CS)包埋聚N-异丙基丙烯酰胺(PNIPAM)水凝胶和聚甲基丙烯酸(PMAA)水溶液为模型体系,研究了超声衰减检测法用于探测大分子溶液构象和聚集态变化的可能性.实验表明,超声衰减参量(α)与大分子在溶液或水凝胶中的构象状态密切相关.... 详细信息

以壳聚糖(CS)包埋聚N-异丙基丙烯酰胺(PNIPAM)水凝胶和聚甲基丙烯酸(PMAA)水溶液为模型体系,研究了超声衰减检测法用于探测大分子溶液构象和聚集态变化的可能性.实验表明,超声衰减参量(α)与大分子在溶液或水凝胶中的构象状态密切相关.一般而言,大分子的松散线团构象具有较低的超声衰减能力,而压缩线团构象则具有比较高的超声衰减能力.不过,过度压缩线团构象的超声衰减能力也比较小.据此,可以预期超声衰减检测有可能发展成为一种简单、非破坏性大分子构象研究新方法.

关键词：超声衰减溶液构象聚(N-异丙基丙烯酰胺) 聚甲基丙烯酸水凝胶壳聚糖包埋聚集态

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黄芩含药血清对神经干细胞分化钠离子通道基因及cAMP/PKA信号通路的影响

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中医杂志 2020年第16期61卷 1444-1448页

作者：赵凡尚志远瞿融南京中医药大学江苏省南京市210046

目的研究黄芩含药血清对神经干细胞分化的影响及可能机制。方法分离培养原代乳大鼠神经干细胞,利用免疫荧光法进行鉴定。SD大鼠分别给予500和1000mg/kg黄芩水煎剂每日灌胃1次,连续7天后制备黄芩高、低剂量含药血清。黄芩低、高含药血清... 详细信息

目的研究黄芩含药血清对神经干细胞分化的影响及可能机制。方法分离培养原代乳大鼠神经干细胞,利用免疫荧光法进行鉴定。SD大鼠分别给予500和1000mg/kg黄芩水煎剂每日灌胃1次,连续7天后制备黄芩高、低剂量含药血清。黄芩低、高含药血清均设0.1%、1%、10%三个浓度干预神经干细胞,进行试验药物浓度筛选。收集神经干细胞以每孔1×10^5个接种于24孔板中,实验分为对照组、黄芩含药血清组和含药血清加抑制剂组,每组3个复孔。对照组每孔加入10μl空白大鼠血清,黄芩含药血清组每孔加入10μl筛选浓度的黄芩含药血清,含药血清加抑制剂组每孔加入10μl筛选浓度的黄芩含药血清及1μl浓度为10mmol/L的H89溶液,隔天换液,共分化7天。比较各组细胞中双肾上腺皮质激素(DCX)、神经元核心抗原(NeuN)细胞增长率;检测细胞中钠离子通道亚型SCN1A、SCN2A、SCN3A、SCN8A mRNA表达,蛋白激酶A(PKA)、磷酸化蛋白激酶A(p-PKA)蛋白表达,细胞上清中腺苷酸环化酶(AC)、环磷酸腺苷(cAMP)浓度。结果筛选出1%黄芩高剂量含药血清用于后续实验。与对照组比较,黄芩含药血清组细胞中DCX、NeuN细胞增长率增加,SCN1A、SCN2A、SCN3A、SCN8A mRNA表达增加,p-PKA/PKA值及AC、cAMP浓度增加(P<0.05或P<0.01);与黄芩含药血清组比较,含药血清加抑制剂组上述各指标均不同程度降低(P<0.01)。结论黄芩含药血清可促进海马神经干细胞分化,其机制可能与促进钠离子通道基因、cAMP/PKA通路酶及蛋白的表达有关。

关键词：黄芩神经干细胞细胞分化钠离子通道 cAMP/PKA通路

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双低频超声辐射对碘化钾溶液碘释放量影响的研究

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陕西师大学报（自然科学版） 1999年第1期27卷 51-53页

作者：沈壮志尚志远陕西师范大学应用声学研究所

用碘释放分析了２４ｋＨｚ，３１ｋＨｚ超声的声化学产率随声强的关系，进而研究了由２４ｋＨｚ与３１ｋＨｚ喇叭型及２４ｋＨｚ喇叭型与３１ｋＨｚ阶梯形变幅轩组成的相向辐射系统的声化学产额．结果表明，双频辐射增强的声化学产额与... 详细信息

用碘释放分析了２４ｋＨｚ，３１ｋＨｚ超声的声化学产率随声强的关系，进而研究了由２４ｋＨｚ与３１ｋＨｚ喇叭型及２４ｋＨｚ喇叭型与３１ｋＨｚ阶梯形变幅轩组成的相向辐射系统的声化学产额．结果表明，双频辐射增强的声化学产额与辐射端面积有关，本文对此现象给出理论解释．

关键词：声化学碘释放量碘化钾溶液超声辐射

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