Updated prevalence of latent prostate cancer in Chinese population and comparison of biopsy results: An autopsy-based study

作     者：Yuliang Chen Zhien Zhou Yi Zhou Zhipeng Mai Shijie Jin Zhen Liang Zhiyuan Shang Yuzhi Zuo Yu Xiao Wenze Wang Haibo Wang Weigang Yan 

作者机构：Department of UrologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Gynaecology and ObstetricsBeijing HospitalNational Centre of GerontologyBeijing 100730China Department of PathologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Peking University Clinical Research InstitutePeking University First HospitalBeijing 100034China 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2024年第5卷第1期

页      面：80-87页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 0838[工学-公安技术] 100214[医学-肿瘤学] 100105[医学-法医学] 10[医学] 

基　　金：This work was supported by National High Level Hospital Clinical Research Funding[2022-PUMCH-B-009][2022-PUMCH-A-063].We thank EditSprings(https://www.editsprings.cn)for the expert linguistic services provided.We thank Professor Chao Ma of the Department of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences for his contribution during the construction of Human Tissue and Organ Bank and the collection of autopsy prostate specimens.We would also like to thank every post-mortem donor who makes this study possible 

主　　题：biopsy prevalence latent 

摘      要：Prostate cancer detected by autopsy is named latent prostate *** the repertoire of clinical prostate cancer,latent cancer may better reflect the disease *** clinical prostate specimens,which are obtained exclusively from biopsy-positive cases,prostate specimens obtained through autopsy provide information on biopsy-negative cases,helping calculate the true sensitivity of prostate *** 2014 to 2021,we collected autopsy specimens of the prostate from body donors in China and performed transperineal and transrectal biopsies on specimens before step-sectioning and pathological *** found that the crude prevalence of latent prostate cancer in middle-aged and elderly men was 35.1%(81/231),which was higher than previous estimates for Chinese *** overall per-patient sensitivities of transperineal and transrectal biopsies were not significantly different(33.3%vs.32.1%,p=0.82),but the two approaches differed in preferential sampling area along the proximal-distal axis of the *** biopsy had a higher sensitivity for detecting clinically significant lesions in the distal third(34.7%vs.16.3%,p=0.02)and distal half(30.6%vs.18.1%,p=0.04),while transrectal biopsy had a higher sensitivity for lesions in the proximal half(25.0%vs.13.9%,p=0.046).Both transperineal and transrectal methods of biopsy missed most small lesions(0.5 mL).In conclusion,the prevalence of latent prostate cancer in China has increased over the past 2 *** transperineal and transrectal methods of biopsy had comparable sensitivities but had different preferential sampling *** approaches miss one-third of large lesions.