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电影文化的国际趋同

华夏人文地理 2004年第9期 20-23页

作者：继强 Jonathann Giammarco 彭丽君 robert Spadoni Laurence simmons 香港中文大学现代语言与文化学院美国凯斯西储大学电影系新西兰奥克兰大学传播系

随着《后天》、《蜘蛛侠Ⅱ》在全球热播，我们不得不承认国际电影文化有趋同的势头，是什么造成了这种现象？本期话题就是围绕这个问题展开的。

关键词：电影文化国际市场文化交流审美意识

Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 142-151页

作者： Saleh Elwir robert S.Rahimi Annette C.and Harold C.simmons Transplant Institute Baylor University Medical Center Dallas TX USA

Hepatic encephalopathy is a spectrum of reversible neuropsychiatric abnormalities,seen in patients with liver dysfunction and/or portosystemic *** of the most debilitating complications of cirrhosis,encephalopathy affects 30-45% of *** addition to significantly affecting the lives of patients and their caregivers,it is also associated with increased morbidity and mortality as well as significant utilization of health care *** this paper,we provide an overview on the pathophysiology,diagnosis,management and newer therapies of hepatic encephalopathy.

关键词： Hepatic encephalopathy Cirrhosis Lactulose Rifaximin

Women on the liver transplantation waitlist are at increased risk of hospitalization compared to men

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World Journal of Gastroenterology 2019年第8期25卷 980-988页

作者： Jessica B Rubin Marie Sinclair robert S Rahimi Elliot B Tapper Jennifer C Lai Division of Gastroenterology and Hepatology Department of MedicineUniversity of California-San FranciscoSan FranciscoCA 94143 United States Department of Gastroenterology and Hepatology Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine the University of MelbourneMelbourne 3010VictoriaAustralia Division of Hepatology Annette C.and Harold C.Simmons Transplant InstituteBaylor University Medical CenterDallasTX 75346United States Division of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States

BACKGROUND Hospital admissions are common among patients with cirrhosis,but patient factors associated with hospitalization have not been well *** recent data suggesting increased liver transplant waitlist dropout among women,we hypothesized that women on the liver transplant waitlist would have increased rates of hospitalization compared with *** To evaluate the role of gender on risk of hospitalization for patients on the liver transplant waitlist,in order to help explain gender disparities in waitlist *** Patients listed for liver transplant at a single center in the United States were prospectively enrolled in the Functional Assessment in Liver Transplantation *** included in this retrospective analysis included those enrolled between March 2012 and December 2014 with at least 12 mo of follow up and without hepatocellular *** primary and secondary outcomes were hospitalization and total inpatient days within 12 mo,*** and negative binomial regression associated baseline factors with *** Of the 392 patients,41%were female,with median(interquartile range)age 58 years(52-63)and model for end-stage liver disease 18(15-22).Within 12 mo,186(47%)patients were hospitalized≥1 time;48%were readmitted,with a median of 8(4-15)inpatient *** women than men were hospitalized(54%vs 43%;P=0.03).In univariable analysis,female sex was associated with an increased risk of hospitalization[odds ratios(OR)1.6,95%confidence interval(CI)1.0-2.4;P=0.03],which remained significant on adjusted multivariable analysis(OR 1.6,95%CI:1.1-2.6;P=0.03).Female gender was also associated with an increased number of inpatient days within 12 mo in both univariable and multivariable *** Women with cirrhosis on the liver transplant waitlist have more hospitalizations and inpatient days in one year compared with men,suggesting that the experience of cirrhosis differs between men and women,despite

关键词： Gender Cirrhosis Liver transplantation waitlist Hospitalization Readmission Women

Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles

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Nano Research 2017年第4期10卷 1366-1376页

作者： Chuanqi Peng Xiaofei Gao Jing Xu Bujie Du Xuhui Ning Shaoheng Tang robert M. Bachoo Mengxiao Yu Woo-Ping Ge Jie Zheng Department of Chemistry and Biochemistry The University of Texas at Dallas Richardson TX 75080 USA Children's Research Institute Department of Pediatrics Department of Neuroscience Harold C. Simmons Comprehensive Cancer Center UT Southwestem Medical Center Dallas TX 75390 USA simmons Cancer Center Annette G. Strauss Center for Neuro-Oncology Department of Internal Medicine Department of Neurology and Neurotherapeutics UT Southwestern Medical Center Dallas TX 75390 USA

A major clinical translational challenge in nanomedicine is the potential of toxicity associated with the uptake and long-term retention of non-degradable nanoparticles （NPs） in major organs. The development of inorganic NPs that undergo renal clearance could potentially resolve this significant biosafety concern. However, it remains unclear whether inorganic NPs that can be excreted by the kidneys remain capable of targeting tumors with poor permeability. Glioblastoma multiforme, the most malignant orthotopic brain tumor, presents a unique challenge for NP delivery because of the blood-brain barrier and robust blood-tumor barrier of reactive microglia and macroglia in the tumor microenvironment. Herein, we used an orthotopic murine glioma model to investigate the passive targeting of glutathione-coated gold nanoparticles （AuNPs） of 3 nm in diameter that undergo renal clearance and 18-nm AuNPs that fail to undergo renal clearance. Remarkably, we report that 3-nm AuNPs were able to target intracranial tumor tissues with higher efficiency （2.3× relative to surrounding non-tumor normal brain tissues） and greater specificity （3.0×） than did the larger AuNPs. Pharmacokinetics studies suggested that the higher glioma targeting ability of the 3-nm AuNPs may be attributed to the longer retention time in circulation. The total accumulation of the 3-nm AuNPs in major organs was significantly less （8.4×） than that of the 18-nm AuNPs. Microscopic imaging of blood vessels and renal-clearable AuNPs showed extravasation of NPs from the leaky blood-tumor barrier into the tumor interstitium. Taken together, our results suggest that the 3-nm AuNPs, characterized by enhanced permeability and retention, are able to target brain tumors and undergo renal clearance.

关键词： enhanced permeability and retention brain tumor passive targeting gold nanoparticles renal clearance

DNA origami mediated electrically connected metal–semiconductor junctions

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Nano Research 2020年第5期13卷 1419-1426页

作者： Basu R.Aryal Dulashani R.Ranasinghe Tyler R.Westover Diana G.Calvopia robert C.Davis John N.Harb Adam T.Woolley Department of Chemistry and Biochemistry Brigham Young UniversityProvoUT 84602USA Department of Chemical Engineering Brigham Young UniversityProvoUT 84602USA Department of Physics and Astronomy Brigham Young UniversityProvoUT 84602USA

DNA-based nanofabrication of inorganic nanostructures has potential application in electronics,catalysis,and *** DNA metallization has generated conductive DNA-assembled nanostructures;however,the use of semiconductors and the development of well-connected nanoscale metal-semiconductor junctions on DNA nanostructures are still at an early ***,we report the first fabrication of multiple electrically connected metal-semiconductor junctions on individual DNA origami by location-specific binding of gold and tellurium *** attachment to DNA origami was via DNA hybridization for Au and by electrostatic interaction for *** gold plating was used to create nanoscale metal-semiconductor interfaces by filling the gaps between Au and Te ***-point electrical characterization indicated that the Au-Te-Au junctions were electrically connected,with current-voltage properties consistent with a Schottky ***-based nanofabrication of metal-semiconductor junctions opens up potential opportunities in nanoelectronics,demonstrating the power of this bottom-up approach.

关键词： current-voltage measurement DNA nanofabrication electroless plating gold nanorods nanoelectronics tellurium nanorods

“中心无法保持”:奈保尔处心积虑的伪装(英文)

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英美文学研究论丛 2009年第1期 7-39页

作者： robert D.Hamner English and Humanities Hardin-Simmons University

有一种观点认为,2001年诺贝尔文学奖得主V.S.奈保尔背叛了自己成长于其中的西印度,成了新殖民主义的代言人。可即使苛刻的批评家也承认他在艺术方面的卓越才能,他自始至终都在着力呈现世界上许多地方落后社会的种种弊病。本文通过分析... 详细信息

有一种观点认为,2001年诺贝尔文学奖得主V.S.奈保尔背叛了自己成长于其中的西印度,成了新殖民主义的代言人。可即使苛刻的批评家也承认他在艺术方面的卓越才能,他自始至终都在着力呈现世界上许多地方落后社会的种种弊病。本文通过分析其小说和其他文字,发现在奈保尔令人讨厌的殖民主义表象之下,隐藏着一种深刻的反讽。奈保尔更是将其作家的隐藏身份推向极致;他以一种反讽的方式生活着。他没有为其苛刻进行辩解或规避,而是颠覆性地在他人和作为媒介的自己身上体现出殖民主义最恶劣的一些思想。

关键词：作者人格解构发展中社会存在焦虑隐含反讽叙事理论新殖民主义后殖民批评特立尼达狂欢节